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Simvastatin - OSTI GOV

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Last Updated: 09 June 2022

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Simvastatin mitigates increases in risk factors for and the occurrence of cardiac disease following 10 Gy total body irradiation

After a 10 Gy total body irradiation was established, it was determined that simvastatin's ability to reduce the rises in risk factors for and the occurrence of cardiac disease. " Male rats were given a single dose TBI of ten Gy. TBI results in cell peri-arterial fibrosis in the isolated heart, while control hearts had less collagen and fibrosis. Simvastatin alleviated cardiac mechanical disruption 20–u2013120 days after TBI. In vitro, it was determined that simvastatin helps the heart to withstand stress after TBI. TBI exacerbated an induced myocardial infarction in 20 and 80 days after irradiation, which was painful. Simvastatin lessened the impact of this myocardial infarction at 20 and 80 days following TBI. Following TBI, simvastatin has reduced the risk factors for cardiac disease and cardiac disease incidence.

Source link: https://www.osti.gov/biblio/1213431

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions