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Stereotactic radiosurgery has delivered promising results in terms of local tumor control and survival of patients with choroidal melanoma. At the same time, there are virtually no studies that attempt to determine the correlation of SRS complications in terms of the initial characteristics of the tumor and dose physiology of radiosurgery. The prospective research included 43 patients with cT3N0M0 choroidal melanoma. At a 50 percent isodose margin, the median prescribed dose per tumor margin was 30 Gy. Secondary cataract after SRS developed in 4 cases, post-radiation retinopathy, secondary retinal detachment, and secondary glaucoma in 6 cases, with secondary glaucoma occurring in 7 cases. In 90. 7% of patients, the eyeball was preserved after SRS during the observation period. There were no cases of secondary glaucoma in this case, with a tumor volume less than this one. Secondary glaucoma appeared in 71% of cases in the case of tumors with a volume equal to or greater than the estimated amount. During the observation period, the incidence of secondary glaucoma was less than 5%, with a tumor thickness greater than this measure - 72%. Radiosurgery as a monomethod is not recommended in the treatment of tumors with a volume greater than or equal to 800 mm3 or more than a thickness of more than or equal to 7. 6 mm is not advised; instead, a combined approach, including tumor endoresection, is recommended.
Source link: https://doi.org/10.25298/2221-8785-2022-20-3-335-342
Abstract OBJECTIVE : Stereotactic radiosurgery is a common therapeutic technique to treat brain metastases. The BM dimension is considered a relevant topic in the SRS therapeutic results, according to a recent study. This research was conducted to determine determinants of BM after SRS and pinpoint causes related to patients and BM leading to local recurrence. METHODS : This study included patients with BM from non-small cell lung cancer who had been sequentially treated with SRS from 2010-2015. After 12 months of SRS, the results revealed a non-cystic BM and a brain left sided BM as features that are related to increased progression free survival. CONCLUSION : Considering pharmacology in patients with BM, the connection between initial volume and failure within 12 months after SRS had no statistical significance, a BM located on the right side of the brain showed therapeutic failure within 12 months after SRS.
Source link: https://doi.org/10.21203/rs.3.rs-1427975/v2
Abstract OBJECTIVE: Stereotactic radiosurgery is a safe and effective medical treatment for brain metastases. A current discussion highlights the BM dimension as an important factor in SRS therapeutic success. paraphrasedoutput:METHODS: This research sought to assess BM after SRS and determine factors related to patients and BM leading to local recurrence in 2010-2015. Lesions that resulted in therapeutic improvement and local recurrence were identified after determining the exact time sequence of BM in time progression. CONCLUSION: Considering therapeutics in patients with BM, the correlation between initial volume and failure within 12 months after SRS had no statistical significance, BM located on the right side of the brain demonstrated therapeutic failure within 12 months after SRS.
Source link: https://doi.org/10.21203/rs.3.rs-1427975/v1
BACKGROUND Skull base meningiomas often have diplopia as a result of the abducens cranial nerve compression. To determine if Gamma Knife surgery resulted in relief of their symptoms, the authors looked at the results in 13 patients with SBMs who were experiencing diplopia. OBSERVATIONS Fourteen patients who were diagnosed with SBMs in the cavernous sinus, clivus, or petroclival regions, as well as diplopia were treated by GKS. The median number of time with diplopia before GKS was 1. 5 months among patients with documented postradiosurgical success.
Source link: https://doi.org/10.3171/case225
Object Stereotactically guided radiosurgery is one of the most common treatment techniques for patients with acoustic neuromas. The aim of radiosurgery is to stop tumor formation while also preserving neurological function. Because of the danger of complete deafness, patients with acoustic neuromas associated with neurofibromatosis Type 2 pose a unique challenge. The mean tumor volume at radiosurgery was 4. 8 ml and the mean tumor margin dose was 15 Gy. Following radiosurgery, surgical resection was performed in three patients after radiosurgery; only one showed radiographic evidence of progression. In 25 of 31 patients, normal facial nerve function was preserved. In 34 of 36 patients, normal trigeminal nerve function was preserved. Conclusions Stereotactically guided radiosurgery is a safe and effective therapy for patients with acoustic tumors in the context of NF2. With radiosurgery, preservation may be more effective than with other commonly available methods.
