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Sumatriptan - Crossref

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Last Updated: 02 August 2022

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Metoclopramide versus sumatriptan in the treatment of migraine in the emergency department: a single-center, open-label, cluster-randomized controlled non-inferiority trial

Abstract Background Migraine is a common disorder seen in the emergency department, with a common symptom. In this review, we will investigate whether metoclopramide 10 mg intravenously is non-inferior to sumatriptan 3 mg subcutaneously as migraine relief in the ED. Methods This research is a single-center, open-label, cluster-randomized controlled trial of 80 patients with migraine attacks to find out why metoclopramide has a non-inferiority to sumatriptan. Discussion if our hypothesis is correct, metoclopramide can be used as the first-line treatment for migraine attacks in ED settings.

Source link: https://doi.org/10.21203/rs.2.12178/v1


Subcutaneous sumatriptan: association with decreases in postoperative pain and opioid use after elective cranial surgery

There is little research into the safety and effectiveness of sumatriptan for postcraniotomy pain management. Following elective craniotomy, this research sought to determine whether subcutaneous sumatriptan is a safe and effective pain management tactic. Patients with and without sumatriptan administration were compared in pain scores, intravenous, and or oral opioid use. Patients with and without sumatriptan administration had no significant differences in baseline characteristics or surgical type, according to the authors. Both adult and pediatric patients, the maximum dose of intravenous opioid use, length of intravenous opioid use, maximum dose of intravenous opioid use, maximum dose of intravenous opioid use, oral opioid use, length of oral opioid use, and maximum dose of oral opioid used were all reduced. CONCLUSIONS Since craniotomy, the authors developed subcutaneous sumatriptan as a safe and effective tool for postoperative pain relief. Large multicenter randomized controlled trials are required to further investigate the specific role of sumatriptan in postoperative pain relief after craniotomy.

Source link: https://doi.org/10.3171/2019.10.jns192503


Effects of Neuropeptides on the Sumatriptan-Disturbed Circulation in the Optic Nerve Head of Rabbits

The aim of this research was to investigate the vascular responses of retinal rabbits in New Zealand white rabbits to substance P, neurokinin A, neurokinin B, senktide, capsaicin, and calcitonin gene-related peptide before and after selective antagonist administration. In the rabbit's optic nerve head, we investigated the effects of these neuropeptides on the normal circulation. The relaxing effect is expressed in percentages corresponding to the precontracted vascular diameter. The SP dose-response curve was adjusted to the right after the perivascular preinjection of 1 nmol/l L-668,169 or 1 nmol/l L-733,060. The NK3 receptor agonists had a minor vaping effect. The presence of NK1, NK2, and CGRP receptors on the rabbit's retinal arteriolar wall has been shown for the first time.

Source link: https://doi.org/10.1159/000074978


Calcium-Antagonistic Activity of Sumatriptan in the Rat Anococcygeus Muscle

It was investigated what the rat anococcygeus muscle relaxed after sumatriptan, a 5-HT 1B/1D receptor agonist, felt on the rat anococcygeus muscle. The basal rate of cAMP manufacture in membranes derived from the rat anococcygeus muscle was 4. 77 % (mg protein/min), according to u00b1 0. 02 pmol/min. 5-HT 1B, 5-HT 1D, and 5-HT 7 receptors were not present in the rat anococcygeus muscle, according to the mRNA expression. Sumatriptan, according to the study, promotes muscle relaxation in the precontracted rat anocygeus muscle by a calcium-antagonistic function.

Source link: https://doi.org/10.1159/000056149


Tachyphylaxis to the Sumatriptan-Induced Contractile Effect in the Human Uterine Artery but Not in Human Cerebral Blood Vessels: Pharmacological Demonstration of the 5-HT 1B Receptor Functionality Loss

The human uterine artery's sumatriptan's in vitro contraction response was similar to that of human cerebral blood vessels. At 0 and 24 h after uterine artery isolation, we were able to test 5-HT 1 receptor subtypes' functionality, concentration-response curves to sumatriptan were used to investigate 5-HT 1 receptor subtypes' functionality, and reaction curves to sumatriptan. Both 10 mol/l cyanopindolol and 63 nmol/l SB 224,289 were antagonized by sumatriptan's onset at 0 h, but not after 24 h of uterine artery isolation.

Source link: https://doi.org/10.1159/000334930


Involvement of Cannabinoid Type 2 Receptors in the Favorable Effects of Sumatriptan on the Random-Pattern Skin Flap Survival in Rats: A Novel Potential Target

Rats have survived by random-pattern skin flap survival, determining the potential involvement of CB2 receptors in the anti-inflammatory effects of sumatriptan's anti-inflammatory effects. Methods: 36 male Wistar rats were randomly divided into 6 research groups in a controlled experimental study. Sumatriptan 0. 3 mg/kg in all macroscopic and microscopic studies compared to the control group remarkably increased the skin flap survival in all macroscopic and microscopic experiments. In rats treated with sumatriptan 0. 3 mg/kg compared to the control group, IL-1, TNF-u03b2 and TNF-u03b1 were significantly reduced, and CB2 receptor expression in skin cells was elevated. Conclusion: We discovered that CB2 receptors play a vital role in the successful effects of sumatriptan on skin flap survival as a novel mode of action. So, targeting these receptors in skin flap surgery seems to be a safe way to ensure its longevity and avoid tissue necrosis.

Source link: https://doi.org/10.1159/000521581


Almotriptan in Migraine Patients Who Respond Poorly to Oral Sumatriptan: A Double-Blind, Randomized Trial

Background: Poor response to sumatriptan therapy for acute migraine attacks has been documented in the literature, but no controlled trials have investigated the safety of an alternative triptan in this subgroup of patients. Patients with an International Headache Society diagnosis of migraine who self-described as having at least two unsatisfactory responses to sumatriptan were also treated for their first migraine attack with open-label sumatriptan 50 mg, giving them a long-free range of pain and a long-term relief from pain. Almotriptan 12. 5 mg is an affordable and well tolerated alternative for patients who respond poorly to sumatriptan 50 mg, but it does not predict a poor reaction to other agents in the class.

Source link: https://doi.org/10.1159/000085061


Efficacy of 1,000 mg Effervescent Acetylsalicylic Acid and Sumatriptan in Treating Associated Migraine Symptoms

Within 2 hours after starting the study drug, the key endpoint was the percentage of patients with complete remission of the three accompanying symptoms: nausea, photophobia, and phonophobia. All three accompanying signs were present in patients treated with ASA, 43. 8% of patients treated with sumatriptan, and 30. 9% of patients treated with placebo showed complete recovery of all three accompanying signs. For ASA, 48. 8% for sumatriptan, and 32. 9% for placebo, there were 43% of patients with headache relief from moderate to severe to mild or no pain. At 2 h, drug-related adverse events in 3. 9, 4. 7, or sumatriptan were reported in 4. 7, 24. 4, and 14. 5 percent of patients treated with ASA, sumatriptan, or placebo. The study found that administering effervescent ASA results in nausea, photophobia, and phonophobia, as well as migraine headache reduction, which is comparable to sumatriptan.

Source link: https://doi.org/10.1159/000079544


Comparison of Preference for Rizatriptan 10-mg Wafer versus Sumatriptan 50-mg Tablet in Migraine

In the treatment of a single migraine attack with each therapy, this randomized, open-label, crossover outpatient study found the preference of 481 patients for rizatriptan 10-mg rapidly disintegrating tablets versus sumatriptan 50 mg tablets. Almost twice as many patients preferred rizatriptan 10-mg rapidly disintegrating tablet to sumatriptan 50-Mg tablet, rather than sumatriptan 50-mg tablet. With rizatriptan and 66. 6% with sumatriptan, headache relief was 79% at 2 h and sumatriptan, with rizatriptan and 66. 6% with sumatriptan, with rizatriptan being superior to sumatriptan within 30 min of dosing. Patients were pain-free 2 h after rizatriptan, compared to 42. 1% treated with sumatriptan, rizatriptan being superior within 1 h of therapy. Patients taking rizatriptan were pain-free at 2 h and had no recurrence or need for additional medications, relative to 32. 3% of patients on sumatriptan. Patients were more satisfied 2 hours after receiving sumatriptan therapy than 2 hours after starting treatment with sumatriptan.

Source link: https://doi.org/10.1159/000052143


Fabrication and Characterisation of Lavender Oil and Plant Phospholipid Based Sumatriptan Succinate Hybrid Nano Lipid Carriers

BACKGROUND: Sumatriptan Succinate's nanostructured Lipid Carriers were created by using lavender oil. Lavation oil was used to treat a migraine in ancient times. In a nano-formulation, the natural anti-migraine agent, lavender oil, in combination with an anti-migraine drug such as SS, will be a viable alternative to migraine therapy. Methods: The central composite design technique was used to investigate the relationship between independent variables and responses such as lavender oil and LECIVA-S70. SNE9's best formulation had an average diameter of 398. 8. nm, with a PDI of 0. 216, and a potential for reproducible drug release profiles. According to ANOVA, the PDI R2 is significant in the central composite design, according to ANOVA.

Source link: https://doi.org/10.18502/pbr.v6i1.3430

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions