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Sleep Apnea - ClinicalTrials.gov

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Last Updated: 12 January 2023

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Obesity and Sleep Apnea in Pregnancy

Aim 1: To test the possibility that maternal obesity raises OSA risk, but not to a greater extent in obese women with excessive gestational weight gain vs. obese women with elevated weight gain vs. obese women with excessive weight gain. The study team will use the state-of-the-art microscope to determine resting sympathetic function and sympathetic neural responses to physiological stimulations during early and late pregnancy, and postpartum in obese women with and without OSA and non-obese women without OSA. Aim 3: To see if corin content is higher in obese women than non-obese women during pregnancy, the most common among obese pregnant women with OSA is obese pregnant women. In women enrolled in the AIM 2 project for measurements of serum corin content and pregnancy-specific angiogenic factors such as soluble tyrosine kinase 1, placental growth factor, and soluble endoglin will be collected.

Source link: https://clinicaltrials.gov/ct2/show/NCT05654259


Diagnosis and Treatment of Sleep Apnea in Women Veterans

Positive airway pressure therapy is the most commonly used first-line therapy for the majority of patients with SDB. According to published reports comparing men and women veterans, women have lower PAP adherence than men, particularly in the United States, yet the investigators are unaware of studies comparing men and women Veterans. Because women Veterans suffer from persistent sleep disturbance and other signs of sleep disorders, transitioning to PAP therapy may be difficult. For this report, women veterans 18 years and older, who have received medical attention at the VA Greater Los Angeles Healthcare System, and who have at least 1 risk factor for SDB will be recruited. Using a WatchPAT device, screening for sleep apnea will be carried out in the participant's home. The PAP trial findings will be published three months after PAP's inception, and PAP adherence will be monitored remotely for 12 months.

Source link: https://clinicaltrials.gov/ct2/show/NCT03377452


Pathophysiology-Guided Therapy for Sleep Apnea in the Elderly

Positive airway pressure therapy is deemed cumbersome and is often associated with non-adherence to therapy. Specifically, the investigators will investigate whether interventions with sustained hyperoxia, finasteride, and acetazolamide would reduce respiratory instability during sleep by reducing chemoresponsiveness and/or increasing cerebrovascular reactivity in order to avoid sleep disordered breathing in seniors with sleep apnea. The investigators expect that the findings from this research will lead us to discover novel alternative therapies for sleep apnea in seniors.

Source link: https://clinicaltrials.gov/ct2/show/NCT02703220


Oximetry for Diagnosis of Obstructive Sleep Apnea Syndrome in Children

The gold standard examination for the diagnosis of obstructive sleep apnea syndrome in children is video-polysomnography with video surveillance and monitoring by a nurse to reposition the sensors if needed during the night. But the vPSG is a cumbersome exam that is often impossible to perform in children, with many sensors and electrodes to install on a child's body, which is time-consuming for installation and analysis. Video-respiratory polygraphy is very similar to vPSG, but without EEG, EOG, and EMG electrodes, it is much like vPSG. vPG stands as an alternative to OSAS diagnosis. Since most respiratory disorders are related to desaturations, most respiratory disorders can be attributed to desaturation, the desaturation index obtained by simple portable oximetry could be used for diagnosis of OSAS. The oximetry index obtained by the oximetry performed at the same time as the v can identify an OSAS in children, according to the study's hypothesis.

Source link: https://clinicaltrials.gov/ct2/show/NCT05634096


Ansa Cervicalis and Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea

Obstructive Sleep Apnea is a common disorder characterized by repeated upper airway collapse due in part to a lack of neuromotor tone in particular upper airway muscles, with multiple related health sequelae affecting millions of Americans. Despite the recent promising growth of hypoglossal nerve stimulation as a surgical procedure, its results are limited and a minority of eligible patients do not receive sufficient response, leaving a critical need for safe therapeutic alternatives to PAP. The investigators' main conclusion is that ACS resolves specific anatomic and neuromuscular deficiencies in upper airway control that restores pharyngeal patency in patients with OSA. During flow-limited breathing in sedated humans, the degree of end-expiratory lung volume decrease in sleep correlates with observed increases in pharyngeal collapsibility, and unilateral ACS increases maximum inspiratory airflow and velopharyngeal cross-sectional area.

Source link: https://clinicaltrials.gov/ct2/show/NCT05501236


Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)

The overall aim of this randomized clinical trial is to determine the safety of a novel personalized approach to the surgical treatment of OSA in children with Down syndrome. In the general pediatric population, the estimated prevalence of obstructive sleep apnea in children with DS ranges from 45-83% to 1-6%. According to evidence, AT is significantly less effective in children with DS than in the general pediatric population, with 48 to 95% of children with DS experiencing persistent OSA after AT. Using a flexible endoscope guided through the nose into the pharynx, drug-induced sleep endoscopy allows direct observation of the sites and patterns of pharyngeal blockage during sedated sleep. The investigators found that children with DS are more susceptible to tongue base and supraglottic obstruction than non-DS children, indicating the need for more customized surgical solutions that are tailored to the common causes of obstruction in this population. To test this theory, the investigators plan to examine children with DS and OSA ages 2-18 years with the following specific objectives: Aim 1: Compare the medical results of DISE-directed surgery vs. AT in children with DS and OSA. The investigators report a randomized single-blind comparative effectiveness trial of AT vs. DISE-directed sleep surgery for the treatment of OSA in children with DS. The investigators' main aim is that a personalized surgical intervention based on DISE findings would be more effective in treating OSA in children with DS than the traditional AT.

Source link: https://clinicaltrials.gov/ct2/show/NCT05508971


Prevalence of Obstructive Sleep Apnea Syndrome in Type 1 Diabetic Patients Treated With Insulin Pump (At1Home)

Sleep apnea syndrome is a public health issue due to its high incidence and high incidence, high morbidity, and mortality, but one particularly notable feature of this condition is its relationship with metabolic disorders, particularly diabetes.

Source link: https://clinicaltrials.gov/ct2/show/NCT02796534


Subclinical Cardiovascular Impairments in Patients With Obstructive Sleep Apnea Syndrome

SAS's secondary goals: Which are the anthropometric and/or severity of SAS, allowing us to anticipate the onset of symptoms of cardiac function and/or rhythmic anomalies in patients SAS? After 3 to 6 months of therapy, what are the cardiovascular consequences of a SAS therapy by Continuous Positive Pressure? Do the early cardiovascular attacks and/or the genetic abnormalities reveal early cardiovascular disease and/or metabolic abnormalities in this population of patients with SAS make it possible to predict cardiovascular events?

Source link: https://clinicaltrials.gov/ct2/show/NCT01089257


A Randomized Trial of Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

Emerging evidence points point to a correlation between sleep disordered breathing and poor pregnancy outcomes. Women with obstructive sleep apnea, in particular, may be at a higher risk of both hypertensive disorders of pregnancy and gestational diabetes. A random controlled trial of 1,500 women to see if reducing the incidence of hypertensive disorders of pregnancy following continuous positive airway pressure could result in a decrease in the incidence of obstructive sleep apnea.

Source link: https://clinicaltrials.gov/ct2/show/NCT03487185


The Effect of Fibromyalgia Syndrome Accompanying Obstructive Sleep Apnea Syndrome on Clinical Findings

After being evaluated in the sleep laboratory of the Research Hospital Department of Chest Diseases, our research will be carried out on patients diagnosed with OSAS. According to the 2010 American College of Rheumatology diagnostic criteria, patients with FM will be divided into two groups as FM patients and patients who do not comply with these criteria. The Fibromyrgia impact questionnaire will be used to fibromyalgia patients. Our assumption is that OSAS patients with FMS may have more exhaustion, anxiety, depression, lower algometer values, and more severe OSAS findings in polysomnographic results.

Source link: https://clinicaltrials.gov/ct2/show/NCT05367167

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions