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We wanted to know whether l-arginine/NO metabolism differs between adults with or without comorbid OSA, as well as asthma morbidity. Patients with asthma and OSA had significant serum concentrations of NO synthase inhibitor asymmetric dimethylarginine, lower L-arginine to ornithine ratios, and elevated ornithine and proline levels in comparison to those without OSA. After accounting for key covariates including body mass index and L-arginine metabolites, adjusted mean difference in adjusted models was shown in adjusted models, with worse asthma control, adjusted mean difference in asthma control questionnaire of 0. 36, and asthma quality of life questionnaire, adjusted mean difference: u2212 0. 53. Adults with asthma and OSA had elevated ADMA, an inhibitor of nitric oxide synthase, and increased metabolism of l-arginine through the arginase pathway, compared to those with asthma alone, indicating a possible shared pathophysiological mechanism for these disorders.
Source link: https://doi.org/10.1186/s12931-022-02157-9
Abstract Obstructive sleep apnea is extremely common and has multiple repercussions. Patients with suspected OSA who had been directed to our center for diagnosis were treated to 670 patients out of a task force of 1013 patients with suspected OSA. 62 patients underwent HST for two nights in a row to determine the night-to-night OSA severity variation. We conclude that Biologix is a simple and effective method for OSA diagnosis at home.
Source link: https://doi.org/10.1038/s41598-022-17698-8
Objectivitive and Obstructive objectives in Colombia between 2017 and 2021, to explore the sociodemographic and epidemiological characteristics of pediatric patients with sleep apnea diagnosis and treatment in pediatric patients with sleep apnea, both central and obstructive. Methods Observation of Sleep Studies using the International Classification of Diseases and Related Health Problems (ICHS) as search terms for insomnia, according to a research by SISPRO, Colombian national health registry. Discussion This is the first approximation to a national prevalence of sleep apnea in Colombia, which is lower than what is found in the literature around the world, and it could refer to sub diagnosis and subanalysis. The decrease in incidences in 2020 and 2021 may be due to the COVID-19 pandemic effects on sleep medicine services.
Source link: https://doi.org/10.1371/journal.pone.0273324
Currently, it is estimated that there is a significant underdiagnosis of OSA in the adult population participating in primary care, mainly due to a lack of access to the tests for that purpose. MethodsA descriptive multicenter study was conducted to determine the usefulness of the Spanish version of the STOP-Bang questionnaire for screening for moderate or severe OSA. The findings revealed that 61. 5 percent of the subjects had OSA, with 22. 5 percent a mild OSA. ConclusionsThe SBQ obtained an ROC curve of 0. 669 that had an optimal cutoff of 3. 5 percent and a specificity of 55. 1 percent, which is highly useful for finding moderate/severe OSA screening with a sensitivity of 84 percent and a specificity of 55. 1 percent. The SBQ is a highly useful instrument for primary health care professionals due to its simplicity of use.
Source link: https://doi.org/10.3389/fpubh.2022.975114
Objectives:MethodsQualitative research was conducted in a multi-patient study at the IRCSS Istituto Auxologico San Giuseppe Hospital in Verbania, Italy, with a representative sample of 32 patients with obstructive sleep apnea syndrome and comorbid obesity following continuous positive airway pressure therapy, as well as ongoing disease self-management. Individual counseling services aimed at assisting the individual with the psychological and emotional challenges posed by the use of CPAP, as well as improving self-efficacy and self-management skills are also recommended for optimal treatment during the rehabilitation program.
Source link: https://doi.org/10.3389/fpsyg.2022.947346
In recent years, the prevalence of obstructive sleep apnea has greatly increased. According to recent reports, severe and moderate cases of OSA affect between 6 and 17% of adults in the general population. Several journals are revealing the dramatic rise in the incidence of OSA in patients with fibrotic diseases, including idiopathic pulmonary fibrosis. We focused on the prevalence of OSA among IPF patients due to a lack of papers focusing on IPF among OSA patients. The final analysis was performed on 614 IPF patients from 18 studies that met inclusion criteria. There were 469 IPF patients with OSA and 145 without, as well as 145 without. The median prevalence of OSA among non-IPF patients for all of the ethnic groups included in this survey was 16,4%. When compared to the general OSA prevalence, the study shows strong evidence for the increased incidence of OSA in IPF patients.
Source link: https://doi.org/10.3390/jcm11175008
Aims: To determine the safety and effectiveness of a new approach for transoral tongue suspension in obstructive sleep apnea patients. Methods and Methods: The retrospective analysis included 24 consecutive OSA patients with tongue blockage confirmed by drug-induced sleep endoscopy. TOTS' key steps included a transoral sublabial approach, drilling two holes on the mandible, transferring the polypropylene through the hole to the tongue base, and tying the polypropylene to the mandible. In hypertrophic lingual tonsils, Lingual tonsil ablation was also used. According to the Epworth Sleepiness Scale, the quality of life in the patients' subjective daytime sleepiness improved significantly. Conclusions: With a scary exterior and quick results, the demonstrated TOTS demonstrated its advantage in low morbidity with a scarless exterior and a quick success with free availability in treating adult OSA patients with tongue obstruction. Toto's combined with UPPP has greatly improved AHI and daytime sleepiness.
Source link: https://doi.org/10.3390/jcm11174960
Obstructive sleep apnea is a sleep disorder affecting the upper airway, but it is also associated with numerous systemic diseases. Both groups found an association of both types in eleven of the sixteen studies focusing on the incidence of glaucoma in patients with OSA. In OSA patients, one paper showed a greater risk of glaucoma progression. The influence of OSA therapy on retinal nerve fiber layer thinning and vision was found in one study out of three research identifying specific ophthalmological variables. One study showed a rise in intraocular pressure, while two other studies found no increase under continuous positive airway pressure. Conclusions: Our results point to an association between OSA and glaucoma, as well as between OSA and RNFL thinning. CPAP therapy appears to have been equally appropriate for patients with comorbid glaucoma.
Source link: https://doi.org/10.3390/ijms231710080
A systematic analysis of exercise's impact on OSA is needed with exercise being more commonly used in medical care for obstructive sleep apnea. As for the results of subgroup analysis, aerobic exercise plus resistance exercise [MD = u22124. 36, 95% CI, p = 0. 0002] had a greater effect on AHI reduction than aerobic exercise alone [MD = u22124. 36, 95% CI, p = 0. 0002]. Exercise reduces the risk of OSA with no changes in BMI, according to this systematic review, and aerobic exercise mixed with resistance training is better than aerobic exercise alone in AHI reduction. Exercise also improves cardiopulmonary endurance, sleep quality, and excessive daytime sleepiness.
Source link: https://doi.org/10.3390/ijerph191710845
The current research was conducted to determine the presence and predictors of OSA in patients with type 2 diabetes. Patients with already diagnosed OSA, as well as those who are receiving treatment were excluded from the study. In comparison to the 100 who were not at risk of OSA, 64 of the 164 diabetic patients enrolled in the study were at high risk for OSA. Patients with a high risk of OSA were those with a high risk of OSA with body mass index u226525. Conclusions: OSA has a high incidence in T2DM-affected diabetic patients, which encourages the physicians to remain vigilant for signs and symptoms of OSA in diabetic patients and monitor their compliance in terms of weight control, diet control, and medication use.
Source link: https://doi.org/10.4103/jopcs.jopcs_4_20
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