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Cold physical plasma is a partially ionized gas that produces various components that have been identified as potential anticancer agents. In vitro, we therefore tested the cold plasma effects in skin cancer cells. As the plasma source, an atmospheric pressure argon plasma jet was used. Novel indirubin derivatives also have potent anticancer properties, according to new research. When mixed with plasma in skin cancer cells, one drug displayed remarkable synergistic toxicity, which may be promising for future in vivo studies.
The aim of the study was to produce curcumin-loaded nanoparticles of Eudragit E 100 for topical skin applications by a simple, cost-effective method of nanoprecipitation. At acidic and neutral pH, In vitro drug testing was carried out. To determine the ability of curcumin nanoparticles to cross the stratum corneum, an ex vivo skin penetration study was carried out using a vertical Franz diffusion cell. While ex vivo permeation and in vivo studies show promising results of the formulation, drug demonstrations show the acid-responsive behavior of curcumin nanoparticles. It can be concluded from the findings that curcumin nanoparticles could be used as a topical dosage form for skin cancer therapy. Eudragit E100 meets the conditions related to topical use of curcumin for local use for skin cancer treatment.
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