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Systemic Lupus Erythematosus - Springer Nature

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Last Updated: 27 July 2022

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Glucocorticoid discontinuation in pediatric-onset systemic lupus erythematosus: a single-center experience

SLE patients with newly diagnosed pediatric SLE between 2002 and 2021 were excluded from the study, and those who were not followed for less than one year after treatment began and those who were not included in the follow-up were missing. Result Glucocorticoids may have been discontinued in 19 patients after a median observation period of ten months. According to our last follow-up, all patients had poor disease activity with or without glucocorticoids, 19, 8, and 1 patient received mycophenolate mofetil, MMF plus tacrolimus, and MMF plus ciclosporin A. MMF was shown to have significantly reduced flare risk following the introduction of therapy and a shorter time between therapy start and achieving maintenance prednisolone dose of 0. 1 mg/kg/day in a short period. In two patients, foot necrosis was present in two patients. Conclusion Despite the small sample size, these findings support glucorticoid discontinuation as a therapeutic goal in pediatric SLE.

Source link: https://doi.org/10.1007/s00467-021-05350-y


Response to belimumab in thrombotic thrombocytopenic purpura associated with systemic lupus erythematosus: a case-based review

Secondary TTP is often attributed to systemic lupus erythematosus. Patients with idiopathic TTP tTP, especially those with refractory TTP, are insensitive to plasma exchange and high-dose corticosteroids and usually require second-line medications, including newly developed biologics. Belimumab, a B-lymphocyte stimulator-specific inhibitor, was the first approved new therapy for SLE in the last 50 years. Only two cases of SLE-TTP using belimumab have been reported; however, detailed data has not been published. a 28-year-old female patient with palm petechiae, strong tawny urine, yellow stained skin, and sclera; SLE-TTP assisted by high anti-ANA titers; increased lactate dehydrogenase level, increased schistocytes; and a significant deficiency of ADAMTS13 function.

Source link: https://doi.org/10.1007/s10067-022-06155-6


Reproductive concerns and contributing factors in women of childbearing age with systemic lupus erythematosus

Methods One hundred eighty women of childbearing age with SLE were accepted in this cross-sectional research at Affiliated Hospital of Nantong University from March 2021 to December 2021. Results The findings showed that female SLE patients were more concerned about the child's welfare and personal safety than becoming pregnant, fertility risk, partner reveal, and acceptance; SLE patients with the characteristics of living in rural residence, having no reproductive history, fearing unexpected pregnancy, sexual distress, and depression were all worrying fertility issues. Conclusions The study found that female SLE patients should be paid more attention to their fertility problems and that surgical intervention steps can be carried out to reduce their reproductive risks, as well as their long-term quality of life if their disease condition permits.

Source link: https://doi.org/10.1007/s10067-022-06156-5


Orbital myositis in systemic lupus erythematosus: a case-based review

In up to one-third of patients with systemic lupus erythematosus, eye abnormalities account for up to one-third. Orbital myositis, which affects the extraocular muscles and causes pain and restriction with eye mobility, is one of them. In both eyes, we report a case of OM in a 48-year-old female with SLE and secondary Sjogren's Syndrome, who had headache, periorbital edema, and painful ocular signs in both eyes, with no other observable signs. The right medial rectus and left lateral rectus muscles were found thickening in An orbital magnetic resonance image. The patient was treated with prednisone 1 mg/Kg/day with a relief of symptoms. In the majority of these patients, complete relief of symptoms was obtained by steroids therapy. Even when there is no systemic disease activity, the best evidence shows that it is critical to have a high index of suspicion for OM in SLE patients, even though there is no such thing as asymptomatic disease prevalence is present so that appropriate treatment can be initiated early.

Source link: https://doi.org/10.1007/s00296-022-05114-3


Multi-lesion radiomics model for discrimination of relapsing-remitting multiple sclerosis and neuropsychiatric systemic lupus erythematosus

Methods The RNMS or NPSLE patients with a ratio of 3:1 were given to education and test sets. On the higher-weighted court, the mean RIL value of lesions was determined as the mean RIL value of lesions on the higher-weighted court, according to Then. For each subject, single lesions were admitted to one of two disease courts based on their distance to the decision threshold, and a Radiomics Index for Subject was determined. Result In both the preparation and test sets, the discrimination model successfully distinguished RRMS and NPSLE in both testing and test sets, much better than the single-lesion radiomics approach. U2022 Key Points u2022 In RRMS and NPSLE, the radiomic characteristics of brain lesions were different. U2022 The multi-lesion radiomics model developed as a result of a merging strategy was vastly superior to the single-lesion discrimination scheme for discrimination of RRMS and NPSLE.

Source link: https://doi.org/10.1007/s00330-022-08653-2


Converging evidence of impaired brain function in systemic lupus erythematosus: changes in perfusion dynamics and intrinsic functional connectivity

U03a4he's study investigated changes in hemodynamics and functional connectivity in patients with systemic lupus erythematosus with or without neuropsychiatric signs. Participants included 44 patients with neuropsychiatric SLE, 20 SLE patients with no such signs, and 35 healthy controls. Group differences were determined by random samples t-tests, and correlations of rs-fMRI indices with clinical variables and neuropsychological test scores were also estimated, which were also calculated. Result Compared to HC, NPSLE patients, the intrinsic hypoconnectivity of anterior Default Mode Network and hyperconnectivity of posterior DMN components were evident. In the posterior DMN, hemodynamics and connectivity were correlated with lower task results, which led to worse task results. Patients with non-NPSLE hyperconnectivity in posterior DMN and sensorimotor regions coincided by modestly increased hemodynamic lag. Conclusion : Regional brain function adaption to hemodynamic changes in NPSLE may require locally reduced or locally improved intrinsic connectivity.

Source link: https://doi.org/10.1007/s00234-022-02924-x


Clinical features, severity and outcome of acute pancreatitis in systemic lupus erythematosus

Systemic Lupus Erythematosus is a rare yet life-threatening manifestation of Systemic Lupus Erythematosus. The current study aims to investigate the physiologic, danger, death, and consequences of SLE-related AP in India's Indian populations. We retrospectively reviewed medical records of patients with SLE who had AP in the past. For AP, all patients met the SLICC requirements for SLE and ATLANTA criteria. Patients with known risk factors such as gall stone and alcohol were rejected from the study. Sixty-six patients were excluded. The median age of presentation was 24 years, and the majority of patients were diagnosed within the first year of lupus diagnosis. In 39 percent, active nephritis was present, while a quarter had CNS disease. Patients with severe AP had lower C3. Only the presence of shock remained as an independent predictor of death in the multivariate analysis. Pancreatitis, an early onset of SLE, is a sign of active disease, and it is often associated with active disease.

Source link: https://doi.org/10.1007/s00296-021-04834-2


Evaluation of the European League Against Rheumatism/American College of Rheumatology-2019 classification criteria in patients with childhood-onset systemic lupus erythematosus: a single-center retrospective study

This research sought to compare the effectiveness and specificity of the European League Against Rheumatism/American College of Rheumatism-2019 classification criteria with previous classification schemes for patients with pediatric-onset systemic lupus erythematosus. U2265 1:80 is the same as controls for this single-center retrospective review of 53 patients with cSLE and 53 patients with antinuclear antibody titers. ANA titers u2265 1:80 for all patients with cSLE had ANA titers u2265 1:80. The EULAR/ACR-2019 csLE screening tool used earlier this year may have greater sensitivity but low specificity, but it could have higher precision and be more appropriate for determining SLE in a pediatric population. u2022 The EULAR/ACR-2019 guidelines more consistently mischaracterized non-SLE patients who did not have SLE, particularly those with MCTD or ps, as having SLE than the previous definition in patients with childhood onset.

Source link: https://doi.org/10.1007/s10067-022-06138-7


Nailfold capillaroscopy changes associated with anti-RNP antibodies in systemic lupus erythematosus

The anti-U1RNP antibody is correlated with specific organ involvement in patients with systemic lupus erythematosus. In comparison to RNP-negative SLE patients and mixed connective tissue disease patients, the aim of this research is to determine the relationship of anti-U1RNP antibody with microvascular changes by NFC in RNP-positive SLE patients and mixed connective tissue disease patients. In consecutive patients with SLE with or without anti-U1RNP positivity, a multi-U1RNP blood test was performed. Compared to RNP-negative SLE patients, RNP-positive SLE patients had more frequent giant capillaries, enlarged capillaries, and ramified capillaries. Patients with MCTD had a reduced capillary density in comparison to patients with RNP-positive SLE and RNP-negative SLE. In patients with RNP-negative SLE, interstitial lung disease, and disease duration, the reduction in capillary density was less prominent in patients with RNP-negative SLE as compared to RNP-positive SLE, which was not influenced by Raynaud u2019s condition, interstitial lung disease, and disease duration.

Source link: https://doi.org/10.1007/s00296-021-04894-4


Catatonia in systemic lupus erythematosus: case based review

Catatonia is a rare psychomotor disorder characterized by stupor, posturing, and echophenomena. Here we present two cases of systemic lupus erythematosus with catatonia, who improved with immunosuppressive therapy, and examine the cases reported in the literature. The second case was presented with acute cutaneous lupus erythematosus, fever, polyarthropathies, polyarthralgias, nephritis, cytopenias, and catatonia along with catatonia.

Source link: https://doi.org/10.1007/s00296-021-05006-y

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions