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Systemic Lupus Erythematosus - Europe PMC

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Last Updated: 27 July 2022

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Neuropsychiatric manifestations in childhood-onset systemic lupus erythematosus.

In the first two years of disease, the majority of patients with childhood-onset SLE have neuropsychiatric disorders. Patients with more than one neuropsychiatric event during their disease course receive more than one neuropsychiatric event per week, with an average of 2-3 events per person. In childhood-onset SLE, the aim of this Research is to identify the genetic, atomic, and neuroimaging characteristics, as well as current treatment options.

Source link: https://europepmc.org/article/MED/35841921


Interferon alpha and non-specific markers of inflammation in patients with systemic lupus erythematosus.

Aim To determine the value of IFN-u03b1 in patients with systemic lupus erythematosus and to compare IFN-u03b1 to measures of non-specific biochemical parameters of inflammation. Methods Research included 55 patients with SLE diagnosis, as well as a control group of 25 healthy participants. Only serum globulin was significantly higher in IFN-u03b1 positives in comparison to IFN-u03b1 negative SLE patients. Conclusion In younger patients, increased IFN-u03b1 values were found, and the relationship between IFN and globulin was established.

Source link: https://europepmc.org/article/MED/35633125


HERC6 is upregulated in peripheral blood mononuclear cells of patients with systemic lupus erythematosus and promotes the disease progression.

Peripheral blood mononuclear cells are any peripheral blood cell with round nuclei, including lymphocytes and monocytes, whose physicochemical characteristics are randomized by simple immune changes, making them a potentially useful source of SLE blood test results and therapeutic targets. This research was designed to investigate the upregulation of PBMCs in patients with SLE and their biological function. In four Gene Expression Omnibus gene sets, three gene expression variations were significantly different, including E6-AP carboxyl terminus and regulator of chromosome condensation 1 -like domains containing E3 ubiquitin protein ligase family member 6 expressions. In addition, HERC6 expression in SLE patients' PBMCs was upregulated relative to that obtained from normal donors in PBMCs. HERC6 was strongly associated with SLE clinical phenotypes, including complement C3 intake, erythrocyte sedimentation rate, and SLE disease activity index. In conclusion, the amount of HERC6 in PBMCs of patients with SLE was increased.

Source link: https://europepmc.org/article/MED/35880641


Characteristics and risk factors of severe coronary artery disease in systemic lupus erythematosus: A multicenter, Chinese Rheumatism Date Center database study.

Aim Systemic lupus erythematosus in severe coronary artery disease is correlated with increased mortality. Methods This multicenter, cross-sectional research enrolls consecutive patients with SLE in the Chinese Rheumatism Date Center registry. Patients with severe CAD, including angiography-confirmed stenosis u226550% in the left main, u226570% in other key coronary arteries, or myocardial infarction were categorized into the CAD group. Forty-three patients with SLE had severe CAD, 30 of whom were female; 35 of whom were older; 32 belonged to the older age group; and 8 were in the younger age group. Male risk factors were age and 5 key CAD risk factors, SLEDAI-2K, and positive APL, although female risk factors were age and 5 key CAD risk factors, including positive APL. Conclusions We recommend testing for severe CAD in patients with SLE with age- and gender-stratified risk factors.

Source link: https://europepmc.org/article/MED/35880514


Development of a claims-based flare algorithm for systemic lupus erythematosus.

Objectivise Objective Objective: Using a linked claims-electronic medical record database, we were able to design a systemic lupus erythematosus flares. Methods This report was a retrospective review of linked administrative and EMR data from 1 January 2003 to 31 March 2019. Adult SLE patients with at least 12 months of continuous enrollment in claims data, 12 months of clinical involvement in EMR, and an absence of malignancies excluding basal and squamous cell carcinoma were among the deficiencies. A series of potential flare predictor variables identified in claims were based on a set of established variables from a previous algorithm, with the addition of other SLE-related metrics based on clinical input. Conclusions and Conclusions The final algorithm shows promise in identifying probable flares in administrative claims data in a more effective and more streamlined manner that can aid in the analysis of SLE within the context of flares.

Source link: https://europepmc.org/article/MED/35866412


Abnormal lower expression of GPR183 in peripheral blood T and B cell subsets of systemic lupus erythematosus patients.

In T cell-dependent antibody responses, a G protein-coupled receptor 183 has been shown to mediate immune cell migration and localization of immune cells. To date, there has been no systematic review of GPR183 in lymphocyte subsets of SLE patients. Patient with SLE's GPR183 expression levels in above peripheral blood lymphocyte subsets were reduced overall, compared to healthy controls. The inactive and active SLE patients' GPR183 expression shows that the GPR183 response may be concerned with SLE's disease activity. An integrated CPR183 expression in circulating CD27 - IgD + B cells may be helpful in distinguishing between inactive and active SLE patients, according to a further receiver operating characteristic curve analysis. In addition, type I interferon stimulation could down-regulate the expression of GPR183 in peripheral blood T and B cell subsets.

Source link: https://europepmc.org/article/MED/35875859


Evaluating the Use of Glucocorticoids Among Belimumab-Treated Patients With Systemic Lupus Erythematosus in Real-World Settings Using the Rheumatology Informatics System for Effectiveness Registry.

Belimumab's clinical manifestations of SLE and reduced glucocorticoid doses in clinical trials and clinical use; however, associations have not been reviewed using multi-institutional electronic health record data; however, studies have not been conducted using multi-institutional electronic health record data. Patients' mean daily oral glucocorticoid dose was determined by the index's 6 months preindex against the six months post index, according to the primary study. According to the prescribing information for the first 8 weeks post index, 767 patients receiving their first belimoid prescription had available glucorticoid prescribing data, while 204 had glucocorticoids prescribed in the 6 months preindex and received belimumab. Preindex: 12. 5 mg/day, 3 months post index, down to 10. 3 mg/day over the 6 months post index, and 8. 7 and 9. 0 mg/day at 12 and 24 months post index. After belimumab's use, the study revealed declines in mean daily glucocorticoid dose.

Source link: https://europepmc.org/article/MED/35872599


Enrichment of Complement, Immunoglobulins, and Autoantibody Targets in the Proteome of Platelets from Patients with Systemic Lupus Erythematosus.

Systemic lupus erythematosus is a complex disease characterized by autoimmunity toward apoptotic cells, elevated amounts of circulating immune complexes, and complement activation. Methods Platelets were isolated from 23 patients with SLE from 23 patients with SLE. For further investigation, five individuals with the highest and lowest average platelet forward scatter were chosen. Platelet protein synthesis was determined by liquid chromatography with tandem mass spectrometry and compared to platelets from five healthy controls. Platelets from SLE patients with increased degranulation and skewed hemostatic balance. Immunoglobulin proteins were positively correlated to serum complement C3 and C4 in platelets of normal size in the SLE proteome, and the highest relative amounts were found in platelets of normal size. Platelets from SLE patients' compiled protein profile, including immunoglobulins, complement proteins, and autoantigens, largely independent of the platelet size and in agreement with an integrated role for platelets in SLE.

Source link: https://europepmc.org/article/MED/35419777


Clusters of clinical and immunologic features in patients with bullous systemic lupus erythematosus: experience from a single-center cohort study in China.

Background Bullying bronchi erythematosus is a rare subtype of systemic lupus erythematosus that is clinically defined by subepidermal tense vesicles or bullae. Methods We retrospectively reviewed all patients who met the diagnostic criteria for BSLE in our institution from 2015 to 2021. SLE is a disorder of the central nervous system. 12 patients with SLE were diagnosed with BSLE, while 12 others developed BSLE. The first sign in five of the BSLE patients was white, and they appeared after SLE surgery in the remaining seven patients, with a median duration of 36 months. Patients with elevated disease prevalence were found in five out of 10/12 patients, which indicated high disease risk. Patients in the BSLE group had significantly higher incidences of proteinuria, hematuria, hemolytic anemia, and leukopenia than those in the control group. Conclusions: Vesiculobullous lesions may be the first sign and indicate a high incidence of disease in patients with BSLE.

Source link: https://europepmc.org/article/MED/35871005


The predictive value of fibrinogen-to-albumin ratio in the active, severe active, and poor prognosis of systemic lupus erythematosus: A single-center retrospective study.

Objective Objectives Aim: To determine the prediction and effect of fibrinogen-to-albumin ratio on active, remarkably infectious, and poor prognosis of systemic lupus erythematosus. Methods One hundred and sixty-eight patients with SLE who were treated in our hospital were registered, according to the clinical, laboratory results, and disease prognosis of all patients were collected and analyzed, as well as disease prevention. SLEDAI was positively correlated with SledAI, while ALB was negatively related to SLEDAI, and the related coefficients were 0. 304, 0. 268, 0. 270, respectively. FAR's predictions for active, severe active, and poor prognosis SLE were 0. 769, 0. 769, and 0. 734, respectively, which were much higher than FIB and ALB. Conclusion Fibrinogen-to-albumin ratio, a determining factor of healthy, highly mobile, and poor prognosis SLE's low predictive value was higher predictive value than FIB and ALB for the duration and prognosis of SLE.

Source link: https://europepmc.org/article/MED/35870195

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions