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Skeletal Muscle - DOAJ

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Last Updated: 12 June 2022

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Integration of genome-wide association study and selection signatures reveals genetic determinants for skeletal muscle production traits in an F2 chicken population

"Improving the production of broiler chicken meat has been a goal of broiler breeding programs around the world for many years. " However, the genetic foundations of chickens' skeletal muscle production characteristics have yet to be fully understood. The integration of GWAS and selection signature studies revealed that genetic determinants responsible for skeletal muscle development characteristics were mostly localized on chromosomes 1 and 4. These findings will help increase our understanding of chicken muscle production genes, and the significant SNPs identified could be promising candidates for integration into practical breeding techniques such as genome-wide selection to raise the meat yield of chickens.

Source link: https://doi.org/10.1016/S2095-3119(21)63805-4


Human umbilical cord-derived mesenchymal stromal cells ameliorate aging-associated skeletal muscle atrophy and dysfunction by modulating apoptosis and mitochondrial damage in SAMP10 mice

"Abstract Background Skeletal muscle mass and function losses in older adults are associated with quality of life decline and disability, as well as disability. Methods and findings We investigated the efficacy of umbilical cord-derived mesenchymal stromal cells on sarcopenia-related skeletal muscle atrophy and dysfunction in senescence-induced mouse prone 10 mice. We randomly assigned 24-week-old male SAMP10 mice to a UC-MSC disease group and control group. In both types of skeletal muscle of the SAMP10 mice, the UC-MSC therapy delayed mitochondria damage, cell apoptosis, and macrophage infiltrations, as well as improved desmin/laminin expression and proliferating cells. Conclusions Our results show that UC-MSCs may provide a promising treatment for sarcopenia/muscle diseases linked to skeletal muscle atrophy and dysfunction by anti-inflammatory, and mitochondrial biogenesis pathways that could be mediated by an AMPK-PGC1-u03b1 axis.

Source link: https://doi.org/10.1186/s13287-022-02895-z


Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight

"Importantly, while DGE showed variable gene network enrichment, DAS was enriched in structural and functional gene networks of skeletal muscle, resulting in the production of alternatively spliced transcript isoforms that have been related to microgravity's physiological transitions, including muscle atrophy and altered fiber type function. " Conclusions Our work serves as the first inquiry into coordinate changes in DGE and DAS in large leg muscles through spaceflight. It gives you a new opportunity to explore the molecular mechanisms by which splice variants of skeletal muscle genes control muscle morphology to microgravity, and how small molecule splicing regulators can improve fiber type function in prolonged spaceflight," says the author.

Source link: https://doi.org/10.1186/s13395-022-00294-9


Nicotinamide Riboside Supplementation to Suckling Male Mice Improves Lipid and Energy Metabolism in Skeletal Muscle and Liver in Adulthood

"Using an animal model, we investigated the long-term programming benefits of mild NR supplementation during the suckling period on lipid and oxidative metabolism in skeletal muscle and liver tissues. " From day 2 to 20 of age, male mice were weaned to a chow diet and switched to a high-fat diet or a normal-fat diet for ten weeks. These pre-clinical results indicate that early postnatal supplementation in early postnatal life positively impacts lipid and energy metabolism in skeletal muscle and liver in adulthood, serving as a potential preventive measure against obesity-related diseases linked to ectopic lipid accumulation. ".

Source link: https://doi.org/10.3390/nu14112259


Gene Expression Profile Provides Novel Insights of Fasting-Refeeding Response in Zebrafish Skeletal Muscle

"However, the de-tailed biological processes and importance by which the benefits of fasting confer health benefits are not yet clear. " Nevertheless, the chemical responses to nutrient metabolism in zebrafish skeletal muscles have yet to be published. We therefore sought to establish a gene expression profile in zebrafish skeletal muscles in reaction to fasting-refeeding. The gene set that had only been elevated after 3 h of refeeding was shorter, meaning that diet-related gene function is linked to gene length.

Source link: https://doi.org/10.3390/nu14112239


Effects of Omega-3 Supplementation Alone and Combined with Resistance Exercise on Skeletal Muscle in Older Adults: A Systematic Review and Meta-Analysis

"Sarcopenia has a detrimental effect on elderly people's bone mass and function. " A systematic review and meta-analysis were published on the effects of a cy3-3 fatty acid supplementation with or without RET on muscle mass and function in older adults. All of the research types involving u03c9-3 fatty acid supplementation on measures of muscle mass and function in older adults were included. The mean differences or standardized mean differences with 95% confidence intervals were calculated and pooled effects assessed. "U03c9-3 fatty acid supplementation did not have an effect on lean tissue mass," lean tissue mass was unaffected by lean tissue mass. ".

Source link: https://doi.org/10.3390/nu14112221


O -GlcNAcylation: The Underestimated Emerging Regulators of Skeletal Muscle Physiology

"O -GlcNAcylation receives and coordinates different signal inputs as an intracellular integrator similar to the nutrient sensor and stress receptor, which are intended for several substrates with spatio-temporal analysis specifically to preserve cellular homeostasis and normal physiological functions. " Our research provides a brief summary of O -GlcNAcylation and its only two processing enzymes and HBP flux, which will help to better understand its physiological functions of sensing diet and environmental cues. This article explores how O -GlcNAcylation helps to treat metabolic disorders and the mystery surrounding skeletal muscle's insulin resistance. Despite the fact that O-GlcNAcylation's crucial role in skeletal muscle physiology has been extensively researched and acknowledged, it is still undermining and dismissed. This paper explores the most recent developments and potential mechanisms of O -GlcNAcylation in the control of muscle contraction and structural properties.

