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Spectrum - PubMed

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Last Updated: 09 September 2022

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Advanced aromatic organic compounds removal from refractory coking wastewater in a step-feed three-stage integrated A/O bio-filter: Spectrum characterization and biodegradation mechanism.

A major route for non-biodegradability of coking wastewater is a syringe of aromatic organic compounds. For optimizing the design and operation of COW biological treatment systems in practical applications, a deep understanding of bio-degradation of AOCs is vital. Anoxic zones mainly removed Phenol and indole, but quinoline and pyridine removal occurred in both anoxic and aerobic zones. Tryptophan and humic acid with high molecular weight demonstrated significant change and elimination with three-dimensional fluorescence spectral weight. Using a step-feed multi-stage alternating anoxic/oxygen treatment system, this paper provides detailed information on AOCs biodegradation.

Source link: https://doi.org/10.1016/j.jenvman.2022.116140


Inebilizumab: A Review in Neuromyelitis Optica Spectrum Disorder.

Inebilizumab is a newly approved monoclonal antibody for use in adults with neuromyelitis optica spectrum disorder who are anti-aquaporin-4 antibody seropositive. Inebilizumab blocks B cell biogen CD19, which ineffectively depletes circulating B cells, effectively killing inflammatory NMOSD attacks that are potentially disabling or life-threatening. In the pivotal phase 2/3 N-MOmentum study, inebilizumab reduced the risk of NMOSD attacks relative to placebo, particularly in AQP4-antibody seropositive patients. During the open-label extension, the treatment effect on relapse risk and disability scores in inebilizumab-treated patients was maintained, with a score of 0 to 66 percent.

Source link: https://doi.org/10.1007/s40263-022-00949-7


Short-Term Benzalkonium Chloride (C12) Exposure Induced the Occurrence of Wide-Spectrum Antibiotic Resistance in Agricultural Soils.

Antigenetic resistance is believed to be under increasing selection pressure. Using high-throughput quantitative PCR and Illumina sequencing, we established short-term soil microcosms to investigate ARG profile dynamics in agricultural soils amended with sulfamethazine and gradient concentrations of BC. With the rise in BC content, the number of ARGs found in the soil increased, but the normalized ARG abundance decreased. Low-medium BC exposure concentrations resulted in the development of small but high ARG co-occurrence clusters in the soil, according to Network analysis, while high BC exposure level led to a higher incidence of ARGs.

Source link: https://doi.org/10.1021/acs.est.2c04730


Broad-Spectrum Inhibitors against Class A, B, and C Type β-Lactamases to Block the Hydrolysis against Antibiotics: Kinetics and Structural Characterization.

The emergence of antibiotic resistance has resulted in a global crisis for the physician to tackle infection control concerns. Although several novel u03b2-lactamase inhibitors are being evaluated or are in clinical trials, the coverage of their activity spectrum does not include MDR organisms that are producing multiple classes of u03b2-lactamases at a single time. Assay was carried out to determine the toxicity of screen lead molecules using a 3--2,5-diphenyl tetrazolium bromide assay. All three tested inhibitors, including class A, B, and C type u03b2-lactamases, were found to reduce MIC and demonstrated excellent compatibility against all the SBLs and MBLs produced by class A, B, and C type u03b2-lactamases. These inhibitors can be used as a future drug candidate in combination with antibiotics as a single solution to fight infections caused by resistant strains. However, there is no commercially available broad-spectrum u03b2-lactamase inhibitor that targets both MBLs and SBLs.

Source link: https://doi.org/10.1128/spectrum.00450-22


Tissue-wide cell-specific proteogenomic modeling reveals novel candidate risk genes in autism spectrum disorders.

Autism spectrum disorders are a group of multi-dimensional neurodevelopmental disorders associated with repeating behavioral patterns and communication difficulties. A list of prospective ASD risk genes was assembled using a systems biology approach called MAPSD for joint proteome dynamics modeling and a large number of omics datasets. In addition, we developed a detailed subcellular localization enrichment map of the known and the identified genes from 32 micro-domains, revealing that neural cells and neuropils account for the largest amount of signal enrichment in cerebral cortex. Moreover, we found that ASD risk genes are mainly present in such human interactome modules, and that the identified genes may serve as the regulator for some of the common ASD loci.

Source link: https://doi.org/10.1038/s41540-022-00243-8


Directed reconstruction of a novel ancestral alcohol dehydrogenase featuring shifted pH-profile, enhanced thermostability and expanded substrate spectrum.

The T1550 and Tm values of A64 were 57. 5°C and 61. 7°B0C, much higher than those of the descendant counterpart. The A64's quantitative spectrum was measured with a Shannon-Wiener index of 2. 38, more developed than D10, and in Group A and B, A64, which exhibited greater enantioselectivity, with bulky ketones showing higher enantioselectivity. This research reveals an effective way to produce ancestral enzymes and an efficient ancestral enzyme with industrial significance for asymmetric synthesis of chiral alcohols.

Source link: https://doi.org/10.1016/j.biortech.2022.127886


Fecal Carriage of Extended-Spectrum β-Lactamases and pAmpC Producing Enterobacterales in an Iranian Community: Prevalence, Risk Factors, Molecular Epidemiology, and Antibiotic Resistance.

This research sought to determine the prevalence and risk factors of intestinal carriage of extended-spectrum u03b2-lactamases, Enterobacterales, and plasmid-mediated AmpC u03b2-lactamase-producing Enterobacterales in healthy children in Ardabil, Iran, which was the primary source of intestinal contamination of extending-spectrum u03b2-lactamase-producing Enterobacterales. Escherichia coli was the most common ESBL-producing bacterium isolated in ESBL-PE colonized individuals. The most common type of Beyond ESBL positive isolates, bla CTX-M group genes were the most common type, and bla TEM were in the second position. Among bla CTX-M genes, bla CTX-M-1, and bla CTX-M-15 were the most common forms with equal distribution. Both the bla CIT and bla DHA genes in AmpC type enzyme encoding genes were found in AmpC-PE isolates, which were similar AmpC type enzyme encoding genes. Overall, 62% and 59. 5% of isolates were resistant to co-trimoxazole and tetracycline, respectively, despite u03b2-lactam antibiotics. The majority of ESBL-producing E. coli isolate isolates were identified as phylogroup A. Healthy people in Iran had a high incidence of multi-resistant ESBL-PE intestinal carriage, according to this analysis.

Source link: https://doi.org/10.1089/mdr.2021.0029


Network Structure of Autism Spectrum Disorder Behaviors and Its Evolution in Preschool Children: Insights from a New Longitudinal Network Analysis Method.

In the definition of Autism Spectrum Disorder, network mapping of the social, communication, and limiting/repetitive behaviors was carried out by the network. The Autism Diagnostic Interview: Revised assessed behaviors in 139 preschool cases at two separate cross-sections with averaged 34. 8 months apart, 139 pre-school cases. RRB items/nodes developed a cohesive peripheral cluster at both stages, while social and communication nodes developed a core group that changed with time.

Source link: https://doi.org/10.1007/s10803-022-05723-8


Prevalence of autism spectrum disorder diagnosis by birth weight, gestational age, and size for gestational age: a systematic review, meta-analysis, and meta-regression.

Our aim was to significantly pool the prevalence of autism spectrum disorder diagnosis by birth weight, gestational age, and gestational age. ASD prevalence estimates include: very low-birth weight, 3. 6 percent; low-birth weight, 2. 3 percent; normal-birth weight, 2. 3 percent; high-for-gestational-age, 5. 6 percent; and large-for-gestational-age, 0. 6 percent. The prevalence of ASD diagnosis in extremely low-birth weight, low-birth weight, extremely preterm, and small-for-gestational age individuals increased sharply, relative to the reference period, while those in high-birth weight, postterm, and large-for-gestational-age individuals did not change much, compared to the reference prevalence.

Source link: https://doi.org/10.1007/s00787-022-02078-4


A real-world study of interleukin-6 receptor blockade in patients with neuromyelitis optica spectrum disorder.

Between October 2017 and January 2022, we enrolled 65 patients in NMOSD who received daily intravenous administration of tocilizumab between October 2017 and 2022. During tocilizumab therapy, 23% of patients returned to hospital, but the median ARR fell from 1. 9 to 0. 1, with a baseline plasma GFAP level of > 220 pg/mL being risk factors for future relapses. Tocilizumab therapy significantly reduced the relapse rate in patients with NMOSD. However, prolonged infusion times and elevated baseline plasma GFAP levels may raise the risk of relapse risk during tocilizumab therapy.

Source link: https://doi.org/10.1007/s00415-022-11364-9

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions