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The center of mass of three shots were identified in the 3D image space by implementing an iterative localization algorithm and serving as the tested control points for MRI distortion detection. Using a spatially co-registered image processing device, MRIs and CT images were spatially co-registered. The inverse transformation matrix was applied to the reference control points and compared with the corresponding MRI-identified ones to determine the overall spatial reliability of the MRI/CT dataset's global spatial resolution. Increased MRI distortion was found in areas far away from the MRI center, according to median radial deviation of 0. 76 percent. The mean image distortion correction improves geometric precision, but residual distortion cannot be considered negligible. A statistically significant positive correlation between detected spatial offsets and their distance from the MRI isocenter was found in all three datasets.
Source link: https://doi.org/10.1371/journal.pone.0268925
Introduction The development of advanced radiation therapy delivery methods needs a greater understanding of the various planning sequences and methods. The aim of this research was to determine the best possible method to provide stereotactic radiosurgery between dynamic conformal arc techniques employing various methods including DCA, DCA + SSO, and DCA + SSO + VDR using noncoplanar beam arrangement and volumetric modulated arc therapy using coplanar beams. Methods and Methods Submitted in this dosimetric study 11 brain cases were retrospectively planned for various techniques and evaluated for the Paddick conformity index, radiation therapy Oncology Group's homogeneity index, Paddick gradient index, monitoring time, and average brain dose in terms of monitor units and average brain dose. If VMAT is not available in the facility, the DCA + SSO + VDR technique, which uses non coplanar beams, can be used to deliver SRS therapy.
Source link: https://doi.org/10.1055/s-0042-1751117
Abstract Background The distinction between true disease progression and radiation necrosis following stereotactic radiosurgery to intracranial metastases is a common yet difficult clinical situation. Case presentation Assessment should go beyond simply the lesion's appearances at a certain time point, but also consider local anatomy and lesion evolution. The treatment lesion is largely concentric about the treatment lesion, while stereotactic radiosurgery's radiation dose does not follow these anatomical boundaries and is mainly concentric around the treated lesion. Secondly, the dynamic nature of radiation necrosis may result in a change in lesion appearance, with two parts of the lesion both enlarging and regressing. And if the total lesion expands, regression of a part of a lesion shows radiation necrosis. Conclusions The difference between true disease progression and radiation necrosis should go beyond the appearances of the lesion.
Source link: https://doi.org/10.1186/s40644-022-00470-6
Stereotactactic Radiosurgery is a specialized radiotherapy treatment for Arteriovenous Malformations in which Computed Tomography images are used for dose estimation. The aim of this research was to look at CT image distortions caused by embolic agents and determine the effect of these distortions on dose determinations. Methods: Before SRS, eight AVM patients were treated with embolic agents, according to AVM's. The most significant result of artefact masking, u22121. 3% with embolic masking, u22124. 7% with embolic masking, and u22124. 5% with artefact-free diagnostic images, according to patient-centric plans, u22124. 4% with whole brain masking, u22121. 4% with embolic masking, u22124. 7% with artefact masking, u22124. 3% with embo Gamma pass rate for both embolic agents with conformal fields and 99. 9% with dynamic arcs was 96% in phantom. To individual patients'u2019 plans, we recommend investigating the effect of embolic substances on individual patients. The entire brain and diagnostic CT images can be used to determine the amount of dose reduction caused by embolic substances and correct it if necessary.
Source link: https://doi.org/10.1016/j.phro.2022.06.014
In the literature on the treatment of nonvesibular schwannomas, radiation-associated secondary malignancy/malignant transformation has not been described. Setting The patient was a 52-year-old man with an enlarging high cervical/skull base lesion 8. 5 years after CyberKnife treated a suspected vaping schwannoma as a result of the patient's vaping schwannoma. The final pathology diagnosis was a malignant peripheral nerve sheath tumor. Patient had a gross total resection, according to the results. He received fractionated radiation of 50 Gy in 25 fractions and a boost gamma knife radiosurgery of 10 Gy to the 50% isodose surface three months after resection. Conclusions Nonvestibular schwannomas treatment may cause nonproductive change, which could lead to malignant change.
Source link: https://doi.org/10.1055/s-0033-1358797
Abstract Background: Stereotacitc radiosurgery has risen to prominence as an alternative therapeutic option for jugular foramen schwannomas in recent years. Methods in this retrospective review were included among all patients with JFS who have undergone at least six months of follow-up between July 2008 and November 2019. During the follow-up period, thirteen of 16 patients' improvement eAE symptoms were present during the follow-up period, and the median resolution time was six months. The difference between the initial tumor volume and the transient expansion volume was more prominent in the patients with eAEs in 11 of 16 patients with eAEs, with a median of 3. 6 months. Although acute adverse events following SRS for JFS are not uncommon, these acute symptoms were not short-lived and most improved with the steroid therapy.
Source link: https://doi.org/10.1186/s13014-022-02057-8
In groups 2 and 3 compared to group 1, a multivariable Cox proportional hazards regression analysis was carried out to produce adjusted hazard ratios and their 95% CIs for local recurrence. We included the results of 248 patients with nonfunctioning pituitary macroadenomas. The aHRs for stroke risk in groups 2 and 3 were 0. 37 and 0. 51 respectively, according to a multivariable Cox proportional hazards regression study. Conclusion: SRS and transsphenoidal surgery for nonfunctioning pituitary macroadenoma therapy have similar toxicity profiles. However, a new FRT for non-functioning pituitary macroadenoma treatment could potentially raise stroke risk.
Source link: https://doi.org/10.3390/cancers11111658
We compared plan quality between Brainlab Elements Multiple Brain Metastases software that uses dynamic conformal arc therapy and Varian HyperArc applications using a volumetric modulated arc therapy method in this review. Patients and methods were retrospectively reviewed between July 2018 and April 2021, 36 consecutive patients u2265, 18 years old with 367 metastases who received SIMT SRS at UPMC Hillman Cancer San Pietro Hospital, Rome, were retrospectively assessed. Both the cumulative tumor volume and planning tumor volume were 1. 33 cm3 and 3. 42 cm3, respectively. Both Elements MBM and HA services were able to produce high-quality plans in patients with up to 25 brain metastases. DCAT studies were more effective in terms of normal brain sparing, especially in patients with more than ten lesions and limited total tumor volume.
Source link: https://doi.org/10.1186/s13014-022-02086-3
ObjectiveGamma knife staged stereotactic radiosurgery has been an effective treatment for large brain metastases,; however, it has been difficult to determine the total dose due to tumor shrinkage between two staged sessions. paraphrasedoutput:MethodsPatients treated with GK Staged-SRS in a single institution were retrospectively included in this review in the aim of determining total biological efficient dose in Staged-SRS and hypofractionated SRS. In Staged-SRS, despite the larger PTVs and brain V84Gy2 in the HF-SRS plans, lower HF-SRS's budgets remained lower. ConclusionOvertheConclusionWe introduced an algorithm to determine the composite BEDs delivered to both tumor and normal brain tissue. Staged-SRS delivers a higher dose of tumor in comparison to SF-SRS but maintains a similar dose to normal brain tissue.
Source link: https://doi.org/10.3389/fonc.2022.892139
Stereotactic radiosurgery for brain metastases has risen, prompting the reassessment of whole brain radiation therapy. Patients with BM at the time of cancer diagnosis were treated to a pattern of care analysis of SRS and WBRT dose-fractionations. Methods and Materials: The National Cancer Database found adults with BM at cancer diagnosis from 2010 to 2015, but no prior malignancy was found in the National Cancer Database. 90,388 adults with first lifetime cancer had BM at first diagnosis, with 4,087,967 adults with their first lifetime cancer. WBRT use decreased from 27. 8% to 23. 5% of newly diagnosed patients, and SRS increased from 8. 7% to 17. 9%. For SRS, the lowest dose-fractionations were 30 Gy in ten fractions for WBRT and 20 Gy in a fraction.
Source link: https://doi.org/10.1016/j.adro.2019.07.012
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