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"Abstract Purpose: "Abstract Purpose: This report investigates the relationship between body composition change during concurrent chemoradiotherapy and outcome in patients with locally advanced cervical cancer. " Experimental Design: Pre- and Posttreatment CT images of 245 patients with LACC who were treated between 2004 and 2015 were analysed for experimental design. Two sets of CT images at the L3 vertebra were measured for Skeletal muscle thickness and density, subcutaneous adipose tissue index, and visceral adipose tissue index. However, SMI loss during CCRT of > 10. 0%/150 days was also attributed to lower OS and CSS when adjusted for FIGO stage, pathology, and treatment. Conclusions: Skeletal muscle testing may be imaging biomarkers to help patients with LACC in clinical practice. Further studies are required to determine whether multimodal interventions will preserve skeletal muscle mass and thus improve survival. ".
Source link: https://doi.org/10.1158/1078-0432.ccr-18-0788
"Abstract Fibroblast growth factor receptor receptors have been implicated in a slew of differing and proliferative activities. " We established a 214 bp promoter that served as a minimum promoter and investigated cis-DNA elements that were involved in the regulation of expression of the FGFR4 gene in these cells. Fragment C made specific complexes with nuclear extracts from both cell lines. Transfection of Sp1 but not Sp3 effectively stimulated FGFR4 promoter growth in the HS729-1015 cell line but not in the low FGFR4-expressing HS729-1016 cell line, an effect that was more apparent in the HS729-1015 cell line than in the low FGFR4-expressing HS729-1016 cell line. FGFR4 expression in cell lines and primary human rhabdomyosarcomas were linked to Sp1 protein expression in cell lines and primary human rhabdomyosarcomas, according to FGFR4 expression in cell lines and primary human rhabdomyosarcomas. Our results indicate Sp1 as a crucial player in FGFR4 expression in neoplasms derived from the same cell lineage, indicating a potential explanation for Sp1's heterogenous expression of FGFR4 in neoplasms derived from the same cell lineage.
Source link: https://doi.org/10.1158/1078-0432.ccr-04-0223
"Abstract Purpose: Severe muscle loss is linked to poor cancer outcomes, including reduced survival and increased toxicity. " This review looks at SM results in metastatic breast cancer patients receiving first-line taxane-based chemotherapy, as well as potential associations with treatment toxicity and other outcomes. Sarcopenia was defined as a skeletal muscle index u2264 41. By multiplying SMI u00d7 SMD, a Skeletal muscle gauge was created. In 57% of sarcopenic versus 18% of non-sarcopenic patients, toxicity was present in 57% of sarcopenic versus 18% of non-sarcopenic patients. Low SMG had a borderline significant relationship with any adverse event and overall survival despite the fact that the event was not a complete failure. Conclusions: MBC patients receiving first-line taxane-based chemotherapy are prone to toxic effects and survival. Further research is required to determine how routinely obtained CT scans can be used to personalize dosing and improve treatment planning.
Source link: https://doi.org/10.1158/1078-0432.ccr-16-0940
"Abstract Purpose: The mechanisms underlying muscle growth in cancer patients remain poorly understood, indicating that there is still a unsatisfied clinical need for new biomarkers and treatment strategies. " In single biopsies from healthy controls and in paired biopsies, the transcriptome was determined by microarrays in a single biopsy of patients with higher gastrointestinal cancer [pre-resection baseline and 8 month post-resection follow-up]. The expression in baseline muscle was seen in no literature-derived genes from preclinical cancer cachexia models. Despite the transcriptome's differences at baseline, the muscle of patients at follow-up was remarkably similar to control muscle, according to a comparison with healthy control muscle. Physical fitness did not differ between the baseline and follow-up periods, indicating that gene expression changes reflected the removal of the cancer rather than raising physical fitness levels," rather than changing physical activity levels.
Source link: https://doi.org/10.1158/1078-0432.ccr-11-2133
"Abstract Purpose" is a form of dietary data that can be used to determine the relationship between peripheral nerve stimulation and skeletal muscle magnetization transfer ratios. Methods were calculated based on manual segmentation of six representative slices, resulting in mean sciatic nerve MTR and high-resolution T2-weighted imaging of the sciatic nerve at 3 T. Mean sciatic nerve MTR and MTR of biceps femoris and vastus lateralis muscles. Muscle MTR was correlated with BMI and body mass, according to Muscle MTR. In the multiple linear regression model, the BMI was selected as the best predictor of mean muscle MTR. Conclusion With increasing age and BMI, peripheral nerve MTR decreases. Age and BMI implications should be considered in studies that evaluate peripheral nerve MTR. Skeletal muscle MTR is mainly linked to BMI, but it is less dependent on demographic variables. ".
Source link: https://doi.org/10.1007/s00062-021-01067-5
"Methods: Adipose and muscle tissue were measured by computed tomography at diagnosis and 50 to 120 days later in 164 patients with advanced pancreatic cancer. " Results: Compared to patients in the bottom quartile of muscle change per 30 days, those in the top quartile had a hazard ratio for death of 2. 01 [95% confidence interval, 1. 12]u20133. 62]. Patients in the top quartile of muscle attenuation change had a HR of 2. 19 compared to those in the bottom quartile. At diagnosis, elevated plasma branched chain amino acids and lower monocyte chemoattractant protein-1 were both correlated with greater future muscle loss. Conclusions: In patients with advanced pancreatic cancer, muscle loss, and decrease in muscle mass in 2 to 4 months after diagnosis, there was reduced survival. Impact: A high risk group for future tissue loss may be identified by BCAAs and MCP-1 levels at diagnosis may be a high-risk group for future tissue wasting. ".
Source link: https://doi.org/10.1158/1055-9965.epi-19-0370
"Our research outlined the expressions of St3gal, St6gal, and St6galltransferases specific to glycoproteins in mouse skeletal muscle and murine C2C12 myotubes. " The mRNAs of the St3gal family and St6galnac families of both experimental groups prevailed over the mRNA expressions of the St6gal and St6galnac families. In both experimental groups, the profiles of sialyltransferase expressions revealed differences between the two experimental groups, as shown by the absence of expressions of the mRNA for the St3gal6 and St6galnac3 genes in the C2C12 cell cultures and different proportions of the enzymes St3gal3 and St3gal4 genes in both experimental groups.
Source link: https://doi.org/10.14232/abs.2021.65.253-261
"Chicken is the most widely consumed meat product globally and is a high-quality protein source for humans. " ncRNAs play a vital role in the growth and development of muscle tissue in domestic chickens. Latest advances in sequencing technology have contributed to the identification and characterization of more ncRNAs involved in the production of domestic chicken skeletal muscle, where they play a major role in proliferation, differentiation, fusion, and apoptosis of myoblasts and satellite cells, as well as the determination of muscle fiber type. ".
Source link: https://doi.org/10.3390/genes13061033
"Abstract Background: The links between abdominal skeletal muscle mass index, visceral, and subcutaneous adipose tissue, and mortality among patients with stage I-u2013III colorectal cancer patients may vary for both men and women, but only few studies divided their results into men and women. We looked at studies involving abdominal SMI, VAT, and SAT in conjunction with overall mortality among men and women with stage Iu2013III colorectal cancer. The association of SMI and mortality in a nonlinear fashion in the RCS results was statistically significant among men, with lower SMI levels correlated with higher mortality among men. In a nonlinear way for both men and women, SAT was linked to mortality in a nonlinear manner, with lower SAT scores being correlated with increased mortality in a nonlinear fashion. Conclusion: The associations of abdominal skeletal muscle mass in patients with colorectal cancer were not the same for both men and women. ".
Source link: https://doi.org/10.1158/1055-9965.epi-19-1134
"Method Thirty-one male Sprague-Dawley rats were divided into four groups: surgical Sham; Denervated; and u03b22-agonist; and only agonist. The left masseteric nerve was visible in the surgical Sham group but not segmented. Formoterol was directly injected into the left masseter muscle every three days for eight weeks by the agonist. In three perspectives: lateral head, subordinate, and right and left disarticulated hemi-mandibles, sixteenteen angular and linear skeletal measurements were assessed in the overall craniofacial area and mandible by standardised digital radiography. Conclusions The results showed that following surgical denervation of the masseter muscle, there were dramatic changes in the muscle and subsequent bone growth. "Denervation atrophy of the masseter muscle fibers results in statistically significant changes in the underlying skeleton's construction. ".
Source link: https://doi.org/10.21307/aoj-2020-154
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