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Sleep Apnea - Astrophysics Data System

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Last Updated: 12 January 2023

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Chronic intermittent hypoxia, a hallmark of obstructive sleep apnea, promotes 4T1 breast cancer development through endothelin-1 receptors

The association of obstructive sleep apnea and cancer is still unclear, and statistics on the association between OSA and breast cancer progression are also uncertain, although the association between OSA and breast cancer progression is vague. Basic science studies are the most effective way to properly address the topic since conclusive epidemiological studies need large sample sizes and long duration of exposure before incident cancer occurrence. Original in vitro and in vivo models were used where 3D-spheroids or cultures of murine 4T1 breast cancer cells were introduced to IH cycles, and nude NMRI mice, orthotopically implanted with 4T1 cells, were exposed to continuous IH exposure prior and after implantation. macitentan, a dual endothelin receptor antagonist, was investigated into the role of the endothelin-1 in encouraging cancer cell proliferation. These findings show that intermittent hypoxia exposure promotes breast cancer formation and malignancy, as well as that dual endothelin receptor blockade blocks intermittent hypoxia-induced tumor formation.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..1212916M/abstract


Inter-sleep stage variations in corrected QT interval differ between obstructive sleep apnea patients with and without stroke history

We wanted to find QTc interval variations in various sleep stages in OSA patients and whether nocturnal QTc intervals differ between OSA patients with and without stroke history. The investigation of 18 OSA patients with previously diagnosed stroke and 18 OSA patients with no stroke history was investigated. QTc intervals in patients with stroke history were significant higher in patients with stroke history regardless of age, sex, body mass index, or OSA severity, in comparison to those without prior stroke history. Both patient groups' QTc intervals were elevated with increased N3 sleep and REM sleep. In addition, QTc intervals in both groups increased gradually toward deeper sleep; however, the severity of changes in patients with stroke history was noticeably greater. OSA patients with a previous stroke have an elevated risk of ventricular arrhythmogenicity and sudden cardiac death, particularly in deeper sleep, according to the results of this research, which has also raised the risk of ventricular arrhythmogenicity and sudden cardiac death.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1778520E/abstract


Development and validation of a metabolite index for obstructive sleep apnea across race/ethnicities

Obstructive sleep apnea is a common disorder that causes ongoing episodes of upper airway blockage during sleep that result in oxygen depletion and sleep fragmentation, which are also associated with an elevated risk of adverse health outcomes. In the Hispanic Community Health Study/Study of Latinos, we examined 219 metabolites and their relationships with the apnea index and moderate-severe OSA to find a subset of metabolites closely related to OSA, which was used to create a metabolite index for OSA. Both adjusted for demographics, lifestyle, and comorbidities, the OSA metabolite index, which is composed of 14 metabolites, was associated with a 50% increased risk for moderate-severe OSA in HCHS/SOL and 55% elevated risk in MESA. The fidelity of metabolise index in a multi-ethnic dataset shows the adherence of the metabolite index to population heterogeneity.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..1221805Z/abstract


SANReSP: A new Italian questionnaire to screen patients for obstructive sleep apnea

Obstructive sleep apnea is a common, widespread, and underdiagnosed condition. Patients and methods The present study included 2622 patients. Patients who were at least 18 years old, spoke Italian, referred to our sleep clinic for potential OSA, and completed the self-administered SANReSP questionnaire were recruited. 79 percent of OSA patients had apnea-hypopnea index, 68. 7%, AHI u2265 15/h; and 48. 2%, AHI u2265 30/h, according to a nodea survey. AHI's optimal SANReSP score for AHI 265 5/h was > 3, with a sensitivity and specificity of 74. 76% and 67. 92 percent, respectively, and an area under receiver operating characteristic curve of 0. 76. The highest SANReSP score for moderate to severe OSA was > 3 points. The optimal SANReSP score for severe OSA was > 4 for severe OSA. With higher SANReSP scores, the likelihood of OSA increased. The SANReSP questionnaire is a short, easy-to-use, and self-administered screening device for OSA.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1776217R/abstract


Obstructive sleep apnea, myocardial perfusion and myocardial blood flow: A study of older male twins

Quantitative and semiquantitative measurements of myocardial perfusion and absolute blood flow were obtained. After accounting for medical, lifestyle, and behavioral causes, as well as recent history of cardiovascular disease, twins with AHI u226515 had 3. 6 percent higher chances of an abnormality score, AHI's 10-point increase in AHI, rising by 20%. Both twins with OSA were at the greatest risk in twin pairs, where both twins had OSA exhibited the highest risk. By AHI status, there were no differences between measures of ischemia and absolute myocardial blood flow and flow reserve. OSA is a disorder of myocardial perfusion abnormalities that indicate prior subpocardial scarring or infarction.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1778420V/abstract


Obstructive sleep apnea in young Asian adults with sleep-related complaints

The purpose of this research, which is attached to a tertiary medical center, was to determine the proportion of young OSA adults with sleep-related complaints in a sleep center. This research reveals a steady decrease in the number of young adults with OSA from 2000 to 2017. Among 371 young patients with OSA among 2378 patients receiving PSG in our sleep center from 2016 to 2017, we further analyzed their characteristics. Despite increasing total numbers with the years, young adults constituted a substantial and relatively stable number of examinees of PSG and confirmed OSA cases, suggesting that young adults constituted a substantial and relatively stable number of investigators of PSG and confirmed OSA cases even as the total number increased with the years. Young adults with OSA tend to be restless, have a higher body mass index, and have a higher risk of cigarette smoking and alcohol use. Young adults with OSA have constituted a small percentage of all confirmed OSA cases throughout time.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..1220582C/abstract


Oropharyngeal obstruction and respiratory system compliance are linked to ventilatory control parameters in pediatric obstructive sleep apnea syndrome

Instable ventilation regulation is an endotypic characteristic of obstructive sleep apnea syndrome. This paper sought to investigate the correlations between the anatomical compromise of the upper and lower airways and ventilation control in otherwise healthy children suffering from moderate to severe OSAS. Oropharyngeal obstruction was associated with reduced CG0 and LG0, but nasal congestion did not change ventilatory control settings. In a multivariate analysis, medium-Frequency PG was negatively related to minute ventilation and respiratory system compliance.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..1217340B/abstract


The role of 3D speckle tracking echocardiography in the diagnosis of obstructive sleep apnea and its severity

There is a strong correlation between obstructive sleep apnea and cardiovascular disease. In assumption, three-dimensional speckle tracking echocardiography is in principle better than 2D STE because it exceeds the standard 2D echo limitations. We recruited 69 patients with OSA and 37 healthy volunteers who underwent a cardiorespiratory sleep study. In all participants, the NT pro BNP plasma level was also measured. Patients with OSA were reduced in patients with 3D RV GLS and 3D RVEF in comparison to healthy individuals. 3D Strain results had greater correlation to standard 2D measurements than 3D RVEF. OSA estimation using 3D STE may be a quick and accurate way. Consequently, 3D RV GLS is a useful device for determining the RV's global presence in OSA because it correlates well with other established measurements of RV systolic activity. Moreover, 3D RV GLS was a useful tool in identifying severe cases of OSA, while NT pro BNP showed no connection, in addition.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..1222347C/abstract


Co-existing obstructive sleep apnea reduces Nuss surgery efficacy in pectus excavatum

Patients with obstructive sleep apnea experience regular PE-related sternal depression during sleep. As the prevalence of OSA in PE patients is higher than the average, co-existing OSA in PE patients may reduce the success of Nuss surgery. In total, 20 adult patients with PE only and nine patients with PE and OSA were analyzed, as well as 9 patients with PE and OSA. The study revealed that percentage changes in SVD in patients with PE solely at 3, 6, and 24 months postoperatively were significantly higher than those in PE and OSA patients. However, percentage changes in RHI were noticeably lower in patients with PE alone than in those with PE and OSA. Patients with PE could have coexisting OSA, according to this analysis, coexisting OSA may reduce the effectiveness of Nuss surgery for patients with PE. Since bar ban removal, we recommend that patients with PE be evaluated and treated for OSA before surgery to prevent surgical failure.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1777494H/abstract


Nocturnal hypoxemia is related to morning negative affectivity in untreated patients with severe obstructive sleep apnea

The relationship between sleep apnea and morning affectivity is also uncertain. We wanted to find out how sleep disruption in patients with obstructive sleep apnea influences their affectivity. According to the apnea-hypopnea index, mild to moderate OSA and aggressive OSA groups were divided into two groups: mild to moderate OSA and severe OSA groups. In the whole population, affectivity and OSA severity markers were found; however, the severe OSA group had a significantly higher cumulative percentage of sleep time at saturations > 90%, which exacerbated morning negative affectivity.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..1221262K/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions