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Simvastatin - Wiley Online Library

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Last Updated: 09 September 2022

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Quality by design assisted high‐performance liquid chromatography parameters for simultaneous estimation of simvastatin and fenofibrate

To produce a rapid high-u2010performance liquid chromatography method for simultaneous estimation of simvastatin and fenofibrate in a present study by design, we used an innovative high-quality by design. In addition, a quantitative correlation between critical material attributes and CQA was established using Box-u2010Behnken's design to produce analytical design space and implement a control system. As an optimized mobile phase with a flow rate of 0. 99 ml/min, the most effective and expected conditions were acetonitrile and potassium dihydrogen orthophosphate buffer as an optimized mobile phase. As a result, a simple, accurate, and repeatable high-u2010performance liquid chromatography method for routine quality control testing was developed.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/sscp.202200078

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions