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Syphilis - Zenodo

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Last Updated: 21 June 2022

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Nonspecific protective factors in patients with early latent syphilis (report 1).

The findings of the study are based on the findings of a comprehensive investigation conducted before the treatment of 142 patients with early latent syphilis and 20 others of the comparison group. In patients with more than a year of infection, the amount of IL-10 and IL-6 was also elevated. In patients with an infection of more than a year, the most significant abnormalities of neutrophil metabolism were discovered; a difference in the circulating immune complexes concentration was also present. The content of pro-inflammatory and anti-inflammatory cytokines in patients with early latent syphilis was significantly elevated and largely dependent on the time of infection. Despite a steady decrease in the number of CD16+ lymphocytes in patients with early latent syphilis, there is also a discrepation between CD25+ and late activation factor HLA-DR.

Source link: https://zenodo.org/record/6597089


Failure to recognize Low non-treponemal titer syphilis infections in pregnancy May lead to widespread under-treatment

In Brazil, maternal syphilis has grown by fivefold in the last decade. We hypothesized that low non-treponemal titers may result in reduced penicillin therapy in Brazil, although penicillin is the only appropriate treatment for maternal syphilis. Methods: We used Brazilian Ministry of Health statistics on women diagnosed with maternal syphilis between January 1, 2010 and December 31, 2018, in order to determine predictive factors of penicillin therapy, we used a random-effects logistic regression model with a cluster correction at the state level to determine predictors of penicillin treatment. Women in this cohort who did not receive penicillin were in prenatal care, according to 83·e; 82 percent of women in this cohort were pregnant with inadequate prenatal care and inadequate care for syphilis. Although the source of the maternal syphilis epidemic in Brazil is multifactorial, we believe our findings can be used to create targeted interventions across Brazil and influence global public health policies.

Source link: https://zenodo.org/record/6591411

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions