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Skin Cancer - Europe PMC

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Last Updated: 27 November 2022

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Risk assessment of occupational skin cancer among outdoor workers in southern Spain: local pilot study.

Objection Overexposure to ultraviolet radiation is the most common preventable cause of skin cancer. This research seeks to determine occupational photoexposure and photoprotection among outdoor workers employed by a municipality in southern Spain. Conclusions The median effective erythema dose during the working day was 379. 4 J/m 2, or 3. 8 standard erythema doses, was almost three times higher than the recommended maximums for an 8-hour workday. The presence of actinic lentigines, actinic keratoses, and skin cancer were discovered during a skin examination. The CHACES questionnaire revealed a sunburn rate of 50. 1 percent. This is the first study to assess UV radiation exposure, occupational sun protection, sunburn, and actinic injuries of different outdoor workers in one of Spain's sunniest regions, and it emphasizes the need for swift measures to safeguard outdoor workers' wellbeing.

Source link: https://europepmc.org/article/MED/36424170


Microwave-Induced CuO Nanorods: A Comparative Approach between Curcumin, Quercetin, and Rutin to Study Their Antioxidant, Antimicrobial, and Anticancer Effects against Normal Skin Cells and Human Breast Cancer Cell Lines MCF-7 and T-47D.

We investigate the chemical properties of curcumin, quercetin, and rutin by coating them onto porous CuO nanorods herein. In the presence of the anionic stabilizer sodium dodecyl sulfate, the CuO NRs were synthesized by a chemical reaction between CuSO 4 0H 2 O and NaOH. Both microscopic techniques: high-resolution transmission electron microscopy and field emission scanning electron microscopy were used to investigate CuO NRs' surface and surface morphology. The radical scavenging capacity of the 2,2-diphenyl-1-picrylhydrazyl radicals was measured in comparison to the control group. Both Gram-positive bacterial strains, including Staphylococcus and Bacillus subtilis, as well as Gram-negative bacterial strains, including Salmonella typhi, Pseudomona aeruginosa, Escherichia coli, and Klebsiella pneumoniae, were observed. T-47D and MCF-7 were shown with excellent anticancer activity against normal skin cells and breast cancer cells.

Source link: https://europepmc.org/article/MED/36417758


Local control comparison of early-stage non-melanoma skin Cancer (NMSC) treated by superficial radiotherapy (SRT) and external beam radiotherapy (XRT) with and without dermal image guidance: a meta-analysis.

Tumor visualization can be performed before, during, and after therapy, as shown by a new device that combines a 22 megahertz dermal ultrasound with SRT that has improved cure rates and reduced recurrences. Methods We conducted a meta-analysis comparing the local control of four studies using traditional non-image-guided radiotherapy for NMSC treatment to two seminal studies using high-resolution dermal ultrasound-guided SRT. Cell carcinoma, squamous cell carcinoma, and squamous cell carcinoma in-situ lesions were among the four traditional radiotherapy studies uncovered in an article published by the American Society of Radiation Oncology on curative radiotherapy therapy of basal cell carcinoma, squamous cell carcinoma, and squamous cell carcinoma in-situ lesions. Results LC rates in the two US-SRT studies were found to be statistically superior to the four traditional therapies, both individually and collectively. In all subtypes with p-values ranging from 0. 01 to p = 0. 0438, statistically superior results for US-SRT were found when stratified by histology.

Source link: https://europepmc.org/article/MED/36414760


The health-related quality of life of lung cancer patients with EGFR-TKI-related skin adverse drug reactions and its relationship with coping style and self-management.

Purpose The purpose and other determinants of non-small-cell lung cancer patients under targeted anti-cancer therapy have not been investigated. This report was designed to firstly assess the quality of life of health-related quality of life, followed by an analysis of coping styles, self-management, and health-related quality of life of NSCLC patients with skin adverse drug reactions under targeted therapy. Methods We conducted a cross-sectional analysis of 536 NSCLC patients with skin adverse drug reactions under targeted therapy in cancer clinics of three hospitals in China between May 2020 and May 2021. Results The total score of health-related quality of life in 536 NSCLC patients with skin adverse drug reactions undergoing targeted therapy was 46 u00b1 12. 84. NSCLC patients with skin adverse drug reactions after targeted therapy had a poor health-related quality of life, according to the NSCLC's report.

Source link: https://europepmc.org/article/MED/36400979


Picosecond Infrared Laser Mass Spectrometry Identifies a Metabolite Array for 10 s Diagnosis of Select Skin Cancer Types: A Proof-of-Concept Feasibility Study.

A large number of skin cancer cases are now being tested for each true skin cancer case, prompting the need for a fast, high sensitivity, and specificity skin cancer detection system to reduce the number of unnecessary biopsies isolated from benign tissue. Despite tissue loss from the immediate laser sampling site and being able to be configured using selective laser pulses to prevent thermal damage to normal skin, PIRL-MS tests have been further demonstrated to be useful with downstream gross histopathologic examinations. Therefore, PIRL-MS may be used as a decision-support device to reduce both the subjectivity of clinical diagnosis and the number of unnecessary biopsies currently required for skin cancer testing.

Source link: https://europepmc.org/article/MED/36395434


Applications of Metallic Nanoparticles in the Skin Cancer Treatment.

Skin cancer is one of the most common cancers worldwide, divided into two major groups melanoma and nonmelanoma. The local treatment plans play a vital role in skin cancer care. MNPs are mostly due to their ability to carry a substantial dose of medication, which results in a high percentage of anticancer drugs at the target site. MNPs have been used as drug carriers for the purpose of skin cancer treatment and drug delivery. MNP development MNPs can improve the success of several cancer therapies. In vitro and in vivo for the skin cancer therapy, different types of NPs, such as inorganic and organic NPs, have been tested. This report is aimed at investigating the use of MNPs in the skin cancer treatment.

Source link: https://europepmc.org/article/MED/36420097


Multiclass Skin Cancer Classification using Ensembled Deep Learning Model

Skin cancer is a significant health problem, with 125,000 new melanoma cases diagnosed each year. It has been reported that inexperienced dermatologists can compromise the diagnostic accuracy of skin lesions. Skin cancer early detection can reduce mortality, which may lead to reduced mortality. Deep learning has outperforms human experts in a variety of computer vision tasks, according to previous study. 10,000 photographs from the HAM10000 dermoscopy image database were used in this research, including lesions with and without melanoma, as the pre-trained models in an ensemble deep learning strategy. Dermatologists can detect skin cancer with the appropriate technique, as a result, it may have shortened cancer detection, which is vital for effective therapy.

Source link: https://europepmc.org/article/PPR/PPR571551


Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes.

The skin is the largest organ of the human body and is vulnerable to many diseases, including cancer; it is therefore the first line of defense against exogenous biological and non-biological agents. Indeed, increasing evidence shows that transcription factors deregulation caused by genetic, epigenetic, and signaling anomalies plays a significant role in the development of cutaneous malignancies and therapeutic difficulties, including cancer stemming and reprogramming. We also discussed the therapeutic benefits of targeting aberrantly expressed TFs in skin cancers with bioactive natural products and/or synthetic agents.

Source link: https://europepmc.org/article/MED/36372325


Relationship between Fitzpatrick Skin Type and The Cancer Genome Atlas Classification with Melanoma-Related Metastasis and Death in 854 Patients at a Single Ocular Oncology Center.

The Fitzpatrick Skin Type is a noninvasive way of determining patients based on skin color and sunburn sensitivity. The Cancer Genome Atlas is a tool that helps patients with uveal melanoma in patients with uveal melanoma caused by genetic mutation of the tumor. Materials and methods The objective cohort study on 854 patients with uveal melanoma treated at a single tertiary ophthaloncology center between 2006 and 2020 was based on FST on a scale of I-VI and based on genetic testing, including a report on a scale of A, B, C, and D, and D. Outcome measures included uveal melanoma treatment using FST on a scale of A, B, C, Patients who were not FST I had a higher risk of being TCGA group D, according to Patients who were not categorized as FST I. Patients classified as FST I are more likely to experience melanoma on genetic testing, while those labeled FST III-V show lower grade melanoma.

Source link: https://europepmc.org/article/MED/36369870


Skin cancer signal associated with phosphodiesterase inhibitors: gaining insight through the FDA pharmacovigilance database.

Results Sildenafil Associated ROR numbers and IC 025 ranged from 9. 19 for metastatic malignant melanoma to 132. 23 for malignant melanoma stage II. ROR and IC 025 in Tadalafil, Tadalafil's Twinning malignant melanoma stage II, and IC 025 for malignant melanoma stage II ranged from 6. 79 to 180. 17 for benign melanoma stage II. Vardenafil branded ROR and IC 025 began from 23. 38 for metastatic malignant melanoma to 245. 77 for malignant melanoma stage III. Conclusions This research reveals that the relationship between sildenafil, tadalafil, and vardenafil was linked to skin cancer risk in erectile dysfunction patients.

Source link: https://europepmc.org/article/MED/36334066

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions