Advanced searches left 3/3

Skeletal Muscle - ClinicalTrials.gov

Summarized by Plex Scholar
Last Updated: 12 June 2022

* If you want to update the article please login/register

Involvement of Skeletal Muscle Fibrocytes in sarcOpenia in Patients With Chronic ObstRuctive bronchopneumopaThia

"Chronic obstructive pulmonary disease is a common and potentially severe chronic respiratory disease. " Cigar smoke exposure, which is responsible for 80% of cases, is the most dangerous risk factor. Sarcopenia is present in 4 to 66% of patients and is associated with a particularly acute patient profile, since patients with low muscle mass were three times higher than those with normal muscle mass. According to dexametry, a decrease in the appendicular muscle mass index measured by dexametry decreased to less than 7. 0 kg/m2 in males and 5. 5 kg/m2 in women, sarcopenia can be characterized as a decrease in sarcopenia. Several studies have referred to the histological changes in COPD patients, particularly in the quadriceps. These include a decrease in the diameter and vascularization of muscle fibers as a result of a change in fiber metabolism: the abandonment of type I fibers in favour of type II fibers. Fibrocytes are cells that are derived from blood monocytes and are able to migrate from the blood flow to different organs. Investigating their role in the formation of sarcopenia in COPD patients may therefore be a promising alternative given their ability to conceal pro-inflammatory factors and their potential influence on myofiber metabolism. Moreover, the migration of these cells into COPD patients' damaged tissues may be able to be accompanied by a therapeutic program by CXCR4 modulation due to their preferential recruitment via a CXCL12/CXCR4 chemotactic axis.

Source link: https://clinicaltrials.gov/ct2/show/NCT04939454


MusculRA: The Effects of Rheumatoid Arthritis on Skeletal Muscle Biomechanics

Healthy controls n=15 will be divided between two cohorts: 1 person with early RA n=15 and 2 age-, sex-, Body Mass Index BMI-matched healthy controls n=15. The duration of disease/symptoms of less than 6 months is assigned to Early RA, not the length of time since RA diagnosis or biologic DMARD therapy were chosen to minimize the effect of medications on skeletal muscle. Phone Pre-Screening: During an initial phone screening interview, demographics and comorbidities will be assessed by self-report, followed by electronic medical data. Participants will be sent a REDCap survey link to complete some online surveys regarding their general wellbeing, pain, physical function, sleep, and ability to cope with their disease after completion of the e-consent process. Two on-site study visits at the Duke Center for Living are included in the research; each visit lasts about 2. 5 hours. The following are sample test results from PROMIS SF v2. 0 Basic Health 5a Pain Intensity 3a PROMIS SF v1. 0 General Life Satisfaction 4a Stanford Brief Activity Survey Participants will participate in the following: Specifically, the following measures and versions are listed below: PROMIS SF v1. 0 Productivity Assurance ProMIS SF v1. 0 Physical Function The following tests will be administered at : PROMIS SF v2. 0 Global Health PROMIS SF v2. 0 Grip Strength Hand Dynamometer v2. 0 ProMIS : PROMIS v2. 0 Physical Function 20a ProMIS v2. 0 ProMIS & v1. 0 ProMIS a ProMIS v2. 0 Mobile v2. 0 ProMIS v2. 0 ProMIS v1. 0 B v2. 0 Physical Intens t 1. 0 Exercise Test v1. 0 ProMIS v2. 0 ProMIS v1. 0 Physical Function 20a Promise 5a PROMIS v2. 0 ProMIS 1. 0 ProMIS v1. 0 ProMIS v1. 0 v2. 0 ProMIS v1. 0 Physical Int v2. 0 The Following the following is a PROMIS v2. 0 ProMIS.

Source link: https://clinicaltrials.gov/ct2/show/NCT04226131


Effect of Sleep Restriction on Adipose Tissue and Skeletal Muscle Insulin Sensitivity

In vivo and ex vivo, the investigators will perform a controlled, cross-over trial to determine the effect of sleep restriction relative to normal sleep on adipose tissue and skeletal muscle insulin sensitivity. " Sleep restriction will reduce skeletal muscle and adipose tissue insulin sensitivity in comparison to normal sleep, according to the overarching theory.

Source link: https://clinicaltrials.gov/ct2/show/NCT04286451


Novel Molecular Mechanisms of Skeletal Muscle Insulin, Resistance if Physically Inactive Older Adults

"The investigator team will recruit younger and older male and female adults in the Salt Lake City area. " These tests will take place within a week before the reduced activity trial was completed and after exercise conditioning. A Nottingham power rig will be used for lower extremity extension power testing. During a graded maximal endurance test on a stationary cycle ergometer, maximum oxygen consumption will be determined by a metabolic cart. Subjects will be fitted with an ankle Step Activity Monitor in order to determine their daily physical fitness level over a 7-day period before the reduced physical activity survey was conducted. The insulin infusion period will determine the glucose concentration 30 minutes before the start of the insulin infusion and 30 minutes at the end of the insulin infusion period. A vastus lateralis muscle biopsy will be performed before and 3h after the clamp, as well as periodic blood testing for measure of fasting and insulin-stimulated insulin, glucose, muscle cell signaling endpoints, and specific ceramide species. As we have done routinely in our bed rest studies in older adults, trained CCTS nurses were able to do biopsies in our bed rest studies in older adults. The participant's home will begin with the reduced physical inactivity study, which will follow the clamp experiment. Following an overnight fast, the participant will return to the CCTS following an overnight fast, and the insulin clamp trial will be repeated on Day 14 in order to make comparisons to the pre insulin clamp experiment. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT02971098


The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older Adults

"Type 2 diabetes can cause acute muscle atrophy and recovery from disuse, but it has not been investigated. " Following bed rest, the primary objectives of this research are to use novel techniques in muscle biopsy samples in order to decipher mitochondrial dysfunction and lipotoxicity in older adults with pre-diabetes and type 2 diabetes in order to decipher the temporal sequence by which mitochondrial dysfunction and metabolic dysfunction contribute to muscular atrophy and recovery of muscle mass, strength, and physical function. The strict bedrest will be followed by four weeks of ambulatory recovery for senior adults with and without pre-diabetes/type 2 diabetes.

Source link: https://clinicaltrials.gov/ct2/show/NCT03761446


SPECT/CT Imaging of Skeletal Muscle Perfusion in Healthy Control Subjects and Patients With Peripheral Arterial Disease: Pilot Clinical Study

"Healthy control students will be recruited from Yale University and the greater New Haven area. " Patients undergoing revascularization therapy will be identified and encouraged to participate in the imaging study prior to their revascularization procedure and imaged once more 1-3 days following revascularization, prior to hospital discharge. In healthy control subjects, arterial blood will be collected continuously from the radial artery for determination of a blood pressure function and K1 values for foot angiosomes. Moreover, we will collect heated venous blood from a hand vein retrograde to determine the potential for heated venous blood in the calculation of a blood donation function, thus eliminating the need for arterial access in future PAD patient studies. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT02791204


Pilot Study to Assess Biomarkers of Changes in Barrier Function of Skeletal Muscle in Patients With a Fragile Sarcolemmal Muscular Dystrophy

"Objectives: the aim of this research is to determine biomarker and clinical correlates of changes in the barrier function of skeletal muscle membrane before and after routine motor function testing in patients with one of the Fragile Sarcolemmal Muscular Dystrophies. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT01851447


Effect of Incorporating Lean Beef Into a Protein-rich Diet During Resistance Training Program on Skeletal Muscle and Connective Tissue Strength and Quality in Older Women

"Skeletal muscle endurance and mobility are also dependent on the fabric and mechanical properties of connective tissue, which encase skeletal muscle, allowing for effective transfer of tension during cross-bridge cycling. " Importantly, skeletal muscle mass and function are directly related to connective tissue strength. As with skeletal muscle, aging leads to tendon connective tissue quality degradation, including reductions in tendon collagen and a decrease in tendon CSA. According to previous studies, resistance training can increase muscle mass and strength in older adults, but will not reduce the effects of aging on tendon. No products are available that address both skeletal muscle and tendon health to avoid muscle mass and quality loss, while simultaneously improving connective tissue integrity and function in older adults. However, limited research has been done on the effect of beef intake and RT on sarcopenia-related outcomes, particularly in older women. In older women, this report will determine the consequences of consuming a healthy, protein-rich diet emphasizing lean beef on RT-induced changes in skeletal muscle and tendon connective tissue size, strength, and quality. When compared to eating a healthy diet with standard or high-protein and less total red meat, it is hypothesized that intake of a high protein diet from predominately lean beef would increase both skeletal muscle and tendon responses to RT.

Source link: https://clinicaltrials.gov/ct2/show/NCT04347447

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions