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It's unclear how long-term effects of autologous hematocell stem cell transplantation on renal health, as well as the effects of renal function on progression-free survival and overall longevity in patients with multiple myeloma are unknown. To determine correlations between the eGFR, PFS, and OS, we used linear mixed effect models to investigate the change in estimated glomerular filter rate and a joint model approach to investigate interactions between the eGFR, PFS, and OS. Although there is a modest decrease in eGFR post-ASCT, this does not have an effect on PFS or OS, according to this report. POINTS KEY POINTS A MM stage at diagnosis was correlated with reduced eGFR at all stages of chronic kidney disease. In any of the studies, eGFR was not related to PFS or OS, but disease-related causes leading to reduced eGFR, PFS, and OS were all associated with reduced eGFR, PFS, and OS. ASCT did not adversely affect kidney function and minimized the risk of CKD in MM outcomes.
Source link: https://doi.org/10.1080/10428194.2020.1797719
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