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Migraine is a common medical disorder characterized by throbbing headaches, nausea, photophobia, and phonophobia, among other signs. The goal of the current research was to produce solid lipid nanoparticles of sumatriptan succinate for brain targeting by nasal route. To improve the entrapment effectiveness of the hydrophilic drug, the Solvent injection method was used. SLNPs permeation in nasal mucosa was rapid, as indicated by brain targeting, according to an ex vivo diffusion study using goat nasal mucosa at pH 6. 8. After treatment with SLNPs, histopathology studies established the credibility of nasal mucosa. Sumatriptan succinate, a hydrophilic drug, can be successfully entrapped in SLNPs to the target brain via nasal delivery, and in this way, it could be a cost-effective solution to nose-to-brain delivery.
Source link: https://europepmc.org/article/MED/35703403
Sumatriptan succinate and prochlorperazine maleate are a clinically safe combination for treating migraines and associated nausea and vomiting. Classical oral dosage forms are not particularly effective in migraine due to the associated nausea/vomitting, and no safe fixed dose combination is available. Both film producer and plasticizer were created by solvent casting process using small amounts of polyvinyl alcohol and glycerol as film former and plasticizer, respectively, as well as fixed quantities of other components employing central composite design. According to 21 s and 2. 3 min, respectively, the most effective film demonstrated disintegration and total dispersion times. Both drugs were absorbed within 15 minutes of 100% permeation of both drugs by goat mucosa. In an optimized film, X-Ray diffraction and differential scanning calorimetry demonstrated drugs being amorphous and Fourier transform infrared demonstrated drug-excipient compatibility. A judicious combination of sumatriptan succinate and prochlorperazine maleate may be made in orodispersible films for the potential relief of migraines.
Source link: https://europepmc.org/article/MED/35655105
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