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The relationship between OSA and cardiovascular disease can be explained, at least in part, by coexistence of cardiovascular risk factors in the two pathologies, including age, obesity, smoking, and sedentary lifestyle. The use of continuous positive airway pressure therapy in primary and secondary cardiovascular prevention has not shown a significant decrease in the incidence or recurrence of cardiovascular disease. This paper explores the relationship between OSA and cardiovascular risk and cardiovascular disease, as well as recent research addressing the safety of CPAP in primary and secondary cardiovascular prevention.
Source link: https://doi.org/10.15420/ecr.2020.10
The antioxidant enzyme paraoxonase-1 may be useful in determining the antioxidant defense mechanisms and the effects of medications in OSA patients. PON-1 serum concentrations in OSA patients and non-OSA controls were investigated, by way of systematic review and meta-analysis. The meta-analysis included 11 studies in 429 OSA patients and 258 non-OSA controls. In OSA, the pooled serum PON-1 concentrations were significantly lower. PON-1 findings for risk stratification and monitoring in OSA patients are still needs to be determined by clinical studies.
Source link: https://doi.org/10.3390/antiox11040766
Paediatric patients with temporomandibular joint ankylosis, mandibular retrognathia, and obstructive sleep apnoea are all difficult. The patient underwent mandibular sedation and, later, the introduction of the TMJ ankylosis and rib graft reconstruction.
Source link: https://doi.org/10.18295/squmj.2018.18.03.019
Peripheral arterial disease causes severe atherosclerosis with a high mortality. Patients with persistent PAD in Fontaine's stages IIb, III, and IV were admitted to Fontaine clinical stage IIb, III, and IV, respectively, and were principally treated for femoropopliteal occlusive disease. Mean apnoea index and mean oxygen desaturation index were 28. 2 19. 5/h and 26. 7 18. 8 percent, respectively, among those patients with polygraphically reported sleep apnoea. Sleep apnoea was frequent and obstructive sleep apnoea in PAD's severity stages, according to PAD severity ratings. Long-term results regarding the effect of CPAP therapy on the PAD course remain to be determined.
Source link: https://doi.org/10.1371/journal.pone.0181733
The goal of this study is to determine the underlying leptin levels in OSA patients and its potential relationship to OSA risk, independent of confounders and evaluate the Autoadjusting-CPAP effect on leptin values. Methods In ninety eight male patients with moderate to acute OSA leptin serum levels were analyzed before therapy, 9 days and six months after therapy. A significant correlation was observed between serum leptin values and BMI, waist-hip ratio, and AHI in stepwise multiple regression analysis; only BMI was a predictor of serum leptin values in stepwise multiple regression analysis.
Source link: https://doi.org/10.1186/1471-2466-8-21
For 35% of anesthesia-related deaths and OSA patients, there is a higher risk of difficult intubation. The aim of the study was to determine the presence and comparability of OSA screening methods in predicting difficult mask ventilation and DIT in patients with undiagnosed OSA. Methods: In a tertiary care center in patients undergoing elective surgery, a prospective observational research was conducted. Results: In this case, a total of 54 patients in OSA and 46 patients in a non-OSA cohort were tested. While history of apnea, body mass index > 35, and sleep apnoea clinical score > 35 had the most preciseness in determining the occurrence of difficult airway, the history of snoring had the highest sensitivity and negative predictive value. According to the single most reliable predictor of DMV, the most significant predictor of DMV was a STOP-BANG score. Conclusion: Positive screening results for OSA have been attributed to difficult airway control, which is the case with poor airway control.
Source link: https://doi.org/10.4103/ija.IJA_158_18
Introduction The prevalence of obesity is steadily increasing around the world, contributing to the occurrence of obesity hypoventilation syndrome and its related mortality. Methods We reviewed the treatment regimen, comorbidity, and mortality of all OHS patients treated at our hospital between 2005 and 2016. The control group was made up of random patients with obstructive sleep apnoea treated during the same period. Study of 206 OHS patients and 236 OSA patients. The OHS patients had more hypertension and diabetes than the OSA ones, but there were no rises in stroke or ischaemic heart disease incidences. The 5- and 10-year, unadjusted survival rates among the OHS patients were lower than those of the OSA patients. After accounting for covariates, the mortality rate in both OHS and OSA patients decreased significantly both in OHS and OSA patients. Conclusions And after adjusting for covariates, the mortality rate in OHS was significantly higher than that in OSA patients.
Source link: https://doi.org/10.1183/23120541.00101-2019
Background: Obstructive sleep apnoea and polycystic ovary syndrome are both associated with significant comorbidities and commonly coexist. The primary aim of this investigation was to investigate the link between OSA and quality of life in women with PCOS. Women with normal ESS and low-risk Berlin questionnaire, or women with normal sleep tests [oxygen desaturation index 5 events/hour]; and PCOS+OSA: women with PCOS and OSA ODI 5. Using the World Health Organization QoL questionnaire and the PCOS health-related quality of life questionnaire, QoL was assessed. Compared to women with PCOS only, women with PCOS+OSA had higher BMI, HbA1c, C-reactive protein, and low-density lipoprotein. Conclusions: OSA is highly common, and it is correlated with decreased QoL and a poor metabolic profile in women with PCOS. Interventional studies are needed to investigate the effect of OSA in women with PCOS.
Source link: https://doi.org/10.1177/2042018820906689
The key intermediary mechanisms associated with sleep apnoea and intermittent hypoxia have been demonstrated as sympathetic stimulation, oxidative stress, and systemic inflammation. As far as coronary heart disease, arrhythmias, and heart failure, whether treating sleep apnoea results in persistent cardiovascular disease is not fully understood. Central sleep apnoea mainly appears as a result of heart failure in this late condition, with obstructive sleep apnoea as a risk factor for heart failure in this late period, while central sleep apnoea primarily appears as a result of heart failure. Many randomised controlled trials have found that treating sleep apnoea may cause heart failure morbidity and mortality.
Source link: https://doi.org/10.1183/09059180.00004513
From a randomly chosen group of OSA patients, 1,327 met inclusion criteria. A large-sample survey was set to be carried out to determine depressive status and other risk factors in Chinese patients with OSA. Patients were enrolled into OSA without depressive status and OSA with depressive status groups after undergoing screening with the Symptom Checklist 90 and Self-Rating Depression Scale. Using Mann-Whitney U. The prevalence of depression in OSA patients was 44%. Besides, the PSSS and scores for its two sub-factors were all lower in Chinese OSA patients with depressive status, which was also linked to single status, apnoea index, hypoxemia, family, and social services, according to investigators.
Source link: https://doi.org/10.1371/journal.pone.0149939
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