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Objectives: Obstructive sleep apnea is believed to be a source of secondary polycythemia. The present review reviewed the literature examining secondary polycythemia in patients with OSA and identified the effects of continuous positive airway pressure therapy on hemoglobin and hematocrit levels in patients with OSA. Methods We searched MEDLINE, Embase, and Cochrane for studies of adult patients with OSA who showed hemoglobin and/or hematocrit values. In the pooled analysis of ten single-arm trials involving 434 patients, CPAP therapy reduced hemoglobin by 3. 76 g/L. Similarly, a randomized review of ten single-arm trials involving 356 patients without baseline polycythemia showed that CPAP treatment reduced hematocrit by 1. 1%. Both the hemoglobin and hematocrit decreases in contrast to severe OSACPAP treatment for OSA, according to Pooled's report, OSA is linked to an elevated risk of secondary polycythemia.
Source link: https://europepmc.org/article/MED/35962574
Methods Pooled study was conducted to compare CRP and TNF-u03b1 levels among OSA patients with different severity and controls, as well as between continuous positive airway pressure and non-CPAP treatments for OSA patients. We estimated the causal correlations between CRP and TNF-u03b1 levels and OSA risk using published GWAS summary data. Both TNF-u03b1 and CRP increased in OSA patients in comparison to controls, and this trend was correlated with OSA severity. Moreover, IVW's initial MR report found that OSA was the genetically predicted cause of elevated CRP using six SNPs as the instrument variable, which were repeated by weighted median and MR RAPS. Moreover, the causal effect of elevated CRP on elevated OSA risk was almost non-significant by IVW.
Source link: https://europepmc.org/article/MED/35652886
Obstructive sleep apnea can exacerbate subarachnoid hemorrhage's prognosis. We developed a subarachnoid hemorrhage mouse model by using the endovascular permeation technique, and then exposed the mice to intermittent hypoxia for 8 hours a day for two days in this research to mimic sleep apnea. In this mouse model of subarachnoid hemorrhage, sleep apnea aggravated brain edema, increased hippocampal neuron apoptosis, and worsened neurological function. We further investigated the underlying mechanism and discovered that sleep apnea, interleukin-1, interleukin-6, pro-caspase-1, and NLRP3, promoted astrocyte formation, and raised the expression of hypoxia-inducible factor 1b1 and a CARD-like protein containing a CARD signaling pathway.
Source link: https://europepmc.org/article/MED/35535908
The unique pathophysiologic causes of obstructive sleep apnea to pulmonary hypertension and right ventricular dysfunction are still understudied area. The retrospective review and analysis of data of consecutive patients with OSA who underwent right heart catheterization for analysis of pulmonary hemodynamics was retrospectively collected and analyzed. To determine the significant respiratory parameter associated with right heart catheterization measurements, Univariable and multivariable regression studies were used. The time percentage spent with SpO2 below 90 percent was the sole and the most significant independent factor associated with mean pulmonary artery pressure, pulmonary vascular resistance, and RV stroke work index, among other sleep parameters. According to the corresponding risk of PVR > 3 WU, for every 5 units increase in T90, there was about 36% higher risk of mPAPu226525mmHg and a 5 percent higher risk of PVR>3 WU. A review of OSA with hypoxemic duration may aid in the early detection of impaired pulmonary hemodynamics and RV dysfunction in infants.
Source link: https://europepmc.org/article/MED/36081323
Oropharyngeal myofunctional therapy is a multi-component therapy that can reduce the severity of obstructive sleep apnea. To determine the effects of a 6-week tongue elevation training program in patients with OSA. Participants in Eligible participants were adults with moderate OSA who had poor adherence to regular positive airway pressure therapy. With the Iowa Oral Performance Instrument, the intervention group completed a 6-week tongue elevation training program that included anterior tongue strengthening and endurance tasks. The control group undertook a 6-week sham training program that involved expiratory muscle training at a very low level. In the intervention group, daytime sleepiness and tongue endurance were both significantly improved compared to the control group. 75% of participants experienced a decrease in daytime sleepiness that exceeded the minimal clinically significant difference. There were no effects on OSA severity after six weeks of tongue elevation muscle strengthening.
