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Multiple myeloma patients' long-term effects of autologous hematocell stem cell transplantation on renal function, as well as the effects of renal function on progression-free survival and overall survival in patients with multiple myeloma are uncertain. To investigate relationships between the eGFR, PFS, and OS, we used linear mixed effect models to investigate the change in estimated glomerular filtration rate and a joint model approach to investigate correlations between the eGFR, PFS, and OS. There was no correlation between eGFR and PFS or OS. KEY POINTS Advanced MM stage at diagnosis was associated with decreased eGFR in all stages of chronic kidney disease. In any of the reports, eGFR was not related to PFS or OS, but disease-related causes leading to reduced eGFR, PFS, and OS were all associated with decreased eGFR, PFS, and OS. ASCT did not adversely influence kidney function and minimized the risk of CKD in MM outcomes.
Source link: https://doi.org/10.1080/10428194.2020.1797719
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