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Following a thorough inquiry, which includes the completion of a complete autopsy, investigation of the medical history, and analysis of the clinical history, Sudden infant death syndrome is defined as the sudden death of an infant younger than one year of age. Not only ALTE and BRUE, but also SIDS are reported in a literature review, but also SIDS. SIDS are not recommended for children with previous ALTE or severe BRUE, or those at risk of developing these conditions. However, after proper preparation and instruction in their use, family members will know the benefits and drawbacks of these devices, and not the limitations, according to their use. ".
Source link: https://doi.org/10.3390/life12060883
"Abstract Increasing evidence shows that brain edema may play a vital role in sudden infant death syndrome pathogenesis," indicating that variants of genes for cerebral water channels may be linked to SIDS. Comprehensive studies have established the role of the sulfonylurea receptor 1u2013transient receptor potential melastatin 4 non-selective cation channel in cerebral edema. We hypothesized that variants of the SUR1-TRPM4 channel complex's genes may have been related to SIDS. In 185 SIDS cases and 339 controls, twenty-four polymorphisms in candidate genes involved in the SUR1-TRPM4 non-selective cation channel were investigated.
Source link: https://doi.org/10.1007/s00414-022-02819-9
"AbSTRACT: Background: Although the cause of sudden infant death syndrome is unclear, one of the key hypotheses is that a subtle abnormality in respiratory circuitry is a significant underlying cause. Comparison of the normal developing vagus nerve with nerves in SIDS patients indicates changes in the nucleus tractus solitarius and dorsal vagular nucleus as well as in the peripheral vagus nerve. Although the reason for the delayed vaping maturation in SIDS is unclear, the occurrence of astrogliosis in the region of the vaping nuclei is consistent with an exposure to hypoxic-ischemic events some time before death.
Source link: https://doi.org/10.1017/s0317167100039147
"Using the nucleator estimator method, the mean neocortical nuclear volume was estimated in sudden infant death syndrome cases [10 normal birth weight and ten low birth weight cases classified by birth weight for gestational age] and compared to ten NBW control cases. Both the control and SIDS LBW cases increased mean nuclear volume with age; the SIDS NBW cases showed no change. ".
Source link: https://doi.org/10.1159/000047119
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