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Syphilis - Europe PMC

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Last Updated: 21 June 2022

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Predicting adverse pregnancy outcomes of pregnant mothers with syphilis based on a logistic regression model: a retrospective study

The aim: To determine whether a simple predictive model can be developed of risk factors leading to adverse pregnancy outcomes in infants of syphilitic mothers during pregnancy that can predict newborn APOs. We tested the predictors, created a prediction model, and evaluated the prediction results in the test set, among other things in the preparation process. Results:: In comparison to the APOs group, pregnant women in the non-APOs group were enrolled in a longer treatment course. : Our report, based on a prediction model of APOs in Suzhou, investigated the effect of several aspects of syphilis pregnant women's pregnancy outcomes.

Source link: https://europepmc.org/article/PPR/PPR507539


Secondary syphilis of the oropharynx and cervical lymph nodes: a case report.

Secondary syphilis is extremely restricted to the head and neck, including the oropharynx and cervical lymph nodes. Often this series of signs can be mistaken for head and neck cancer. In a transgender woman in her forties who was previously suspected of oropharyngeal squamous cell carcinoma, we present a case of an enlarging throat and painless cystic neck mass.

Source link: https://europepmc.org/article/MED/35710349


Estimation of the Lifetime Quality-Adjusted Life Years (QALYs) Lost Due to Syphilis acquired in the United States in 2018.

In 2018, the aim of this survey was to determine the health risks of syphilis in the United States in terms of the number of quality-adjusted life years attributable to infections. The average lifetime number of QALYs lost per infection was determined by We, and the total number of QALYs lost due to syphilis, which was introduced in 2018. [0. 03-0. 19 95% uncertainty interval] ] Our estimates The average number of discounted lifetime QALYs lost per infection as 0. 09 [0. 05-0. 3. 19 95% uncertainty interval] We estimated that the average number of discounted lifetime QALYs lost per infection as 0. 09 [0. 03-0. 19 95% uncertainty interval ] equates to 0. 09 [0. 03-0. 19 95% uncertainty interval ]. The estimated number of QALYs lost as a result of syphilis treatment in 2018 was 13,349[5,071-31,360]. Although MSM's per-case loss was the lowest among MSM, MSM's overall burden accounted for 47 percent of the overall burden. Conclusions Syphilis is a major health problem both adults and children. Quantifying these health risks in terms of QALYs can help cost-effectiveness studies be more accurate, as well as facilitating comparisons of the burden of syphilis to that of other disorders.

Source link: https://europepmc.org/article/MED/35684943


Standardised protocol for a prospective cross-sectional multicentre clinical utility evaluation of two dual point-of-care tests in non-clinical settings for the screening of HIV and syphilis in men who have sex with men.

The evaluation of the utility of these dual tests in CBVCT services is of utmost importance as a result of a community-based voluntary, consultation, and testing service is among men with high acceptability among men who have sex with men. SD Bioline HIV/Syphilis Duo and Dual Path Platform HIV-Syphilis Assay are two of the two POCTs that will be evaluated. According to the manufacturers' instructions, Trained workers would obtain a capillary blood sample using finger prick blood to perform both POCTs. The feasibility of deploying the dual POCT for HIV and syphilis testing in MSM at CBVCT facilities will be explored by an analysis of the service's acceptability and usability among MSM customers and providers.

Source link: https://europepmc.org/article/MED/35676020


HIV, syphilis, hepatitis B and C in key populations: results of a 10-year cross-sectional study, Southern Brazil.

Methods The present study examined the seroprevalence of HIV, syphilis, and hepatitis B and C, as well as the epidemiological profiles of key and general populations tested at a reference public health center for sexually transmitted infections testing and counseling in the city of Curitiba, Southern Brazil. For HIV and syphilis, the most common age groups were 21-30 years old, HBV 21-40 years old, and HCV 41-60 years old. In the investigated key groups with a high prevalence of HIV and syphilis, men with sex with men, and transgender, a high prevalence of HIV and syphilis was found. Conclusion The steady rise of syphilis cases underscores the importance of targeted measures to raise adherence to condom use and minimize diagnosis and treatment for these key groups.

Source link: https://europepmc.org/article/MED/35674630


Determinants of syphilis infection among pregnant women attending antenatal care in hospitals of Wolaita zone, Southern Ethiopia, 2020.

The aim of this review was to determine determinants of syphilis infection among pregnant women attending antenatal care in hospitals in Southern Ethiopia's Wolaita zone. 2020 The risk of experiencing a maternal syphilis infection in pregnant women with more than one lifetime sexual partner [AOR = 3. 59, 95% CI] and a drug [AOR = 3. 3, 95% CI ] was higher in pregnant women with more than a single lifetime sexual partner [AOR = 3. 9, 95% CI ] and used a drug [AOR = 3. 39, 95% CI ]; in multivariate logistic regression; CI a [AOR = a sexually transmitted infections [AOR = syphites [AOR = a sexually transmitted infections [AOR = CI ]; Conclusion The determinant of syphilis in pregnant women was a sexual-related factors. To reduce syphilis infection, safe sexual behavior, raise awareness of the risk of STIs, and early detection and treatment of STIs are all required, as well as making the antenatal care service accessible for pregnant women.

Source link: https://europepmc.org/article/MED/35657978


Laboratory Evaluation of the DPP Syphilis Screen & Confirm Assay.

Since syphilis is a public health issue, new methods and methods for detecting active syphilis patients should be tested for future implementation. We reviewed the laboratory results of the DPP Syphilis Screen & Confirm rapid immunodiagnostic test, using visual inspection and the manufacturer's electronic test microreader, for the detection of treponemal and nontreponemal antibodies in 383 fully classified stored serum specimens. respectively, we used the Treponema pallidum particle agglutination test and rapid plasma reagin experiment as reference tests for the DPP Syphilis Screen & Confirm assay treponemal and nontreponemal components. The sensitivity was 96. 9% for either reading method and RPR titers of u22651:8, and numerical microreader results showed good correlation with RPR titers, despite limiting the analysis to RPR titers of u22651:8. Using serum, the DPP Syphilis Screen & Confirm assay demonstrated promising results, relative to reference syphilis tests. Importance Syphilis remains a public health issue, so health services must include screening techniques that enable a fast and accurate diagnosis to ensure appropriate treatment. Since finding no infrastructure to perform traditional syphilis testing in a variety of situations, the DPP Syphilis Screen & Confirm Assay simultaneously detects treponemal and nontreponetal antibodies, acting as an alternative for identifying cases in situations where there is no infrastructure to perform traditional syphilis testing, it is also important to get reports on the results of this technology in different scenarios. We believe that the use of the DPP Syphilis Screen & Confirm Assay with the microreader may assist in finding active syphilis cases and perhaps monitoring treatment responses in the field.

Source link: https://europepmc.org/article/MED/35638776


A completeness indicator of gestational and congenital syphilis information in Brazil

Objective On the Notifiable Disease Information System, assembles and verifies completeness metrics between 2007 and 2018. Pearson's correlation coefficients were used to validate the scores obtained by the weighted average method, relative to the principal component analysis results. According to the completeness scores estimated by the weighted average method and PCA, there was a strong linear correlation. Despite differences between regions, region of residence, and ethnic groups, improvements in the completeness of GS and CS notifications have been observed in recent years, underscoring the variables that determine the care score in comparison to the socioeconomic rankings, highlighting the variations in between regions, area of residence, and ethnic groups. The weighted average was a cost-effective methodological alternative to estimate data completeness scores, allowing for routine monitoring of the completeness of gestational and congenital syphilis data.

Source link: https://europepmc.org/article/PPR/PPR499849


Comparing adverse neonatal and maternal outcomes of chlamydia, gonorrhoea, and syphilis infections and co-infections in pregnancy.

Background: Although maternal sexually transmitted infections during pregnancy have been extensively investigated, no studies have reported or evaluated the relationship between STIs in pregnancy and maternal outcomes. Objectives: We are looking at the potential risks of adverse neonatal and maternal outcomes by examining ties between STIs and co-infections in pregnancy. Methods Ances: The 2019 U. S. natality files were used to determine the effects of STIs in pregnancy on adverse pregnancy outcomes. Conclusions The prevalence of preterm birth was increasing, particularly among those with a syphilis infection. Except for gonorrhoea and chlamydia co-infections, all STI groups, except gonorrhoea and chlamydia co-infections, were associated with an elevated incidence of gestational hypertension, with the strongest correlation among those with syphilis co-infections. Increased GH among those with STIs is a contributing cause of adverse pregnancy outcomes, according to new analysis into the causes and corresponding mechanisms of STIs in pregnancy.

Source link: https://europepmc.org/article/MED/35643891


A cross-sectional survey on attitudes of men who have sex with men towards anal self-examination for detection of anal syphilis.

According to studies, men who have sex with men practising receptive anal sex are more likely to have secondary syphilis, meaning primary anorectal lesions are likely to be missed. Among 66% who had never performed ASE, 68% would consider doing ASE in the future with a planned median frequency of 2 times per 4 weeks, but only ASE professionals were doing it at median 1 per 4 weeks. To determine the effectiveness of ASE for syphilis detection, research is required.

Source link: https://europepmc.org/article/MED/35624185

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions