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To produce a rapid high-u2010performance liquid chromatography method for simultaneous estimation of simvastatin and fenofibrate in a present study by design, we used an innovative high-quality by design. In addition, a quantitative correlation between critical material attributes and CQA was established using Box-u2010Behnken's design to produce analytical design space and implement a control system. As an optimized mobile phase with a flow rate of 0. 99 ml/min, the most effective and expected conditions were acetonitrile and potassium dihydrogen orthophosphate buffer as an optimized mobile phase. As a result, a simple, accurate, and repeatable high-u2010performance liquid chromatography method for routine quality control testing was developed.
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