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"The use of minimally invasive technologies to enable the testing of tissue permittivity in the neuromuscular clinic remains elusive. " Compared to conventional electrical impedance-based needle technologies that we have developed, the new needle shape and numerical methods used enable estimation of vivo muscle permittivity values with just a single needle insert. With a single needle insertion, you'll be able to monitor muscle permistivity directly, opening up a whole new field of study with direct clinical use, including using these results to aid in neuromuscular diagnosis and to determine subtle effects of therapeutic intervention on muscle health.
"Despite the fact that blood and lymphatic vessels within the endomysial and perimysial chambers undergo significant changes in diameter and length during stretch and contraction, skeletal muscle is widely believed to be almost incompressible. " Using results from the rat spinotrapezius muscle, we can also quantify the distribution of blood and initial lymphatic vessels within a fascicle and its perimysial space. For a 20% decrease and stretch, respectively, the model estimates that the blood volume in the endomysial space will rises 24% and decreases 22%. "This means that arcade blood vessels in the perimysial space are the primary pumping action required for IL filling and emptying during muscular contraction and stretch. ".
"Engineered living systems is a quickly expanding field in which functional biohybrid machines are being built by the mixing of cells or tissues with engineered scaffolds for countless industrial applications. " "pump-bot," a biohybrid pumping unit capable of producing unidirectional flow aided by engineered skeletal muscle tissue, is shown here.
"Preclinical biomedical and pharmaceutical research on disease causes, drug targets, and side effects is increasingly dependent on in vitro human tissue models. " Unique opportunities for designing models of superior physiological fidelity, as well as automating their manufacturing are available with 3D printing. We here outline a simple and scalable method for creating physiologically relevant models of skeletal muscle for these purposes. Our approach is based on a two-material micro-extrusion of two types of gelatin hydrogel into patterned soft substrates with locally alternating stiffness. The fabricated myotubes can be made in a simple and reproducible manner, and various myotube designs can be made in a few millimeters.
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