Advanced searches left 3/3

Stem cell Function - Springer Nature

Summarized by Plex Scholar
Last Updated: 27 July 2022

* If you want to update the article please login/register

Acetyl-CoA-Carboxylase 1-mediated de novo fatty acid synthesis sustains Lgr5^+ intestinal stem cell function

The function of intestinal epithelial cells is affected by a variety of fatty acid metabolism basic steps. However, although the role of cellular fatty acid oxidation is well known, it is not clear how de novo fatty acid synthesis influences IECs' biology. We report here that interfering with de novo FAS by deletion of the enzyme Acetyl-CoA-Carboxylase 1 in IECs results in epithelial crypt structures and a specific decrease in Lgr5+ intestinal epithelial stem cells. Eventually, inhibition of ACC1 reduces the growth of tumors in colitis-associated colon cancer, raising the importance of cellular lipogenesis for maintaining ISC function and providing a potential solution to colon cancer therapy.

Source link: https://doi.org/10.1038/s41467-022-31725-2

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions