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Syphilis - PubMed

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Last Updated: 21 June 2022

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Ocular Syphilis Mimicking Giant Cell Arteritis.

Syphilis, a rare cause of vision loss, is most common after an infection of the meninges, brain tissue, and parenchyma. Syphilis can be similar to auto-immune disease like giant cell arteritis, which may also cause sudden vision loss. Spirochete Treponema pallidum can be transmitted sexually and cause painless ulcers. In secondary and tertiary stages, ocular syphilis can affect both parts of the eye. Physicians should keep in mind the possibility of ocular syphilis in patients who present with a sudden loss of sight and severe headaches.

Source link: https://doi.org/10.7759/cureus.24715


Standardised protocol for a prospective cross-sectional multicentre clinical utility evaluation of two dual point-of-care tests in non-clinical settings for the screening of HIV and syphilis in men who have sex with men.

The evaluation of the utility of these two tests in CBVCT services is a high priority as a community-based voluntary, consulting, and testing service are all affordable HIV and syphilis testing and counseling services that have a high acceptability among males who have sex among men.

Source link: https://doi.org/10.1136/bmjopen-2021-055275


A peculiar case of syphilis infection: The great imitator is on the rise.

a case report of syphilitic uveitis and papillitis with acute vision loss is presented here, as a rare case of a tertiary syphilis infection epidemic mimicking a massive cell arteritis or arteritic anterior ischemic optic neuropathy. We hope to raise the risk of syphilis infections on the rise, as well as the importance of syphilis testing in patients with otherwise unexplained uveitis.

Source link: https://doi.org/10.1016/j.idcr.2022.e01521


Laboratory Evaluation of the DPP Syphilis Screen & Confirm Assay.

Since syphilis is a public health issue, new strategies and methods for detecting active syphilis cases should be tested for future use. In 383 fully characterized stored serum samples, we reviewed the laboratory results of the DPP Syphilis Screen & Confirm rapid immunodiagnostic test, which uses visual inspection and the manufacturer's electronic test microreader, for the detection of treponemal and nontreponemal antibodies. respectively, we used the Treponema pallidum particle agglutination test and rapid plasma reagin test as benchmarks for the DPP Syphilis Screen & Confirm assay treponemal and nontreponemal components. Using serum, the DPP Syphilis Screen & Confirmation assay showed good results, compared to reference syphilis tests, using serum. Importance Syphilis remains a public health issue; therefore, health services must include screening techniques that enable a fast and accurate diagnosis to ensure appropriate treatment. Although DPP Syphilis Screen & Confirm Assay simultaneously detects treponemal and nontreponemal antibodies, it's also a good start for identifying patients in situations where there is no infrastructure to perform routine syphilis testing, but it is still necessary to have evidence demonstrating the effectiveness of this technology in various scenarios. We found that the test does well, in comparison to TPPA and RPR procedures, using frozen samples from participants at a high risk of acquiring syphilis. The DPP Syphilis Screen & Confirm Assay microreader, as well as monitoring treatment responses in the field, may assist in the detection of active syphilis cases and perhaps monitoring treatment responses.

Source link: https://doi.org/10.1128/spectrum.02642-21


Geospatial Social Determinants of Health Correlate with Disparities in Syphilis and Congenital Syphilis Cases in California.

Syphilis and congenital syphilis are on the rise in California. We speculated that geospatial socioeconomic determinants of health play a role in such health inequities. The HPI is a composite index that assigns a score to every California census tract based on eight socioeconomic indicators associated with health. We divided CA census tracts into four quartiles based on HPI results, and then used 2013-2020 CA sexually transmitted diseases surveillance results to compare overall syphilis and CS case numbers, incidence rates, and incidence rate ratios among these quartiles. The IRRs in the lowest quartile were 17 for CS, 4. 5 for late/unknown duration syphilis, 2. 6 for P&S syphilis, and 2. 3 for early NPNS syphilis, according to a reference. We also found a direct correlation between less healthy environments and syphilis/CS in California, supporting our assertion that SDH correlates with disparities in syphilis, particularly CS.

Source link: https://doi.org/10.3390/pathogens11050547


A cross-sectional survey on attitudes of men who have sex with men towards anal self-examination for detection of anal syphilis.

According to statistics, men who have sex with men who are practising receptive anal sex are more likely to develop secondary syphilis, implying that primary anorectal lesions are unlikely to be missed. 68% of those who had never experienced ASE, 68% would consider doing ASE in the future with a predicted median rate of 2 times per 4 weeks, while men who were already doing ASE were doing it at median 1 per 4 weeks.

Source link: https://doi.org/10.1038/s41598-022-12881-3


Health Information and Monitoring of Sexually Transmitted Infections (SIM study): a single-center, parallel, three-arm randomized controlled trial protocol for enhancing adherence to syphilis treatment and follow-up.

Syphilis has recently resurfaced as a significant public health issue. Independent syphilis outbreaks have risen in North America, Europe, and Australia since the 2000s; in Brazil, there have been steady rises in both congenital and acquired syphilis. The aim of this clinical trial was to identify treatment and monitoring methods in patients with syphilis, including a follow-up by phone and at public health centers.

Source link: https://doi.org/10.1186/s13063-022-06383-w

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions