Syphilis - Crossref

Clinical and Epidemiological Features of Syphilis in Pregnant Women: The Course and Outcome of Pregnancy

In 155 pregnant women infected with syphilis, 95 percent were unemployed, 47% were single; and 47% were unmarried. In 121 cases, Syphilis went without clinical manifestations. In 22 of the women, discordant results of the complement fixation test, precipitation test, Treponema pallidum immobilization test, and a fluorescent antibody test were found. In 75 cases, pregnant pathology was confirmed in 75 percent, and more often appeared as anemia in 49, who was stillborn in 46 and toxicosis in 44. In 23 cases, fetal ultrasonic stigmas of infection were present. In 3 cases, fetal hypoxia in 1, hypohydrosis in 2 cases, and hydropsy in 1 case were all present, Fetus development retardation was identified. The pregnancy pathology of women with syphilis was not considered not pathognomonic.

Source link: https://doi.org/10.1159/000052954

Syphilis Infection: An Uncommon Etiology of Infectious Nonimmune Fetal Hydrops with Anemia

In several industrial countries over the past decade, an increasing incidence of syphilis has been present in many developed countries. We present a case of non-immune fetal hydrops with anemia attributed to syphilis infection. The patient was treated with penicillin and the fetus developed an intrauterine red blood cell transfusion, but fetal death occurred immediately after. Such a presentation is mostly related to parvovirus B19, although syphilis etiology is little discussed because doctors have rarely encountered early congenital syphilis in the past.

Source link: https://doi.org/10.1159/000364804

Detection of Treponema pallidum in Skin Lesions of Secondary Syphilis and Characterization of the Inflammatory Infiltrate

Ten out of 24 specimens are T. pallidum positive using nested PCR, whereas none of them is T. pallidum positive using traditional silver staining. The presence of T. pallidum in the mucocutaneous lesions suggests that secondary syphilis mucocutaneous lesions could be triggered by direct T. pallidum invasion rather than an allergic reaction. In addition, the overwhelming number of inflammatory infiltrating cells in secondary syphilis is composed of CD45RO-positive T cells and CD68-positive macrophages, meaning that cellular immunity plays a key role in host reactions against T. pallidum infection in secondary syphilis.

Source link: https://doi.org/10.1159/000076479

Histologic Features of Secondary Syphilis

Background: Secondary syphilis is a sexually transmitted disease that is commonly referred to as u201cthe great imitatoru201d and has a wide variety of clinical manifestations. As a result, it is also vital to identify potential secondary syphilis patients with ambiguous clinical manifestation by pathology. Methods: We reviewed 59 biopsy samples from 56 patients with secondary syphilis. In 39 of 59 secondary specimens, neccrotic keratinocytes were identified. Plasma cells were the most common finding overall. The presence of Treponema pallidum was predominant at the dermal-epidermal junction. Conclusions: Necrotic keratinocytes are one of secondary syphilis' characteristic.

Source link: https://doi.org/10.1159/000502641

Hair and Scalp Manifestations in Secondary Syphilis: Epidemiology, Clinical Features and Trichoscopy

Objective: To investigate the clinical and dermoscopic characteristics of SA in patients with secondary syphilis and to determine the true prevalence. Methods: All patients with secondary syphilis were clinically and trichoscopically assessed in search of hair and scalp changes. Result: Five out of five patients diagnosed with secondary syphilis had SA. One patient with secondary syphilis had trichodynia that regressed precipitately following antibiotic therapy.

Source link: https://doi.org/10.1159/000431314

Clinical Aspects of Syphilis Reinfection in HIV-Infected Patients

The incidence of HIV-syphilis co-infection has increased since 2000, particularly among males having sex with men. Objective: To compare the cutaneous lesions seen with syphilis reinfections diagnosed with syphilis reinfections diagnosed in HIV-infected patients from the first stages. Methods: Syphilis reinfection was found both clinically and biologically in a cohort of HIV-infected patients by assessing changes in Venereal Disease Research Laboratory titers. Results: Among 533 HIV-infected patients and 42 others, 42, experienced their first syphilis infection in 1989. Conclusions: A high incidence of reinfection was observed, but there were less frequent skin infections during reinfection episodes.

Source link: https://doi.org/10.1159/000369617

Risk factors for syphilis in women: case-control study

OBJECTIVE OBJECTIVE: To the occurrence of syphilis in women treated at public maternity hospitals, researchers need to identify sociodemographic, socioeconomic, and health care causes relating to the occurrence of syphilis in women treated at public maternity hospitals. METHODS This is a case-control report examining women admitted to seven maternity hospitals in Recife, Brazil, from July 2013 to July 2014. CONCLUSIONS syphilis epidemic in women is linked to the occurrence of syphilis in women, and should be factored into the development of universal policies aimed at the prevention and control of syphilis, but in situations of greater vulnerability.

Source link: https://doi.org/10.11606/s1518-8787.2017051007066

A Prospective Study of the Influence of HIV Status on the Seroreversion of Serological Tests for Syphilis

Patients with HIV+ patients' syphilis after treatment is a major point of contention, with potential seroreactivation and illicit seroreversion. Compared to HIV+ male homosexuals with a history of treated syphilis, the aim of our study was to determine the long-term effects of STS in a cohort of HIV+ male homosexuals with a history of treated syphilis. Patients and Methods: Between 1986 and 1993, sixty-nine HIV+ male homosexuals with a documented history of treated syphilis and positive baseline treponemal tests were prospectively studied. Patients had a mean age of 38 years, a baseline CD4+ cell count of 578/mm 3 in a syphilis case that was elapsed for the first time since last syphilis, 7. 5 years, and a median follow-up of 4. 3 years. Even after adjustment for stage of syphilis, age, and time since the last episode of syphilis, time to seroreversion was shorter in HIV+ patients for the TPHA and FTA-Abs tests. The TPHA, FTA-Abs, and VDRL screening did not correlate to stage of syphilis, although the last episode of syphilis, age, or history of STDs in both groups was not significantly related to stage of syphilis. The TPHA and VDRL tests were not related to baseline CD4+ cell count and were not related to baseline CD4+ cell number. After adjustment for the CD4+ cell count, a significant decrease in titres was observed in HIV+ patients, including TPHA, FTA-Abs test, and VDRL, but this time only for TPHA, but not so for HIV+ patients. In HIV+ patients, TPHA can serorevert. Since therapy is ongoing in HIV+ patients, evolution of the VDRL test has occurred.

Source link: https://doi.org/10.1159/000018149

Predicting adverse pregnancy outcomes of pregnant mothers with syphilis based on a logistic regression model: a retrospective study

Abstract Objective: To determine whether a simple predictive model can be developed of risk factors leading to poor pregnancy outcomes in infants of syphilitic mothers during pregnancy, it can predict newborn APOs. Methods: We conducted a retrospective analysis of 768 pregnant women with syphilis. The results: Pregnancy women in the non-APOs group in comparison to the APOs group were involved in a longer treatment program. Conclusions: Our research found the effect of various aspects of syphilis pregnant women on pregnancy outcomes in Suzhou, as well as a prediction model of APOs.

Source link: https://doi.org/10.21203/rs.3.rs-1747566/v1

Syphilis incidence among men who have sex with men in China: results from a meta-analysis

One of China's most significant challenges is the rise of syphilis infections in men who have sex with men. This report aims to quantify the incidence of syphilis in MSM in China using meta-analysis. To summarize the overall incidence of syphilis, the use of STATA 12. 0 was used to analyze the incidence. According to the subgroup meta-analysis, incidence estimates were 38. 5/100 person-years, 12. 1/100 person-years, 11. 2/100 person-years, 8. 9/100 person-years, 8. 9/100 person-years, and 3. 1/100 person-years in Northeast, North, Southwest, East, South, and Northwest China, respectively. The prevalence of Syphilis among Chinese MSM is high, and this could increase the spread of other sexually transmitted diseases, including human immunodeficiency virus. Integrating syphilis surveillance services with HIV prevention strategies is vital. In China, public health response systems can be implemented to monitor and control the epidemic of syphilis and HIV.

Source link: https://doi.org/10.1177/0956462416638224

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