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Skin Cancer - ClinicalTrials.gov

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Last Updated: 27 November 2022

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Presurgical Evaluation of Nonmelanoma Skin Cancers Using High Frequency Ultrasound

Because of its role as a surface covering for the body, the skin allows the implementation of noninvasive diagnostic and investigative procedures. Of all the tumors that affect humans, non-melanoma cutaneous cancer is the most common e. g. Basal cell carcinoma and squamous cell carcinoma were both present in Basal cell carcinoma and squamous cell carcinoma. Ultrasonography, a painless non-radioactive imaging diagnostic technique based on the detection of sound waves through body tissues, has been used in dermatology since the 1970s, but high frequency ultrasound has been used in dermatology since the 1970s.

Source link: https://clinicaltrials.gov/ct2/show/NCT03457766


At-Home Dermoscopy Artificial Intelligence for Optimizing Early Triage of Skin Cancer

To determine if having access to at-home dermoscopy with mole scanning artificial intelligence aids in the detection of suspicious skin lesions III. The test of suspicious skin lesions IV can be detected earlier by a user's at-home dermoscopy with mole scanning artificial intelligence, leading to the earlier detection of suspicious skin lesions IV. Patients perform self-skin examinations using naked-eye tracking and smartphone dermatoscope at home for six months. Patients perform self-skin assessments using naked-eye technology at home for six months.

Source link: https://clinicaltrials.gov/ct2/show/NCT05321784


SSW Works: A Virtual Learning Environment for Occupational Skin Cancer Prevention Phase I

Americans who work outside are exposed to a significant degree of solar ultraviolet radiation over a lifetime that significantly raises the risk of developing skin cancer. The Surgeon General has outlined occupational sun protection as a national priority. Sun Safe Workplaces integrates policy and education to raise workplace efforts on sun safety and employee sun protection techniques. We'll build SSW Works, a virtual learning environment that will help the SSW curriculum be distributed to American workplaces as a result of SBIR Fast-Track's SBIR Fast Track program. SSW Works will help integrate SSW into safety education by increasing appropriateness for Hispanic and African American employees and integrating with the most current learning management technologies. SSW Works, both English and Spanish, will be fully programmed and tested for efficiency by achieving the objectives of: 1 establishing the evidence-based SSW and two others randomized controlled trials with 20 workplaces determining the effects of SSW on employees' sun safety behaviours primary outcome of the SSW Works. The key argument is that employers hired to obtain SSW Work will have more sun protection at posttest than those in the minimal information control group. Because the outdoor workforce is large and at risk for skin cancer, reducing health care costs and saving lives are the only commercial competitors, SSW Works will have a significant effect and commercial success.

Source link: https://clinicaltrials.gov/ct2/show/NCT05146622


Role of Metabolic Enzymes in Non-Melanoma Skin Cancer: Potential for Informative Biomarkers and Therapeutic Targets

The normal skin biopsy will be obtained from a skin area of skin with no suspicious lesions present on a body surface. The skin specimens will be frozen at Beckman Laser Institute chemistry-lab for study and will be assigned with a subject ID number, but there will be no personnel health data attached to the skin specimens. During skin cancer progression, expression of key metabolic enzymes is reduced and/or lost, according to researchers. These two enzymes are responsible for estrogen metabolism, according to new research, a metabolic enzyme called UGT in the genes called UDP-glucuronosyltransferases was shown to have significant reduced expression in breast tumors relative to normal breast tissue from the same patients.

Source link: https://clinicaltrials.gov/ct2/show/NCT02244749


A Randomized, Placebo-controlled, Double-blind, Phase II Chemoprevention Clinical Trial of Topical Diclofenac and DFMO in Subjects With a History of Skin Cancer

The presence, at baseline, of at least eight actinic keratoses on the face, neck, scalp, and arms suggests that participants are at a higher risk of non-melanoma skin cancer, with no documented case of squamous or basal cell skin cancer, continuing or history of actinic keratoses. Once daily and placebo for the topical DFMO once daily, the randomized diclofenac once daily and the topical DFMO's once daily placebo will be switched to: topical diclofenac once daily and a daily placebo for the topical DFMO.

Source link: https://clinicaltrials.gov/ct2/show/NCT04091022

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions