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Plants treated with Burkholderia sp isolate SSG isolate SSG for one week or longer before being confronted with pathogens that are moderately resistant to a broad variety of pathogens. Besides a pathogen suppressor and plant growth promoter previously mentioned, the data shows that SSG is an ISR inducer conferring plant protection on pathogen encounters.
Source link: https://www.ncbi.nlm.nih.gov/bioproject/796315
The key host antiviral defense in insects is RNA interference, but less is known about how to use antiviral RNAi in fighting viral infection in insects. In cultured Drosophila cells, we found that enoxacin effectively stopped viral replication of Drosophila C virus and Cricket paralysis virus. Our results showed that enoxacin can increase RNAi in insects, as well as raising RNAi in insects, and that enoxacin can be used as a broad-spectrum antiviral agent to reduce mosquito transmission of arboviruses or viral diseases in insect farming.
Source link: https://www.ncbi.nlm.nih.gov/bioproject/781957
Osteogenesis imperfecta is a rare inherited connective tissue dysplasia characterized by mutations in the genes COL1A1 or COL1A2 that code the chains of type I collagen. The majority of which are of southern China origins, are of southern China origins, and in the present study, clinical manifestations and genetic variations were analyzed from 188 Chinese OI patients. Both 64 and 58 OI patients were discovered carrying mutations in COL1A1 and COL1A2, as well as 12 novel COL1A1 and 8 novel COL1A2 variants, with 12 new COL1A1 and 8 novel COL1A2 variants being identified by targeted sequencing, including 12 novel COL1A1 and 8 novel COL1A2 variants. Our results extend the genetic range of type I collagen genes and the genotype-phenotype correlation in Chinese OI patients. The study of safe BP treatment in an age-specific manner may help to improve OI patient management. Overall design: We conducted bulk transcriptomic profiling on osteoblasts obtained from 6 OI individuals with Collagen 1 mutations and two non-OI samples.
Source link: https://www.ncbi.nlm.nih.gov/bioproject/772724
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