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Systemic Lupus Erythematosus - Crossref

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Last Updated: 27 July 2022

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Short Bowel Syndrome Following Resection of Gangrenous Bowel due to Superior Mesenteric Artery Thrombosis in a Patient with Systemic Lupus Erythematosus: Lessons Learnt in a Resource-Poor Setting

Abstract of Short Bowel Syndrome is an intestinal blockage resulting from an inadequate length of the intestine following intestinal transplantation, which can be related to other conditions such as vascular disease, neoplasma, or inflammatory bowel disease. Following intestinal resection in a patient with systemic lupus erythematosus is a therapeutic challenge, given that immunosuppressive therapy, wound healing, nutritional optimization, and other potential risks are factored in. Case Presentation A 23-year-old male diagnosed with SLE for acute diffuse abdominal pain for a sixteen-hour period related to vomiting that was tachycardic on admission, and the pulse rate was poor. The patient was left side acute lower limb ischemia after about one week of in-hospital stay. In all three compartments of the left lower limb's CT-angiogram, the left common artery embolus and the left lower limb muscles were not viable. The patient is still inpatient for three months with PPN and supportive care, and after discharge, the patient is expected to be inserted a peripherally inserted central catheter for continuous PPN after discharge. Conclusion SLE can be a cause of SBS secondary to bowel gangrene resulting in thromboembolism, and in the case of SLE patients undergoing intestinal resection causing SBS, it is a challenging yet manageable problem in terms of medical care, where all the problems should be identified early and treated until the patient achieves a healthy gut adaptability.

Source link: https://doi.org/10.21203/rs.3.rs-1839744/v1


A Current Review of Systemic Lupus Erythematosus Treatment Using Monoclonal Antibodies

Lupus is a heterogeneous and inflammatory autoimmune disease that affects the body's immune system. Systemic lupus erythematosus : The most common form of lupus is systemic lupus. SLE is an autoimmune disease in which the immune system attacks the body's tissues, resulting in widespread inflammation and tissue damage in the organs concerned. It seems that it is a form of B-cell disease in which autoantibodies attack the cells. Systemic lupus erythematosus autoimmune diseases with diverse treatment approaches. In addition, safety and effective doses, we will also address post-marketing use and ongoing clinical trials, as well as safety and effective doses.

Source link: https://doi.org/10.2174/2211550111666220329183309


Detection of neutrophil extracellular traps in patient plasma: method development and validation in systemic lupus erythematosus and healthy donors that carry IRF5 genetic risk

Neutrophil extracellular traps are web-like structures that neutrophils have extruded after activation or in response to microorganisms. More recently, elevated NETs have been associated with COVID-19 disease severity. Multiplex ELISA and immunofluorescence techniques were used here to develop new methods for the quantification of NETs in patient plasma. In this research, blood from patients with SLE, non-genotyped healthy controls, and genotyped healthy controls that carry either the homozygous risk or non-risk IRF5-SLE haplotype were used. Multiplex ELISA testing using antibodies that detect myeloperoxidase, citrullinated histone H3 and DNA also allowed reliable detection of NETs in plasma samples from SLE patients and healthy donors with IRF5 genetic risk. For small amounts of patient plasma, the immunofluorescence smear assay is a relatively simple, cheap, and quantifiable method of determining NET detection.

Source link: https://doi.org/10.3389/fimmu.2022.951254


GADD45a and GADD45b Genes in Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients

Background: GADD45 genes are stress regulators in response to cellular stress response, and they have been activated signal pathways leading to the production of inflammatory cytokines. This article is intended to investigate the links between GADD45a and GADD45b genes with rheumatoid arthritis and systemic lupus erythematosus patients. Result: The GADD45b gene was significantly lower in RA patients than in control cases, despite control conditions. In DR4-negative RA patients with a haze ratio of -712 CT, the odds ratio of GADD46b genotype -712CT was 0. 41. In SLE patients with GADD45b -712CT genotype with anti-RNP antibodies, the odds ratio was 4. 14 in clinical manifestation.

Source link: https://doi.org/10.3390/jcm8060801


Persistence of Depression and Anxiety despite Short-Term Disease Activity Improvement in Patients with Systemic Lupus Erythematosus: A Single-Centre, Prospective Study

A prospective observational survey was carried out on 40 adult SLE outpatients with active disease who received standard-of-care to investigate longitudinal trends in anxiety, depression, and lupus activity. The Hospital Anxiety and Depression Scale determined anxiety and depression at baseline and six months. These findings reveal a high prevalence of active SLE in active SLE that persists despite disease surveillance, and emphasize the importance of considering socioeconomic factors as part of comprehensive patient evaluation.

Source link: https://doi.org/10.3390/jcm11154316


Incidence of Rodgers-negative individuals in systemic lupus erythematosus patients

According to a retrospective analysis of patients who died anti-Rg, one third suffered with SLE-related diseases, but none had SLE as a primary cause.

Source link: https://doi.org/10.21307/immunohematology-2019-1051


Mitochondrial impairment and repair in the pathogenesis of systemic lupus erythematosus

Nucleic acid autoantibodies, rise type I interferon levels, and immune cell hyperactivation are all typical features of systemic lupus erythematosus. Notably, immune cell activation necessitates a high level of cellular energy that is predominately generated by the mitochondria. Clinical trials on mitochondrial redox imbalance among mROS scavengers and those investigating defective mitophagy have provided new insight into SLE prophylaxis and therapy. However, the precise mechanism underpinning the cell fate at the molecular level is uncertain. This report explores specific mitochondrial functions and pathways that are involved in immune responses and pathways that are related to immune responses, as well as how mitochondrial dysfunction contributes to SLE pathogenesis. In addition, we discuss the possibility of new mitochondria-targeting drugs for SLE therapy. A promising start in the search for effective treatments for systemic autoimmune diseases, particularly SLE.

Source link: https://doi.org/10.3389/fimmu.2022.929520


LESIONS OF THE GASTROINTESTINAL TRACT AND HEPATOBILIARY SYSTEM IN SYSTEMIC LUPUS ERYTHEMATOSUS WITH JUVENILE ONSET

Systemic lupus erythematosus is a chronic autoimmune disease with a variety of medical signs that can affect the gastrointestinal tract. In some situations, the GIT and the hepatobiliary system's involvement in SLE with juvenile onset is considered unfavorable prognosis factor with a high risk of persistent organ dysfunction formation, which is life-threatening.

Source link: https://doi.org/10.24110/0031-403x-2022-101-4-122-132


Association of Clinical Manifestations of Systemic Lupus Erythematosus and Complementary Therapy Use in Taiwanese Female Patients: A Cross-Sectional Study

Systemic lupus erythematosus is a chronic systemic autoimmune disease that affects predominantly women in the early years of childbearing years. However, to our knowledge, no studies have investigated the relationship between clinical signs of SLE and complementary therapies. According, this research sought to determine the correlation of complementary therapies with common medical signs in Taiwanese female patients with SLE. SLE's 40 percent of the 317 female patients with SLE had 60 percent were 40 years or older. Renal participation was strongly linked to the use of probiotics and a visit to a hospital's Chinese medicine department. Conclusions: We found that various clinical signs of SLE were related to the use of various complementary therapies. Patients with SLE should have up-to-date knowledge of common complementary therapies and be able to provide evidence-based assistance to patients with SLE.

Source link: https://doi.org/10.3390/medicina58070944


Clusters of clinical and immunologic features in patients with bullous systemic lupus erythematosus: experience from a single-center cohort study in China

Background and Background Bullying Systemic lupus erythematosus is a rare subtype of systemic lupus erythematosus that is clinically characterized by subepidermal tense vesicles or bullae. Methods We retrospectively reviewed all patients who met the diagnostic criteria for BSLE in our institution from 2015 to 2021. SLE is a disorder of the central nervous system, 12 of whom have BSLE, out of 4221 people with SLE, 12 have developed BSLE. The first sign in five of the BSLE patients, as well as SLE-related illness in the remaining seven patients, were clear, with a median duration ranging from SLE onset of 36 months. Patients with high disease risk were seen in the SLE disease activity index, which indicated increased disease activity. Patients in the BSLE group had significantly higher incidences of proteinuria, hematuria, hemolytic anemia, and leukopenia than those in the control group. Conclusions Vesiculobullous lesions may be the first signs of a high incidence of BSLE patients with a high incidence of streulitis.

Source link: https://doi.org/10.1186/s13023-022-02445-z

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions