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Skin Cancer - ClinicalTrials.gov

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Last Updated: 27 April 2022

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The Organ Transplant Recipient HPV and Skin Cancer Study

APAMS The objective of this research is to determine the prevalence, type-specific prevalence, occurrence, and persistence of cervical HPV infection in OTRs relative to immunocompetent controls. Comparing to immunocompetent controls, To determine the overall and type-specific prevalence of oral HPV infection in female OTRs and type-specific infections. To determine the role of lifestyle and societal causes for the occurrence of cervical and oral HPV infection in female OTRs. In female OTRs compared to immunocompetent controls, we want to determine the prevalence and incidence of HPV-related dysplasia and cancer in female OTRs. To determine the role of lifestyle, medical, and organ transplantation-related causes for the prevalence and incidence of skin dysplasia in OTRs. In OTRs, the researchers will investigate links between skin dysplasia and the incidence of cervical HPV infection and VZV infection. METHODS The research will be conducted as a prospective cohort study in a clinical setting. OTRs is a publishing company that publishes reports about individuals: At baseline: Questionnaire, dermatologic skin analysis, analysis of skin photodamage, medical record data, certifico-vaginal HPV self-sample test, oral sample for future study, blood sample for vitamin D test — obstructive skin analysis — OTRs is a division of the University of OTRs. After 6 months: A new blood sample for vitamin D test was obtained. After 12 months: New cervico-vaginal HPV self-sample test was repeated. A baseline HPV self-sample test, assay sample for HPV testing, will be collected from female immunocompetent controls. After 12 months: A new cervico-vaginal HPV self-sample examination was administered after 12 months.

Source link: https://clinicaltrials.gov/ct2/show/NCT05284877


At-Home Dermoscopy Artificial Intelligence for Optimizing Early Triage of Skin Cancer

To determine whether having access to at-home dermoscopy with mole scanning artificial intelligence improves triage of suspicious skin lesions II. To determine whether having access to at-home dermoscopy with mole scanning artificial intelligence improves identification of suspicious skin lesions III. The discovery of suspicious skin lesions IV has been delayed due to a lack of access to at-home dermoscopy with mole scanning artificial intelligence. At home for six months, patients perform self-skin examinations using naked-eye technology.

Source link: https://clinicaltrials.gov/ct2/show/NCT05321784


Calcipotriol Plus 5-Fluorouracil Immunotherapy for Skin Cancer Prevention in Organ Transplant Recipients

The primary aim of this investigator-initiated clinical trial is to determine the efficacy of topical calcipotriol and 5-fluorouracil treatment in OTRs on immunosuppressive drugs with precancerous skin lesions identified as actinic keratoses and a history of non-melanoma skin cancer in order to avoid AKs and prevent squamous cell carcinoma formation. Our previous studies have established that calcipotriol in combination with 5-FU can cause an antitumor immunity against AKs in immunocompetent patients. The induction of strong T cell immunity and TRM cell formation against AKs are both contributing to this SCC risk reduction.

Source link: https://clinicaltrials.gov/ct2/show/NCT04642287


Phase 1 Trial of Intralesional Immunotherapy With IFx-Hu2.0 Vaccine in Patients With Advanced Non-melanoma Skin Cancers

Approximately twenty adult patients of any sex, ethnicity, and race of histologically confirmed advanced non-melanoma skin cancers with visible lesions would be eligible for study enrollment and treatment with IFx-Hu2. 0. These types of rare in the pediatric population, with only limited case reports. Since the findings of this study are published, the possibility for the manufacture of this product for pediatric patients with non-melanoma skin cancers will be determined. At every drug administration visit, blood will be obtained from these patients prior to treatment administration. As well as immune response testing, blood samples will be drawn at the same time as immune response evaluations. This is mainly a safety study that is intended to assess IFx-Hu2. 0 monotherapy and provide baseline facts to potentially support further studies into IFx-Hu2. 0 + anti-PD-1 combination therapy for patients with non-melanoma skin cancers.

Source link: https://clinicaltrials.gov/ct2/show/NCT04160065


Calcipotriol Plus 5-Flourouracil Immunotherapy Before Transplantation for Skin Cancer Prevention in Organ Transplant Recipients

The primary aim of this investigator-initiated clinical trial is to determine the safety of topical calcipotriol and 5-flourourouracil treatment in organ transplant recipients with precancerous skin lesions and a history of skin cancer in order to prevent squamous cell carcinoma formation after transplantation. We have reported the high success of topical calcipotriol plus 5-FU immunotherapy for AKs on the face and scalp, dramatically lowering the risk of SCC disease in immunocompetent patients within three years post-treatment. The induction of robust T cell immunity and TRM cell formation against AKs is accompanied by robust T cell immunity and TRM cell formation. In immunocompetent patients, our latest research shows the synergistic effects of calcipotriol in combination with 5-FU on a robust T cell immunity against early skin carcinogenesis.

Source link: https://clinicaltrials.gov/ct2/show/NCT04329221


In Vivo Confocal Microscopy of Cutaneous Neoplasms and Normal Skin

This research is designed to test new non-invasive imaging techniques for the diagnosis of skin lesions as well as normal skin. Our primary aim is to gather and analyze these photographs of various skin lesions, as well as matching biopsy specimens. The long-term aim is to develop a method that will help identify skin cancer early and minimize the need for numerous skin biopsies. To show the OCT imaging location of lesion, real-time color images taken by the same goal with OCT are also available. The color image can be identified simultaneously on a larger dermoscopic image obtained by an external dermoscope. The precision biopsy will also be compared to the standard shave biopsy or shave excision to see if the diagnostic results are comparable between the two methods. Based on his clinical findings, MSK dermatologist Will perform live remote control imaging consultation.

Source link: https://clinicaltrials.gov/ct2/show/NCT00588315


Ex-vivo Examination of Excisions of Skin Tumors by Confocal Optical Coherence Tomography (LC-OCT) With Integrated Dermoscopy and Comparison With Histology (DERMOCTAV)

There are mainly three types of skin cancer: melanoma, basal cell carcinoma, and squamous cell carcinoma are all three types of skin cancer. The diagnosis of skin cancers is now based on anatomo-pathological data. According to the following basic, the low intensity laser beam delivered by the LC-OCT device interferes with the melanin and makes it possible to obtain a 3D cross-sectional picture of the skin with a resolution of the order of a micrometer. This project aims to establish ex vivo the use of the OCTAV® prototype including the "dermoscope" function before an in vivo application by comparing photographs obtained by the OCTAV® prototype incorporating the "dermoscope" function with those obtained by an in vivo procedure, which are similar to them exactly.

Source link: https://clinicaltrials.gov/ct2/show/NCT05340543

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions