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Simvastatin - PubMed

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Last Updated: 09 September 2022

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Simvastatin-hydroxyapatite coatings prevent biofilm formation and improve bone formation in implant-associated infections.

Implant-associated infections caused by biofilm formation are the most common problems of orthopedic surgery. Statins have been commonly and safely used for hypercholesterolemia for many years. In vitro, crystal violet staining and live-dead bacterial staining revealed the antibacterial activity of simvastatin against Staphylococcus epidermidis biofilms. Staphylococcus aureus biofilm production was stifled and improved the titanium alloy's biocompatibility, according to the Sim-HA coatings. As shown by radiological analysis and histological testing, Sim-HA coatings effectively blocked Staphylococcus autus IAI in rat femurs. In summary, Sim-HA coatings are promising implant materials for protection against biofilm-associated infections.

Source link: https://doi.org/10.1016/j.bioactmat.2022.07.028


Simvastatin Loaded Dissolvable Microneedle Patches with Improved Pharmacokinetic Performance.

Microneedle patches are one of the latest drug delivery methods that involve minimal disruption and increased skin penetration of macro- and micro-entities. We present dissolvable microneedle patches as a novel device for increased systemic delivery of Simvastatin in hypocholesterolemia prevention. Based on the regression coefficient, Kinetic modelling demonstrated zero order as the best fit model based on regression coefficient.

Source link: https://doi.org/10.3390/mi13081304


Anabolic Effects of a Novel Simvastatin Derivative on Treating Rat Bone Defects.

We hypothesize that KMUHC-01 may help bone formation in bone-defect animal models. We used rat models of significant calvarial and long-bone defects to determine the effects of KMUHC-01 and simvastatin on biological changes at the bone defect, immunohistology, and mechanical testing, as well as determining the new bone microstructure by microcomputed tomography analysis. In the control and simvastatin groups, the newly developed bone microstructure at the calvarial defect site had a significantly raised trabecular bone volume in the KMUHC-011-u03bcM group compared to those in the control and simvastatin groups.

Source link: https://doi.org/10.3390/biomedicines10081915


Metabolite Signature of Simvastatin Treatment Involves Multiple Metabolic Pathways.

Only a small number of metabolites were found in previous studies examining the metabolite signature of simvastatin therapy. A high-throughput liquid chromatography-tandem mass spectroscopy profiling of simvastatin therapy in the METSIM study, which included 1332 participants with simvastatin therapy and 6200 without statin therapy, was conducted on 1098 metabolite concentrations in the participants, including 1332 participants with simvastatin therapy and 6200 controls without statin therapy. In a large population-based study, our research is the first comprehensive review of simvastatin therapy's metabolic signature.

Source link: https://doi.org/10.3390/metabo12080753


Preparing simvastatin nanoparticles by a combination of pH-sensitive and timed-release approaches for the potential treatment of ulcerative colitis.

In this research, an emulsion solvent evaporation process was used to produce Eudragit RL nanoparticles containing simvastatin for ulcerative colitis therapy. Using the Box-Behnken system, the effects of various formulation variables on NPs' characteristics were investigated. Colitis was caused by 3% of acetic acid in rats, which obtained NPs of SIM, mesalazine, blank NPs, and normal saline orally for five days. With EFS30D, Coating the optimized NPs resulted in an increase in particle size and a decrease in the zeta potential of NPs. In addition, MPO usage and MDA were significantly reduced by NPs as compared to the control group.

Source link: https://doi.org/10.1177/08853282221122907


Effect of Simvastatin and Low-Level Laser Therapy on Sutural Bone Formation After Expansion in Rats: Biomechanical, Computed Tomography and Immunohistochemical Assessment.

Introduction: In rapid palatal expansion, bone formation has been accelerated by the use of low-level laser therapy and some drugs. This research was conducted to determine the effects of simvastatin and LLLT alone and combined on rats' sutural bone formation. Sixty male Wistar rats averagely weighing 150 grams were divided into five groups of control : 5 mg simvastatin, 10 mg simvastatin, LLLT, and LLLT plus 10 mg simvastatin. Results: Groups 3 and 4 showed a significant rise in osteogenesis compared to the control group. In terms of all parameters, Group 5 was notably superior to all other groups. Conclusion: Although LLLT, simvastatin therapy, and a combination of both dramatically enhanced sutural bone formation in rats compared to the control group, the combined therapy produced significantly higher clinical outcomes compared to other interventions.

Source link: https://doi.org/10.34172/jlms.2022.21


Simvastatin Inhibits Brucella abortus Invasion into RAW 264.7 Cells through Suppression of the Mevalonate Pathway and Promotes Host Immunity during Infection in a Mouse Model.

In this research, we investigate the effects of simvastatin treatment on RAW 264. 7 macrophage cells and ICR mice against Brucella abortus infections. Notably, the inhibitory effect of simvastatin therapy on Brucella's Brucella invasion was not dependent on cholesterol reduction but rather on the decline of farnesyl pyrophosphate and geranyl pyrophosphate synthesis. These results showed the presence of the mevalonate pathway in B. abortus phagocytosis in RAW 264. 7 macrophage cells and the control of simvastatin on the host immune system against Brucella infections.

Source link: https://doi.org/10.3390/ijms23158337

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions