Soft Tissue Sarcoma - Springer Nature

Head-to-head evaluation of [^18F]FDG and [^68 Ga]Ga-DOTA-FAPI-04 PET/CT in recurrent soft tissue sarcoma

Compared to [18F]FDG PET/CT, we tested the effectiveness of [68 Ga]Ga-DOTA-FAPI-04 PET/CT for the diagnosis of recurrent soft tissue sarcoma. Methods An overall study of 45 patients with 13 subtypes of STS [18F]FDG and [68 Ga]Ga-DOTA-FAPI-04 PET/CT exam within a week was done, whether local relapse or distant metastasis was found within 1 week. The McNemar test was used to compare the semi-quantitative results of [18F]FDG and [68 Ga]Ga-DOTA-FAPI-04 in tumor lesions, and the McNemar test was used to measure differences between both tracers. In liposarcoma, malignant solitary fibrous tumor sarcoma, and interdigitating dendritic cell sarcoma, [68 Ga]Ga-DOTA-FAPI-04 reported higher values of SUV_max and TBR in liposarcoma, a significantly higher dose of TBR in liposarcoma, a rare solitary fibrous tumor, and interdigitated dendritic cell sarcoma [68 Ga]Ga-DOTA-FAPI-04 PET/CT is a promising new imaging technology for recurrent surveillance of STS, and it ranks favorably with [18F]FDG for finding recurrent lesions of liposarcoma, MSFT, and IDCS. ".

Source link: https://doi.org/10.1007/s00259-022-05700-4

Effect of negative pressure wound therapy after surgical removal of deep-seated high-malignant soft tissue sarcomas of the extremities and trunk wall—study protocol for a randomized controlled trial

"Indicated that negative pressure wound therapy reduced the risk of postoperative wound complications in patients treated with postoperative radiation and surgical tumor removal of lower extremity soft tissue sarcomas, and the use of NPWT was not related to an elevated risk of local recurrence. ".

Source link: https://doi.org/10.1186/s13063-022-06468-6

Diagnostic performance of MRI in detecting locally recurrent soft tissue sarcoma: systematic review and meta-analysis

"Objective" is a term used to describe quantitative and clinical results of MRI in detecting locally recurrent soft tissue sarcoma. Methods Medline and Embase were both looking for original studies on MRI's diagnostic results for local recurrent soft tissue sarcoma. In 2 studies, there was a significant risk of bias with respect to patient selection, as well as a high risk of bias with respect to flow and timing in eight studies. Low signal mass on the apparent diffusion coefficient map gave a pooled sensitivity of 67. 5% and a pooled specificity of 95. 3%. Early and fast arterial phase augmentation at a dynamic contrast-enhanced MRI yielded a pooled sensitivity of 91. 3% and a pooled specificity of 84. 7%. U2022: The presence of a mass on MRI appears to be a good way to diagnose locally recurrent soft tissue sarcoma, because both sensitivity and specificity are high. ".

Source link: https://doi.org/10.1007/s00330-021-08457-w

Pretreatment tumor sampling and prognostic factors in patients with soft-tissue sarcoma of the head and neck

"Methods This retrospective cohort study consisted of 63 patients with STSHN treated at the Helsinki University Hospital between 2005 and 2017. " We investigated the effects of pretreatment tumor sampling on surgical margin status and need for supplemental surgery, as well as prognostic factors and longevity. Primary surgery at a non-academic center was associated with the need for additional surgery. Reduced DSS was attributed to increased tumor quality and primary tumor size over 5 cm. The decision-making between needle biopsy, open biopsy, or upfront radical surgery is based on tumor location and size.

Source link: https://doi.org/10.1007/s00405-021-07162-0

The clinical significance of perioperative inflammatory index as a prognostic factor for patients with retroperitoneal soft tissue sarcoma

"This report examined the inflammatory indices in primary STS with varying preoperative clinical conditions and inflammatory indices, with a particular focus on the transition of inflammatory indices before and after tumor resection in de-differentiated liposarcoma. " Methods The clinical findings of 113 patients with primary retroperitoneal STS undergoing tumor resection were reviewed. Patients with preoperative low CLR who were normalized in DD-LPD had a good survival rate in DD-LPD, with preoperative high CLR and postoperative CLR normalized. Conclusions Elevated CLR before surgery, as well as DD-LPS, were poor prognostic indicators for overall survival in primary retroperitoneal STS. ".

Source link: https://doi.org/10.1007/s10147-022-02150-8

Frailty in Very Elderly Patients is Not Associated with Adverse Surgical or Oncological Outcomes in Extremity Surgery for Soft Tissue Sarcoma

"Background" says that although surgery is the keystay of leg sarcoma therapy, "old age" is a relative predictor of oncological surgery. Patients > 80 years ago were presented with primary extremity soft-tissue sarcoma from 2007 to 2016 and were retrospectively reviewed. Conclusions A total of 141 primary tumors were identified, with 116 of them undergoing resections. Radiology treated 44. 7 percent of patients, with radiotherapy affecting 56. 7 percent. The Median hospital stay was 7 days, with frailty and ASA not related with persistent admission. Except one who died as a result of their disease, all patients with reported DR. Adjusted LRFS and DMFS showed no significant difference in adjusted LRFS and DMFS. According to 87. 0% and 62. 3%, respectively, against 27. 4% and 47. 4%. Conclusions "Extreme surgery for sarcoma is well tolerated in the frail elderly population with low morbidity and similar oncologic findings," the author states.

Source link: https://doi.org/10.1245/s10434-021-11292-4

Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort

"In a trial of patients with soft-tissue sarcomas, clinical outcome measures following anti-PD-1 therapy were more effective in a cohort prospectively selected for the presence of intratumoral lymphoid structures in this cohort than in other cohorts where the majority patients did not have these structures. " In patients with acute soft-tissue sarcomas, immunoe checkpoint inhibitors show limited clinical relevance. According to a retrospective review, intratumoral tertiary lymphoid structures are associated with improved outcomes in these patients. PEMBROSARC is a multicohort phase 2 investigation into peguolizumab and low-dose cyclophosphamide in patients with advanced STs. The 6-month NPR and ORRs for cohorts in this trial, which included all comers, were previously announced; here, we present the findings of a cohort enrolling patients selected based on the presence of TLSs. These findings indicate that TLS presence in advanced STS is a potential predictive biomarker to help patients understand pembrolizumab therapy.

Source link: https://doi.org/10.1038/s41591-022-01821-3

Systemic Treatment of Soft Tissue Sarcomas in the Geriatric Population

"As the population increases, the incidence and prevalence of soft tissue sarcoma in the geriatric population will rise. " This report examines the current state of study into older adults with advanced or metastatic soft tissue sarcoma, undermining the absence of representation of this patient population in clinical trials. Given that chronological age does not necessarily correspond to physiologic age, integration of comprehensive geriatric and quality of life assessments is needed in the care of geriatric patients to help guide therapeutic decisions. ".

Source link: https://doi.org/10.1007/s11864-022-00972-2

Efficacy and Safety of Radioactive ^125I Seed Implantation for Patients with Oligo-Recurrence Soft Tissue Sarcomas

Following surgical reconstruction, osteodine-125 seed implantation for oligo-recurrence soft tissue sarcomas was found by a microscope-guided iodine-125 seed implantation for oligo-recurrence soft tissue sarcomas. Patients with oligorecurrence soft tissue sarcomas following curative surgical resection between June 2013 and December 2020 were included in this article. Materials and Methods According to the Response Evaluation Criteria in Solid Tumors, the primary outcome measure was objective response rate. The study included twenty-nine patients who underwent computed tomography-guided 125I seed transplantation. After surgical resection, 125I seed implantation has the promise to be an efficient and safe treatment for oligo-recurrence soft tissue sarcomas.

Source link: https://doi.org/10.1007/s00270-022-03077-3

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