Source link: https://doi.org/10.3390/cells11111789


Impact of high‐intensity interval training with or without l‐citrulline on physical performance, skeletal muscle, and adipose tissue in obese older adults

"Abstract Background Aging is linked to a gradual decrease in skeletal muscle mass and strength, as well as a rise in adiposity. " Mitochondrial disorders have been blamed for muscle function degeneration as a result of agingu2010-related and obesityu2010. Exercise in High-u2010intensity interval training was shown to improve muscle and mitochondrial function in healthy young and old adults as well as obesity in obese older adults. Citrulline supplementation was also cited as a promising way to combat obesityu2010-related and agingu2010-related muscle dysfunction, according to new studies. Methods Eighty One phew a 2010b1-boed and obese participants underwent a 12 week HIIT, with or without CIT on an elliptical trainer [HIIT]: 18 men/18 women, 68. 1 years] [u00b1 4. 1 years] b1 4. 1 years]. Handgrip and quadriceps' durability, lower leg muscle strength, body composition, waist circumference, and functional capacities were tested pre and post intervention. Biopsies of subcutaneous abdominal adipose tissue biopsies were also performed to determine the expression of genes involved in lipid metabolism. Only HIITu2010CIT lost fat mass, increased handgrip, and quadriceps strength. CIDEA decreased the expression of the lipid droplet-u2010associated protein CIDEA by only HIITu2010CIT. Obese senior adults with high-intensity interval training is highly effective in increasing functional capacities, lean mass, muscle endurance, and waist circumference in obese older adults. In addition, HIIT also increases markers of mitochondrial biogenesis, mitochondrial fusion, and mitophagy. Importantly, adding CIT to HIIT results in a greater muscle endurance increase and a significant reduction in fat mass, as shown by the table below. According to the present report, HIIT mixed with CIT is an effective way to improve the health of obese older adults.

Source link: https://doi.org/10.1002/jcsm.12955


The association between skeletal muscle measures and chemotherapy‐induced toxicity in non‐small cell lung cancer patients

"Abstract Background Chemotherapy" is a term that refers to non-u2010small cell lung cancer patients treated with platinum-u2010-based chemotherapy. In a large population of NSCLC patients, the aim of this research was to determine the correlation between skeletal muscle measurements and chemotherapyu2010induced toxicity. In 36. 6% of the patients, 24. 6% of the patients, and 56% any DLT were involved in any non-u2010haematological toxicograde u22652 or 56%. No statistically significant relationships were found between low SMM or low SMD and non-u2010haematological toxicities in non-u2010haematological toxicities. Low SMM and high SMD were both statistically significant with a higher risk of DLT and lower risk of DLT. Conclusions Non-u2010small cell lung cancer patients with low SMM during pre-treatment are at a significant risk of haematological toxicities grade 3/4 and DLT. Patients with elevated SMD are at a significant risk of DLT in comparison to NSCLC patients with high SMD.

Source link: https://doi.org/10.1002/jcsm.12967


Targeting MuRF1 by small molecules in a HFpEF rat model improves myocardial diastolic function and skeletal muscle contractility

Background & Study About half of heart failure patients with preserved left ventricular function suffer from diastolic dysfunction. Small molecules interfered with MuRF1 target identification, thereby attenuating SKM myopathy and dysfunction in HFrEF animal models. MyoMedu2010205 elicited molecular changes in HFpEF and beyond. The aim of this research was to determine the sensitivity of one small molecule in HFpEF and to describe molecular shifts elicited by MyoMedu2010205. For 12 weeks, 2021-year-old female obese ZSF1 rats were given the MuRF1 inhibitor MyoMed U2010205; a comparison was made between age-matched untreated ZSF1 and obese rats as controls, as controls. SKM and endothelial functions were measured and tissues were collected for molecular analysis at week 32. To test MuRF1-u2010specificity, MuRF1 knockout mice SKM tissues were included in the study. Results By week 32, obese rats without treatment had normal LV ejection percentages, but the E/eu2032 ratios and increased end diastolic pressure and myocardial fibrosis were all typical features of HFpEF. In comparison, MyoMedu2010205 treated rats had markedly improved diastolic function, less myocardial fibrosis, reduced SKM myopathy, and increased SKM function. SKM extracts from MyoMedu2010205-treated rats had reduced MuRF1 content and reduced total muscle protein ubiquitination, which had decreased total muscle protein ubiquitination. The production of mitochondrial respiratory chain complexes I+ II in treated rats was consistent with MyoMed's target of u20205 205. SKM controls in MuRF1 and II had elevated mitochondrial complex I and II activities, as well as suggesting mitochondrial activity control by MuRF1. Conclusions Myomedu201205 enhanced myocardial diastolic function and reduced SKM atrophy/function in the ZSF1 animal model of HFpEF," according to MyoMed.

Source link: https://doi.org/10.1002/jcsm.12968

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions