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Skin Cancer - Europe PMC

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Last Updated: 27 April 2022

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Validation of artificial intelligence prediction models for skin cancer diagnosis using dermoscopy images: the 2019 International Skin Imaging Collaboration Grand Challenge.

Background analysis These studies have shown that AI-based dermatology algorithms have higher diagnostic accuracy than expert dermatologists, and that surgical diagnostic analysis could not adequately assess clinically realistic scenarios, such as when presented with images of disease categories that are not included in the training database or images obtained from statistical databases with significant shifts from training distributions. With the intention of informing clinicians and regulatory agencies about safety and real-world accuracy, we decided to simulate these real-world scenarios and evaluate the effects of image source institution, disorders outside of the training process, and other image artifacts on classification accuracy. Methods We developed a large dermoscopic image classification challenge to determine machine learning algorithms' results for the task of skin cancer diagnosis from dermoscopic images, and how this performance is affected by shifts in statistical distributions of data, disease classes that are not represented in training datasets, and imaging or lesion artifacts. The calibrated algorithms were then tested for balance against the HAM10000 and BCN20000 test datasets and reports from countries not included in the training dataset. Images of all diagnostic groups available in preparation as well as other conditions not included in training results were included in test results. Interpretation of the Interpretation Theme of We have identified specific deficiencies and safety issues in AI diagnostic protocols for skin cancer that could be addressed in future diagnostic testing protocols to increase safety and reliability in clinical practice.

Source link: https://europepmc.org/article/MED/35461690


A SHort course accelerated radiotherapy (SHARON) dose-escalation trial in older adults head and neck non-melanoma skin cancer.

In the treatment of non-melanoma skin cancers in older patients, the aim was to determine the efficacy and safety of a SHort-course Accelerated RadiatiON therapy program. Methods used to enroll old patients with histologically confirmed non-melanoma skin cancers. In two days, the radiotherapy regimen was based on the production of four radiotherapy fractions with a bd fractionation in two days in a row. Among the fourteen patients who completed the one cycle, only one experimented acute G4 skin irritation. According to two and three RT cycles, nine and seven patients underwent two and three cycles, respectively: of these, no G3 toxicities were found. Patients treated with one course and two others were 78. 7 and 77. 8%, respectively, in patients treated with one course and more courses. Conclusions: In older patients with non-melanoma skin cancers, short-course radiotherapy is well tolerated. Advances in knowledge This strategy may be a viable alternative for older adults with nMSC, whether palliative or curative in the goal, according to the patient's condition.

Source link: https://europepmc.org/article/MED/35451856


An update on local and systemic therapies for nonmelanoma skin cancer.

Introduction Nonmelanoma skin cancers as a group outnumber the prevalence of all other malignancies combined. Basal cell carcinoma, squamous cell carcinoma, and Merkel cell carcinoma are among the NMSC's cancers. We expect treatment decisions to become more complex and personalized with time. The role of systemic immunotherapies and neoadjuvant therapies in the treatment of NMSC is also unclear. Local intervention using intralesional injections and isolated limb infusion may be useful alternative therapies.

Source link: https://europepmc.org/article/MED/35412413


An integrated skin cancer education program in renal transplant recipients and patients with glomerular disease

In immunosuppressed patients at risk of skin cancer, sun-protective strategies focusing on skin cancer prevention are required. The aim of this research is to determine the effects of an integrated skin cancer education program on skin cancer education and sun-protective behaviors in renal transplant recipients and patients of chronic renal transplant recipients and patients with long-term immunosuppressants treated with long-term immunosuppressants. A pilot prospective cohort study was conducted in Central Queensland, Australia, among adult RTRs and patients with GD who conducted research on skin cancer and sun-health information, sun-protection strategies, and skin examination pre- and post-education. RTRs had higher compliance with sun-protective products and higher skin examination rates by themselves and/or general practitioners before and after the intervention of education relative to patients with GD. To conclude, an integrated skin cancer and skin health education program enhanced knowledge of skin cancer and skin health, as well as the frequency of self-skin examinations and formal skin assessments.

Source link: https://europepmc.org/article/PPR/PPR483633


Characteristics, treatment and outcomes of 589 melanoma patients documented by 27 general practitioners on the Skin Cancer Audit Research Database.

Multiple Australasian general practitioners are investigated, despite being previously uninscribed. Methods The characteristics, administration, and outcomes of 589 melanoma patients, managed by 27 Australasian general practitioners and published on the Skin Cancer Audit Research Database were analyzed. Compared to 1. 99 mm for those referred to other experts, the average Breslow thickness of invasive melanomas re-excised by general practitioners was 0. 67 mm compared to 1. 99 mm for those referred to other specialists. Out of 205 patients with invasive melanoma, 14 of whom have developed to metastatic disease, with 50% of these being associated with nodular melanoma. Patients with invasive melanoma had a 5-year survival rate of 95. 2%. Conclusions A series of melanoma patients by Australasian general practitioners were closely aligned with new recommendations and 5-year survival with respect to invasive melanoma was at least as favourable as national population-based estimates.

Source link: https://europepmc.org/article/MED/35437755


Atopic Dermatitis and Skin Cancer Risk: A Systematic Review.

Introduction Atopic dermatitis is one of the most common skin disorders, and it can be attributed to skin cancer risk. We wanted to investigate the connection between AD and skin cancer risk. Results We evaluated 16 studies involving a total of 9,638,093 participants evaluating the relationship of AD to skin cancers in an ongoing database. AD was also linked to an elevated risk of skin cancer in general, according to a pooled review of 16 studies. AD was scientifically linked to an elevated risk of basal cell carcinoma and squamous cell carcinoma, according to Subgroup pooled results. AD was also correlated with an elevated risk of nonmelanoma skin cancer, BCC, and SCC, but not melanoma risk, according to a cohort analysis. The mechanism of AD contributing to skin cancer is not clear, and further research is required to investigate the possibility of a potential pathogenesis.

Source link: https://europepmc.org/article/MED/35430723


An Exploration of the Use and Impact of Preventive Measures on Skin Cancer.

Background The most common form of cancer is skin cancer, and both clinical and epidemiological studies show that cumulative solar doses and the number of sunburns are related to skin cancer. More than 5. 4 million new cases of skin cancer are reported each year, causing significant health and financial difficulties. Conclusions Sunscreen use was correlated to a reduced risk of skin cancer, while long-sleeved shirts and remaining in the shade were not significantly related to lower skin cancer rates, implying that these steps may not be as effective as sunscreen for preventing skin cancer. These findings may help guide future education and research into skin cancer prevention, as well as the need to develop male-oriented services to reduce gender gaps in applying sun-protection products.

Source link: https://europepmc.org/article/MED/35455920


Risk of a Second Skin Cancer in a Cohort of Patients With Nonmelanoma Skin Cancer- Basal Cell Carcinoma or Squamous Cell Carcinoma- Treated With Mohs Micrographic Surgery: A National Prospective Cohort Study.

Background Patients with keratinocyte disease or non-melanoma skin cancer are at a higher risk of developing a second cutaneous malignant neoplasm. In a patients cohort treated with Mohs Micrographic Surgery, our aim was to describe the prevalence, incidence rate, and risk factor predisposing to the creation of a second neoplasm. Methods Prospective cohort of consecutive patients undergoing MMS in 22 representative Spanish centers REGEMOHS. MMS' findings include 4768 patients underwent MMS: 4397 basal cell carcinoma and 371 cutaneous squamous cell carcinoma. Incidence rate for any cancer was 107 per 1000 people-year; 90 basal cell carcinoma, 14 cutaneous squamous cell carcinoma, and 2 melanoma. Previous history of multiple tumors before diagnosis, immunosuppression, and male neoplasm were among the risk factors for developing a second cutaneous malignant neoplasm. Patients with keratinocyte carcinoma who underwent MMS are at a higher risk of acquiring a second cutaneous malignant neoplasm.

Source link: https://europepmc.org/article/MED/35436493


Rosmarinus officinalis L. Leaf Extracts and Their Metabolites Inhibit the Aryl Hydrocarbon Receptor (AhR) Activation In Vitro and in Human Keratinocytes: Potential Impact on Inflammatory Skin Diseases and Skin Cancer.

Aryl hydrocarbon receptor activation by environmental agents and microbial metabolites could be responsible for a string of skin disorders. Hence, it would be imperative to find natural compounds that may prevent AhR activation by microbial origins such as 6-formylindolo, indirubin, and pityriazepin or the prototype ligand 2,3,7,8-toxin. In the presence of [3 H]TCDD, five distinct dry Rosmarinus officinalis L. extracts were dissatisfied with their roles as antagonists of AhR ligand binding with guinea pig cytosol. Against TCDD, FICZ, PZ, and IND, the methanolic ROE was even assayed toward CYP1A1 mRNA gene induction using RT-PCR in human keratinocytes. At 100 ppm, all assayed ROE extracts demonstrated similar dose-dependent metabolism with almost no inhibition of AhR activation by TCDD at 100 ppm. TCDD and the Malassezia metabolites FICZ, PZ, and IND inhibit AhR activation by TCDD and IND.

Source link: https://europepmc.org/article/MED/35458697


Skin Cancer Management: Current Scenario and Future Perspectives.

Skin cancer is a life-threatening disease that has resulted in significant human health around the world. Sunlight has been known to be the most common cause of skin cancer in the twentieth century. UV radiations are the most common factor responsible for skin cancer. The cutaneous melanoma was mainly due to the sun's recurrent exposure, according to a novel hypothesis by U. S. scientists, whereas keratinocyte cancer arose as a result of gradual sun exposure. Skin cancers have been treated to some degree since the X-rays' invention, but the results are uncertain because it is dependent on the patient's type of tumour and surgical treatment. Various nanocarriers, magnetic nanoparticles, gold nanoparticles, carbon nanotubes, etc. have been potential participants in the management and prognosis of both non-melanoma and melanoma skin cancer's diagnosis and prognosis.

Source link: https://europepmc.org/article/MED/35422227

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions