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Sleep apnoea - PubMed

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Last Updated: 24 April 2022

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Paraoxonase-1 Concentrations in Obstructive Sleep Apnoea: A Systematic Review and Meta-Analysis.

Overproduction of reactive oxygen species and oxidative stress is characteristic of obstructive sleep apnoea. The antioxidant enzyme paraoxonase-1 may be useful in monitoring the antioxidant defense mechanisms and the effects of medications in OSA patients. PON-1 serum concentrations in OSA patients and non-OSA controls were investigated by systematic review and meta-analysis. The meta-analysis included eleven studies in 429 OSA patients and 258 non-OSA controls. In OSA patients, more research is needed to determine the clinical use of PON-1 measurements for risk stratification and monitoring.

Source link: https://doi.org/10.3390/antiox11040766


Postoperative outcomes in surgical patients with obstructive sleep apnoea diagnosed by sleep studies: a meta-analysis and trial sequential analysis.

Identifying surgical patients with obstructive sleep apnoea may be able to minimize postoperative complications. We investigated the effect of obstructive sleep apnoea diagnosed by polysomnography or home sleep apnoea testing on surgical patients' postoperative outcomes using trial-sequent methods. The Mantel-Haenszel method random-effects system evaluated the pooled odds ratios of postoperative complications. Patients were included in twenty prospective cohort studies, with 3756 patients enrolled. Or 1. 61 p. 0. 01; certainty of evidence, moderate; and hospital and ICU re-admission, OR 2. 01; certainty of evidence, low; and medical aid apnoea, OR 1. 61; certainty of evidence, moderate; and cardiac risks, 1. 5 times; or 1. 61, p = 0. 001; certainty of data, low; and physician and ICU re-admission, OR 2. 01; certainty of findings, low; certainty of patients, a Patients in whom obstructive sleep apnoea had been recently diagnosed were particularly at risk, highlighting the importance of pre-operative screening.

Source link: https://doi.org/10.1111/anae.15718

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions