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Sleep apnoea - ClinicalTrials.gov

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Last Updated: 24 April 2022

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Obstructive Sleep Apnea and Glucose Metabolism

Obstructive sleep apnea, which disrupts sleep and makes it impossible to breathe during the night, affects sleep. The investigators will do this by comparing glucose levels in people with OSA and those who do not have OSA, as well as determining the consequences of treating OSA by providing continuous positive airway pressure or simply oxygen throughout the night. Knowing the root cause of Obstructive Sleep Apnea and pathophysiologic abnormalities associated with OSA-related metabolic abnormalities may help create potentially new therapeutic approaches for adults in reducing OSA and related comorbidities.

Source link: https://clinicaltrials.gov/ct2/show/NCT03408613


Central Sleep Apnea Treated by CO2 Supplied by a Novel Device

During the overnight study, the aim was to determine if the device could improve sleep quality while also reducing CSA. Patients with central sleep apnea diagnosed by diaphragm EMG will be included in this study. On the third night, patients were then treated with an effective lowest concentration of CO2 derived from titration under PSG.

Source link: https://clinicaltrials.gov/ct2/show/NCT04907058


Improving Sleep Apnea Treatment Adherence After Brain Injury: A Feasibility Study

Alternatives to traditional education, such as Motivational Interviewing and Cognitive Behavioral Therapy, have been shown to increase PAP adherence in persons without brain injury. No published studies have investigated the effectiveness of frontline PAP therapy for people with brain injury. To maximize PAP success in Veterans with OSA and TBI-related burden, this report is designed to develop and evaluate the possibility of a manualized intervention derived from evidence-based MI and CBT and enhanced with cognitive accommodations. The following inclusion criteria for this study are as follows: moderate-to-severe TBI; diagnosed with OSA and PAP therapy; are nonadherent to PAP therapy; and are willing to participate. Two independent evaluators will listen to 20% of audio-recorded sessions and conduct intervention fidelity checks using a Fidelity Rating Checklist developed for this purpose by the PI and modified from other rating MI and CBT fidelity tools. Participants will be contacted within 15 business days following their last intervention session for the qualitative interview to gather evidence on the intervention's acceptability. During study pre-screening and 30 days after the last intervention session, the project manager/research assistant would download objective PAP compliance data from the PAP software package during study pre-screening and reporting compliance to enable evaluation of compliance. The qualitative team will independently read the data, assign codes and codes to data segments, and produce initial themes, then meet to establish consensus on initial themes and codes, revising them using an iterative approach, confirming findings and considering competing explanations that contrast with conclusions and conclusions.

Source link: https://clinicaltrials.gov/ct2/show/NCT04221009


SLEEP APNEA SYNDROME AND TRISOMY 21 : Exploration of the Predictive Factors in the Population With Trisomy 21

The predictive factors for OSA will be investigated are: physical fitness level, dentofacial disharmonies, blood chemistry, motor impairment, motor disabilities, heart rate variability, and autonomic nervous stimulation by orthostatic stimulation by orthostatic test. Is OSAS predicted by an insufficient amount of physical activity?

Source link: https://clinicaltrials.gov/ct2/show/NCT03445962


Mechanisms of Prediabetic States in Sleep Apnea

Understanding how obstructive sleep apnea affects glucose metabolism may help identify new risks for risk prediction and/or treatment of metabolic impairments that do not have continuous positive airway pressure. Obstructive sleep apnea patients with prediabetes will be tested under three in-laboratory conditions in a random cross-over scheme: untreated condition, treated condition, untreated, but drugcologically suppressed lipolysis disease, according to a randomized cross-over scheme.

Source link: https://clinicaltrials.gov/ct2/show/NCT04234217


Prevalence of Sleep Apnea in Patients Undergoing Surgery for Colorectal Cancer

Inclusion: 200 patients with colorectal cancer will be investigated before surgery, and 100 of them will also be investigated in the same manner after surgery. Men and women from two national cohort studies; "Sleep and health in Women" and "Men in Uppsala: A Study of Sleep, Apnea, and Cardiometabolic Health" and older men and women from a local senior group.

Source link: https://clinicaltrials.gov/ct2/show/NCT02323464


Sleep Apnea in Heart Failure With Preserved Ejection Fraction - Exercise Capacity and Impact of Positive Airway Pressure Therapy

The prevalence of OSA in all HFpEF patients at baseline using home sleep apnea testing will be determined, and all patients will complete the Mayo Sleep Questionnaire. Patients with known OSA at baseline will also be included in the baseline analysis to help determine the prevalence of OSA in gold-standard diagnosed HFpEF.

Source link: https://clinicaltrials.gov/ct2/show/NCT05008432


Obstructive Sleep Apnea in Patients With Long COVID-19 Fatigue: a Multicentre Prospective Cohort Study

The most common post-COVID-19 symptom is fatigue, which is similar to myalgic encephalomyelitis/chronic fatigue syndrome, which has also been present in other viral infections. Patients in the post-CoVID-19 Out Patients Hospital Clinics will be able to determine the prevalence of OSA and its association with post-COVID-19 fatigue, which remains for at least six months after the acute disease. Demographic, clinical, and clinical research forms will be collected between the 6-7th month after COVID-19's diagnosis and 9 months later. ESS will be used to determine OSA-related daytime sleepiness. Between the 6-7th month after the diagnosis of COVID-19, the OSA diagnosis will be made using a portable monitoring device model III.

Source link: https://clinicaltrials.gov/ct2/show/NCT05290350


Diagnosis and Treatment of Sleep Apnea in Women Veterans

Positive airway pressure therapy is the recommended first-line therapy for those patients with SDB. According to published reports, women have lower PAP adherence than men, particularly in the United States, yet the investigators are unaware of data comparing men and women Veterans. Since women Veterans suffer with significant sleep disturbance and other effects of sleep disorders, adapting to PAP therapy may be difficult. This is a randomized controlled trial that seeks to determine the efficiency of a program that integrates patient education with behavioral techniques in order to increase adherence to PAP therapy. This is a randomized controlled trial that has been carried out. Women Veterans 18 years and older, those who have received medical attention at the VA Greater Los Angeles Health Department, and who have at least one risk factor for SDB will be recruited for this research. Three months after PAP was introduced, main study findings will be published, and PAP adherence will be monitored remotely for 12 months.

Source link: https://clinicaltrials.gov/ct2/show/NCT03377452

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions