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"This research investigated hub genes and their connection with immune infiltration in obese patients' cardiovascular tissues and tissues of obesity after BS by bioinformatic analysis using Gene Expression Omnibus datasets. " After BS, the number of M1 macrophages was significantly lower in adipose and liver tissue after BS compared to immune cell infiltration analysis. After BS were also linked to immune cells, "ten hub genes that had been all downregulated were all downregulated. ".
Source link: https://europepmc.org/article/MED/35412419
"Part II of this report investigates the predictive capability of the skeletal muscle force model developed in Part I of this research" within the ankle joint complex. The ankle joint's muscle activity was stimulated by five different exercises. The results were then used to verify the results by using muscle contractions as known and all other components of Euler's second law remain unknown. In the second Newton-Euler equation of rigid body motion, this compares ankle joint movements due to calculated muscle forces to the sum of the times due to both other sources and the kinematic terms. With an overall average percent error across all subjects of 8. 2%, average percent error across all subjects of 8. 2%, and maximum percent errors for each subject ranged from 43. 3% to 78. 4% with an overall average maximum of 52. 4%. ".
Source link: https://europepmc.org/article/MED/35388404
"This paper introduces a new way of estimating skeletal muscle forces using a model developed from dimensional analysis. " The derivation begins with a dimensional analysis and a selection of key parameters that define muscle force generation. The ankle joint is used as an example for calculating the equations that eventually result in a system of linear equations. Among other things, a muscle force model that can be calibrated and then used to predict joint contact and surrounding tissue loading is vital in advancing biomechanics research fields such as injury prevention, quality control, and tissue engineering.
Source link: https://europepmc.org/article/MED/35039858
"Aerobic energy needs have contributed to the evolution of complicated mitochondrial reticula in highly oxidative muscles, but the extent to which metabolic challenges can be addressed with evolutionary changes in the physiology of specific mitochondrial fractions remains unsolved. " We investigated mitochondrial pathways that could have contributed to aerobic fitness in deer mice that were accustomed to the hypoxic environment at a high altitude. When compared to low-altitude mice across environments, high-altitude mice had greater yield, respiratory capacity for oxidative phosphorylation, and O2 affinity, but there were no species differences in these characteristics in intermyofibrillar mitochondria. In both mitochondrial fractions, high-altitude mice had increased capabilities of complex II as a result of complexes I + II and higher succinate dehydrogenase activity. Functional changes in subsarcolemmal mitochondria may have contributed to improved aerobic endurance in hypoxia in hypoxia in high-altitude deer mice, according to our findings.
Source link: https://europepmc.org/article/MED/35661419
MiR-142a-39, which is highly expressed in denervated skeletal muscle, is a key component of cell excitability and could interfere with cell excitability by similar mechanisms," says the author. Overexpression of miR-142a-3p reduced cell membrane capacitance, increased potassium current density, and decreased calcium current density, according to the study. MiR-142a-3p decretion channel current density is reduced by a knockdown of miR-142a-3p. The changes in miR-142a-3p expression in C2C12 cells affected the ion channel currents in C2C12 cells, suggesting its potential roles in muscle cell electrophysiology.
Source link: https://europepmc.org/article/MED/34916449
"Muscle regeneration is absolutely vital for vertebrate muscle homeostasis and recovery after injury. " During regeneration, muscle stem cells differentiate into myocytes, which fuse with pre-existing muscle fibers. We suggest that Ca 2+-mediated differentiation, fusion, and contraction be a feature sought in the amniotes to aid muscle recovery.
Source link: https://europepmc.org/article/MED/35689496
"Background Body composition parameters are associated with hypertriglyceridemia-induced pancreatitis," says the author. This report looked at the correlation between muscle mass measurements using computed tomography and the severity of HTGP. Methods The modified CT severity index was calculated from admission examination results. To determine the model's effectiveness, the receiver operating characteristic curves and the corresponding area under the curve were calculated. Patients with poor skeletal muscle mass and high MCTSI were significantly more likely to have moderately severe to severe HTGP. Patients with LSMM had lower body mass index, lower HDL-C level, elevated amylase level, occurrence of surgery, shorter umbilical waist circumference, and longer hospital stay. The TOTAL model, which combined LSMM-MCTSI and clinical risk parameters, performed best, followed by other models. Conclusion In the case of predicting severity, MCTSI's success in predicting severity can be enhanced by considering LSMM, which is a promising treatment for HTGP. ".
Source link: https://europepmc.org/article/MED/35687043
"The current research sought to illustrate the combined effects of rifaximin and Lu2011carnitine on muscle atrophy in cirrhotic rats with steatohepatitis. " For this purpose, a total of 344 Fischer rats were fed a choline-u2011deficient Lu2011 defined diet with the regular oral administration of rifaximin and/or Lu2011carnitine, as well as measurements of psoas muscle mass index and forelimb grip strength were determined. In vitro assays were used to determine the effects of Lu2011carnitine on rat myocytes. In addition, rifaximin reduced muscle mass atrophy and weakness by lowering intramuscular myostatin and pro-u2011inflammatory cytokine levels. paraphrasedoutput:u2013u03b1 -- in vitro assays revealed that Lu2011carnitine specifically reduced mitochondrial biogenesis, thus inhibiting the UPS in rats myocytes that were stimulated with LPS or tumor necrosis factor (u2013), u2013u03b1. The present report reveals that the combination of rifaximin and Lu2011carnitine can have a medical benefit for liver cirrhosis u2011-related sarcopenia. ".
Source link: https://europepmc.org/article/MED/35686541
"Background Gene expression services are closely linked to the complex of active cis regulatory elements mediated by chromatin contacts and related RNAs. " In addition, the distribution and function of chromatin-associated RNAs in gene expression and chromatin conformation are still unclear. To illustrate this, we first present a comprehensive interaction map of 3D chromatin-chromatin interactions and RNA-chromatin interactions, in order to identify genomic variants that contribute to complex skeletal muscle characteristics. A series of candidate functional variants and 54 target genes that have yet to be identified were found, with 71% of these candidate functional variants choosing to skip over their nearest gene to regulate the target gene in a long-range manner. Furthermore, we find that this multi-omics interaction map consists of functional groups that are rich in particular biological functions, and that GWAS target genes can serve as key genes for discovering peripheral trait-related genes. ".
Source link: https://europepmc.org/article/MED/35681201
"We wanted to investigate the links of circulating biomarkers with ASM and HGS in middle-aged black South Africans. " 934 black South Africans from the Middle-aged Soweto cohort were included in this study. MMP-7 was only in the total sample with lower HGS. ASM was also correlated with higher HGS for men, LEP, MEPE, and SCF, among others, and MEPE and SCF were also linked to higher ASM for men, LEP, MEPE, and SCF, as well as higher ASM. Both in men and 37 biomarkers were attributed to lower ASM, with none of these being correlated with lower HGS. In women, there was no biomarker linked to HGS. In conclusion, most biomarkers were associated with ASM and not HGS, and biomarkers with ASM and HGS showed sex-specificity in middle-aged black South Africans, although not HGS. "Future research should also consider sexual dimorphism in the pathophysiology of sarcopenia for the development of sex-specific therapy and diagnostic tools. ".
Source link: https://europepmc.org/article/MED/35680977
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