Source link: https://europepmc.org/article/MED/36081312
We quantitatively assessed sleep apnea headache using the Epworth sleepiness scale and headache impact questionnaire -6. Methods The first part of this research included 86 patients who had been diagnosed with OSA by polysomnography in our sleep center and investigated the prevalence and causes of sleep apnea headaches. The second part of the study of headache management with sleep apnea by polysomnography and/or peripheral arterial tonometry determined the effects of OSA therapy on headaches. Results The prevalence of sleep apnea headache among OSA patients was 22. 1% in females but not in males. In patients with headache than in patients without, the female, median apnea-hypopnea index was significantly lower in patients with headache than in patients with headache. Conclusion Among patients with OSA, the risk of sleep apnea headache in females was higher than in males. OA in mild to moderate OSA patients showed dramatic effects on headaches.
Source link: https://europepmc.org/article/PPR/PPR541499
Background of this prospective study The primary aim of this prospective research was to determine the effects of elevated ANGPTL3 on cardiovascular events in patients with or without obstructive sleep apnea. Patients with OSA had elevated ANGPTL3 levels than those without OSA. Patients with ACS with OSA were at a significantly elevated risk of CVEs in patients with OSA but not without OSA. Moreover, adding ANGPTL3 to the Cox model raised C-statistic values by 0. 035 and 0. 029 in the OSA group and all patients with ACS, respectively, but not significantly improved in patients with ACS without OSA, respectively. Conclusions In conclusion, our study reveals a predicting influence of plasma ANGPTL3 on cardiovascular risk in patients with ACS, especially in patients with OSA.
Source link: https://europepmc.org/article/MED/36073641
Obstructive sleep apnea is very common and has numerous repercussions. This study was designed to demonstrate a wireless high-resolution oximeter connected to a smartphone with automated cloud analysis, which was compared to a home sleep test conducted on the same night. 62 patients underwent HST for two nights in a row to determine the night-to-night OSA severity variation. We have concluded that Biologix is a simple and effective method for OSA diagnosis at home.
Source link: https://europepmc.org/article/MED/36071120
Obstructive sleep apnea is a common sleep disorder related to autonomic nervous system disturbances. Patients with obstructive sleep apnea had significantly reduced sympathetic function compared to controls. Patients with persistent obstructive sleep apnea had significantly lower paragly, high-frequency, root mean square, and a greater ratio of low-frequency and high-frequency for the obstructive sleep apnea, according to the obstructive sleep apnea's subgroup meta-analysis, patients with significant interrhythmic function, high-frequency, etc. of the earliest intervals of a However, the ratio of low-frequency to high-frequency was significantly higher in patients with moderate to moderate obstructive sleep apnea than in controls. In patients with severe obstructive sleep apnea, autonomic function impairment was more severe. Low-frequency sleep apnea can well represent autonomic function in obstructive sleep apnea, and the ratio of low-frequency to high-frequency may play a significant role in obstructive sleep apnea diagnosis.
Source link: https://europepmc.org/article/MED/36070876
To summarize and outline key characteristics of clinical care of the OSA adult patient, the OSA adult patient requires a forensic analysis and interpretation of the literature on obstructive sleep apnea. The International Consensus Declaration on Obstructive Sleep Apnea is a compilation of multidisciplinary experts in sleep research and therapy aimed at achieving this end. Results The ICS:OSA addresses OSA syndrome definitions, pathophysiology, epidemiology, risk factors for disease, diagnostic instruments, multiple therapeutic modalities, and the effects of OSA and treatment on multiple comorbidities. Improveing the metrics of OSA disease, determining the most suitable OSA screening protocols, implementing PAP monitoring and longitudinal care, enhancing PAP testing and longitudinal care, determining health risk factors, and translating evidence into individualized approaches to therapy are among the ways that can be improved.
Source link: https://europepmc.org/article/MED/36068685
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