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Systemic Lupus Erythematosus - Astrophysics Data System

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Last Updated: 27 April 2022

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Induction of PP2A Bβ, a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus

The B subunit's expression in primary human T cells was sufficient to cause apoptosis, but silencing with siRNA protected activated T cells from IL-2-induced cell death. We investigated the governing of PP2A B in this autoimmune disease because T-cell apoptosis is known to have been altered in T cells from patients with systemic lupus erythematosus. In half of the patients, we found that PP2A B did not rise on IL-2 deprivation. Importantly, kinetics of cell death in cells of patients that up-regulated PP2A B in a normal manner were found. The phosphatase PP2A, particularly the holoenzyme produced by PP2A B, has been identified by us. In a subset of SLE patients, we suggest that defective production of PP2A B resulting in apoptosis resistance and longer life of autoreactive T cells.

Source link: https://ui.adsabs.harvard.edu/abs/2011PNAS..10812443C/abstract


Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice

Systemic lupus erythematosus is an autoimmune disease that is six to eight times more common in women of African descent than in women of European descent. Here we have evidence that a genetic susceptibility to SLE protects against cerebral malaria. These findings show that the high prevalence of SLE among women of African descent living outside of Africa may have evolved from genes that are vital in cerebral malaria's immune control, but that without malaria, autoimmune disease can result.

Source link: https://ui.adsabs.harvard.edu/abs/2011PNAS..108.1122W/abstract


Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

We wanted to determine TLR7 in human SLE after previous research that duplicated Toll-like receptor 7 promotes lupus-like disease in male BXSB mice. G-allele carriers had increased TLR7 transcripts and more pronounced IFN signature than C-allele carriers, with more pronounced IFN signature than C-allele carriers; heterozygotes had 2. 7-fold higher transcripts of G-allele than C-allele; C-allele had improved TLR7 transcripts and more pronounced IFN signature than C-allele carriers; and C-allele carriers had more pronounced IFN signature than C-allele carriers had higher transcripts of G-allele carriers had increased TLR7 transcripts and & C-allele & C-Long transcripts and greater transcripts and TLR7 transcripts; and compared to G-fold higher transcripts of G-allele than C-allele than C-allele than C-allele than C-allele than C-allele than C-allele than C-allele; These results showed a functional polymorphism in type I IFN pathway gene TLR7, which is especially relevant in Chinese and Japanese male subjects.

Source link: https://ui.adsabs.harvard.edu/abs/2010PNAS..10715838S/abstract


Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription

Inadequate quantities of the essential cytokine IL-2 are present in patient with systemic lupus erythematosus. SLE T cells show reduced T-cell receptor-CD3 chains, and forced expression of CD3 in SLE T cells helps restores IL-2 production. We previously reported that SLE T cells exhibit reduced amounts of the T-cell receptor-CD3 chain, and forced expression of CD3 in SLE T cells has restoreds IL-2 production. Our results reveal that SF2/ASF controls IL-2 production and that reduced SF2/ASF expression in SLE T cells contributes to poor IL-2 production.

Source link: https://ui.adsabs.harvard.edu/abs/2013PNAS..110.1845M/abstract


Gut Microbiota in Human Systemic Lupus Erythematosus and a Mouse Model of Lupus

Here we explore the evolution of the gut microbiota in a murine lupus model, NZB/W F1, as well as intestinal dysbiosis in a small group of SLE patients with active disease. The gut microbiota changed dramatically before and after the outbreak of lupus disease in NZB/W F1 mice, with greater variety and increased representation of several bacterial species as lupus progressed from the pre-disease stage to the diseased stage. In addition to treating SLE-like signs with dexamethasone, we found that a larger number of lactobacilli in the gut microbiota could be connected to more severe disease in NZB/W F1 mice using dexamethasone. SLE patients with active lupus disease had an altered gut microbiota that differed in several specific bacterial species and was less varied, with increased amounts of Gram-negative bacteria in comparison to control subjects with immune-mediated diseases.

Source link: https://ui.adsabs.harvard.edu/abs/2018ApEnM..84E2288L/abstract


A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus

Systemic lupus erythematosus is a multisystem autoimmune disease more common among African and Asian people than Caucasian origins. Both Caucasians and Southeast Asians have shown that a SNP in human FCGR2B that abrogates receptor function is strongly linked to SLE susceptibility. We show that homozygosity for the minor allele is strongly linked to significant malaria in an East African population.

Source link: https://ui.adsabs.harvard.edu/abs/2010PNAS..107.7881W/abstract


High titers of antinuclear antibody and the presence of multiple autoantibodies are highly suggestive of systemic lupus erythematosus

The aim of this research is to investigate the correlation between antinuclear antibody titer and specificity, as well as the relationship between the number of positive-autoantibodies in antinuclear antibodies and specificity for systemic lupus erythematosus, as well as the identification of SLE diagnoses. In this analysis, 148 patients with SLE patients were enrolled, total of 1297 patients with ANA results. According to an elevated titer-specific likelihood ratio, the specificity of ANA titer 1 +, 2 +, and 3 + for SLE was estimated to be 81. 29%, 90. 69%, and 96. 22% respectively, with a higher titer-specific likelihood ratio. SLE and SLE's high titers of ANA and the presence of multiple AAbs in ANAs are highly specific for SLE and highly suggestive of SLE.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..12.1687L/abstract


Associations of lymphocyte subpopulations with clinical phenotypes and long-term outcomes in juvenile-onset systemic lupus erythematosus

Methods A cohort of 60 JSLE patients obtained blood samples during acute disease, of whom 34 patients obtained additional samples during inactive disease. Conclusions The number of CD4+ T, and NK cells in JSLE patients were markedly reduced in comparison to HC, while CD8+ T, NKT, and CD19+ B cells' percentages were significantly elevated. In JSLE patients with lupus nephritis than in non-LN JSLE patients and HC, the percentage of regulatory T cells was considerably lower than in non-LN JSLE patients and HC. Mucosal ulcers were remarkably related to the T cells high group and NK cells high group. The CD4+ T cell high group was positively associated with arthritis, and the NKT cells high group was strongly associated with autoimmune hemolytic anemia. At 6 months of follow-up, the percentage of Tregs was significantly raised, and LN JSLE's Treg percentage was lower than the non-LN JSLE group.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1763536L/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions