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The overwhelming number of Treponema genomics studies have been conducted on opportunistically obtained patient samples, with limited clinical data and patient connectivity metrics to date. Multiple samples per patient at various hospital sites have been collected and collected samples from MSM patients with an infectious syphilis disease outbreak. The TREPOLI research, which was carried out in Amsterdam, has been prospectively following and collecting samples from MSM patients with an infectious syphilis infection, including collecting multiple samples per patient at various body sites. We propose that the transition from primary to secondary syphilis is due to adaptive bacterial genomic mutations. We hypothese that this transition from primary to secondary syphilis is related to genetic mutations. To answer this question, we will use a combined case-control strategy, sequencing TPA from patients with primary and secondary syphilis in the same community in order to determine if there are signs of convergencent evolution as a result of disease progression. Aims and Objectives: To examine the genetic variations between T. pallidum causing primary and secondary syphilis.
Source link: https://www.ncbi.nlm.nih.gov/bioproject/803114
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