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Obstructive sleep apnea is very common and has numerous effects. One limitation is the lack of simple and validated approaches for OSA diagnosis at home. This work was designed to establish a wireless high-resolution oximeter with a built-in accelerometer linked to a smartphone with automated cloud analysis, which was compared to a home sleep test conducted on the same night. Out of a task force of 1013 patients with suspected OSA who were referred to our center for diagnosis, we recruited 670 patients. For two nights in a row, 62 patients underwent HST to determine the night-to-night OSA severity variation.
Source link: https://doi.org/10.1038/s41598-022-17698-8
We wanted to know whether l arginine/NO metabolism differs between adults with or without comorbid OSA, as well as asthma morbidity, according to a study by asthma morbidity. Patients with asthma and OSA had significantly higher serum traces of NO synthase inhibitor asymmetric dimethylarginine, lower L-arginine to ornithine ratios, and elevated ornithine and proline levels relative to those without OSA. After adjusting for key covariates such as body mass index and L-arginine metabolites, adjusted means difference in adjusted models: 0. 53 versus 0. 53. Adults with asthma and OSA had elevated ADMA, an inhibitor of nitric oxide synthase, and greater metabolism of l arginine via the arginase pathway in comparison to those with asthma alone, suggesting a potential shared pathophysiological mechanism of these disorders.
Source link: https://doi.org/10.1186/s12931-022-02157-9
Purpose The coexistence of obstructive sleep apnea and chronic obstructive pulmonary disease has been described as a 'u201coverlap syndrome', a multisymptomatic pulmonary disease. u201d Patients with OSA are usually older than those with OSA alone, and they suffer from more advanced oxygen dehydration during the obstructive events often associated with persistent nocturnal hypoventilation. As a potential alternative to PAP in patients with OS, the aim of this study was to determine the effectiveness of nocturnal oxygen therapy by nasal high flow. When compared to baseline and COT, NHF-OT significantly decreased the apnea-u2013hypopnea index in all patients.
Source link: https://doi.org/10.1007/s11325-022-02702-2
Introduction Solriamfetol, a dopamine/norephrine reuptake inhibitor, has been approved to treat adult sleepiness with obstructive sleep apnea. Solriamfetol's initiation is limited in real-world study. Methods This descriptive research, which included a quantitative retrospective patient chart review and a hypothetical patient scenario, enrolled US-based physicians prescribing solriamfetol for EDS related to OSA and/or narcolepsy, found in this descriptive research. Most patients had severe OSA and 92% were adherent to positive airway pressure therapy, according to a Mean apnea index at diagnosis. Physicians discontinuing prior WPAs were asked about the current dose and potential adverse events in a hypothetical patient scenario. At data processing, the majority of patients were stable on solriamfetol. Conclusions And Conclusions In a real-world review, most physicians began solriamfetol at 37. 5 or 75 mg/day and titrated to 75 or 150 mg/day for patients with OSA, increased dosages a bit, and abruptly stopped prior WPAs.
Source link: https://doi.org/10.1007/s12325-022-02249-4
Sleep apnea automatically from a simple, portable device is a need in general medicine and critical care. Using a large database serving as ground truth, the aim was to detect abnormal respiration and calculate the Apnea Index automatically with a wearable respiratory unit with and without SpO_2 signals. Two models were tested, one each using the respiratory functions only, a SpO_2 -signal only, and two other models that use the respiratory functions and the SpO_2 module, with one allowing a time lag of 30 seconds between the two signals. Conclusions A wearable respiratory effort signal with or without SpO_2 signal predicted AHI accurately, and best results were obtained by using both signals.
Source link: https://doi.org/10.1007/s11325-021-02465-2
Objectives of study This report established the connection between obstructive sleep apnea and hypopnea, determined by a 3% O_2 desaturation or arousal, but not by a hypopnea criterion of u2265 4% and subjective sleepiness. Methods The study was analyzed by Sleep Heart Health Study participants who had polysomnography regarding OSA and subjective sleepiness ratings. In 3%A only OSA cases only, the ESS rating was higher than in those without OSA. The ESS score was higher in those with 3% only OSA than those with no OSA. The ESS was the result of a 3% only AHI relationship with the ESS. However, 23. 3% of the participants with hypersomnia did not qualify as OSA if arousals were excluded from the definition of OSA. Conclusions The latest report found that the presence and severity of OSA is correlated with higher ESS scores in individuals with 3%A only OSA.
Source link: https://doi.org/10.1007/s11325-021-02494-x
Objective The aim of the study was to establish a multiparametric oximetry scale to distinguish obstructive sleep apnea in adults. In the sleep laboratory, we included adults who had undergone a diagnostic polysomnography with few artifacts and a total sleep time of at least 180 minutes. Apnea-hypopnea index u2265 5 is a determinant sleep apnea. Depending on moving windows from 5 to 60 min, the program measured several variables of oxygen saturation variation – oxygen saturation index and 90, 95, and 97. 5 percentiles of both the number of oxygen desaturations : desaturation index and 90, 95, and 97. 5 percentiles. The IMp-SpO2 test group's experimental unit used a combination of ten physical parameters of oxygen saturation variation in a series of ten variables. OSA showed that at least one IMp-SpO2 variable had a good diagnostic result. Conclusion The IMp-SpO2 test performed with a > 90% rate for OSA diagnosis in adults.
Source link: https://doi.org/10.1007/s11325-021-02439-4
In patients with acromegaly, the aim is to determine the occurrence of obstructive sleep apnea and the correlation between the adenoma granulation patterns and OSA. Contrasted with the non-OSA group, OSA patients had a larger share of the densely granulated pattern. The OSA groups with DG acromegaly had a smaller maximum tumor diameter and Vol/2 than those with the sparsely granular pattern. In addition, a higher growth hormone level and GH index were discovered in DG acromegaly patients with severe OSA. In addition, there was a trend toward more standardized insulin-like growth factor 1 in patients with DG acromegaly than in those with SG acromegaly in the severe OSA group. Conclusions The results show that OSA is a common disease in patients with acromegaly, and that the DG pattern may be a risk factor for OSA in acromegaly.
Source link: https://doi.org/10.1007/s11325-021-02468-z
Purpose: The comorbidity of periodic limb movements during sleep in sleep-ordered breathing remains uncertain, according to the author's study. In people with obstructive sleep apnea, this research sought to determine whether or not the presence of PLMS is related to depression and poor quality of life. Multiple logistic or linear regression analyses were used to determine multiple logistic or linear regression models for the Medical Outcomes Study Short Form Health Survey and Beck Depression Inventory. Severe OSA was less likely to be associated with PLMS than with mild OSA. PLMS negatively correlated with physical and mental component summary scores of the health survey, but not with Beck Depression Inventory results after accounting for confounding variables. Conclusions Health-related quality of life, including physical and mental stability, but not depressive symptoms, was worse in students with OSA and PLMS than in those without PLMS.
Source link: https://doi.org/10.1007/s11325-021-02469-y
Methods Sprague u2013Dawley rats were in a normoxic control group, or rats were in a continuous nocturnal intermittent hypoxia group, or rats were in a chronic nocturnal intermittent hypoxia group pretreated with ARB. In the sleep apnea model associated with JNK de-activation and SIRT1 upregulation, the ARB may prevent cardiac FasL to mitochondrial apoptotic pathways and promote cardiac IGF1/PI3K/AKT pro-survival pathway and improve cardiac IGF1/PI3K/AKT pro-survival pathway and improve cardiac IGF1/PI3K/AKT pro-survival pathway.
Source link: https://doi.org/10.1007/s11325-021-02499-6
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