Source link: https://doi.org/10.3171/foc.19188.8.131.52
OBJECTIVE The majority of brain metastases that recur after stereotactic radiosurgery remain scarce. METHODS The authors recount the collective experience of 4 hospitals where the treatment of BMs that recurred after SRS was performed with stereotactic laser ablation was performed. SLA RESULTS Twenty-six BMs that recurred after SRS were treated with SLA have recurred. In BMs in which 80% ablation had been achieved, 80% ablation was achieved, but no disease progression was observed in BMs in which 80% ablation was achieved. Despite ablation rates of 80%, no disease progression was noted in these patients, indicating that adjuvant hypofractionated SRS improves SLA's efficiency. CONCLUSIONS Stereotactic laser ablation is an effective treatment option for BMs in which SRS does not work properly.
Source link: https://doi.org/10.3171/2016.7.focus16227
Methods Based on a retrospective chart review, 279 patients were treated with SRS for meningiomas between January 1999 and March 2011 at Wake Forest Baptist Health, Wake Forest Baptist Health. At 1, 3, and 5 years, respectively, local control rates for WHO Grade I tumors were 96. 6%, 84. 4%, and 77%. Both 1, 3, and 5 years ago, respectively, found that local control rates for Grade II and III tumors in WHO Grade II and III tumors were 72. 3%, 57. 9%, and 59% at 1, 3, and 53 percent. Doses greater than or equal to 12 Gy were also associated with improved local control, according to multivariate analysis. Conclusions 12 Gy was the minimum recommended margin dose for the treatment of meningiomas in this patient study. Male sex is a risk factor for distant failure, according to high-grade histology and multifocal disease, local failure is a risk factor for local failure.
Source link: https://doi.org/10.3171/2013.8.focus13283
Stereotactic radiosurgery and stereotactic radiotherapy have been used as a primary treatment or adjuvant to resection in the treatment of intracranial meningiomas. SRS and SRT in patients with primary or recurrent ICMs are compared in terms of their safety and long-term effectiveness. SRS versus SRT for the treatment of ICMs in adult patients was included in randomized controlled trials, case-control studies, and cohort studies comparing SRS versus SRT for the treatment of ICMs in adult patients. 0. 73 percent CI 0. 73, 0. 9 percent [u20131. 40], p = 0. 72, p = 0. 72. The radiographical tumor control at the last follow-up was much worse in patients who underwent SRS than SRT odds ratio [OR] 0. 47, 95% confidence interval [CI] 0. 27, 0. 94%, 0. 9 percent; 0. 72] 0. 76 percent, p = 0. 72; p = 0. 72. The radiographic tumor control was greater achieved by FSRT OR 0. 46, 95% CI 0. 6, 0. 76, p = 0. 76, compared to SRS. p = 0. 003 with respect to SRT, while SRT leads to a significant risk of clinical neurological instability during follow-up OR 2. 07, 95% CI 1. 06u20134. 06, p = 0. 03 and a 0. 003 for immediate symptomatic edema OR 4. 58, 93 percent CI 1. 06u201312. 56, p = 0. 003 with respect to SRT. CONCLUSIONS SRS and SRT are both viable options for ICMs administration. However, SRT has a higher radiographic tumor control rate and a reduced risk of post-treatment symptomatic deterioration and symptomatic edema with respect to SRS.
Source link: https://doi.org/10.3171/2019.3.focus1970
Following radiosurgical treatment of a meningioma, the authors discuss a rare case of radiosurgery-induced glioblastoma multiforme. Following surgical removal of a WHO grade II meningioma, a 74-year-old patient with a sporadic meningioma underwent radiosurgery. This is the third case of GBM after SRS for a meningioma, as far as the authors are aware.
Source link: https://doi.org/10.3171/2019.3.focus1948
OBJECTIVE OBJOBJ OBJOBJOBJOBJ OBJ OBJOBJ OBJECTIVE OBJ OBJUROBJ OBJ OBJOR OBJORD OBJECTIVE OBJOC OBJECTIVE OBJOBJECTIVE OBJUROBJECTIVE OBJOCCOBJOCOCCULOBJECTIVE OBJECTIVE OBJURABOUTput: OBJECTIVE OBJOCDE INTENTION OBJECT Established inclusion criteria were used to screen all identified relevant articles that were published before September 2017 without a backward date limit. The estimated rate of overall tumor control in the pooled rate was 93. 9% with a weighted mean follow-up of 46 months. In just 13 of 18 patients who received initial medical failure, Salvage therapy was indicated. Functional facial nerve regeneration was achieved in 96. 1% of patients, according to the House-Brackmann grading system. CONCLUSIONS A combined approach of STR and SRS was shown to have excellent clinical and functional results while still achieving a tumor control rate comparable to that obtained with total resection.
Source link: https://doi.org/10.3171/2017.12.focus17669
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