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Simvastatin - Europe PMC

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Last Updated: 09 September 2022

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Anti-inflammatory effect of simvastatin by impeding TNF-α and interleukin-1ß pathways: antiangiogenic activity of simvastatin and simvastatin-loaded silver nanoparticles.

Purpose The present research was conducted to determine the anti-inflammatory and antiangiogenic characteristics of simvastatin and its nanofilms containing silver nanoparticles. Silver nanoparticles and simvastatin-loaded nanocomposite films were created by using a polymeric solution with a casting solution technique. In addition, chick chorioallantoic membrane assay was also used for angiogenesis activity. In F9 film thermogram, there was no endothermic reaction. The results of a large dose of simvastatin and indomethacin in a cotton-pellet induced granuloma model study showed similar anti-inflammatory activity. While the findings of CAM assay demonstrated remarkable anti-angiogenic activity of SNSN films depicting dissolved blood vessels network macroscopically,.

Source link: https://europepmc.org/article/MED/35866995


Local simvastatin and inflammation during periodontal mini-flap wound healing: Exploratory results.

Background of the study The aim of this exploratory research was to determine inflammatory markers in periodontal maintenance patients from a double-masked, parallel intervention clinical trial comparing local simvastatin to carrier alone following mini-flap access. Methods Five patients with a 6-9 mm inflamed pocket during periodontal maintenance therapy were treated with papilla reflection/root planing and the delivery of 2. 2 mg simvastatin in methylcellulose or methylcellulose alone. Associations between inflammatory markers and 12-month results were used in Wilcoxon Rank Sum tests or Pearson correlations. Patients in the SIM group had 4. 8 percent higher chances of improved BOP at 12 months, according to the study. After two weeks of recovery, median IL-6 and VEGF were much elevated for both patients, while median IL-10 gene activation was increased after 2 weeks in SIM/MCL. Overall, elevated GCF IL-10 at 2 weeks was highly correlated with improved CAL at 12 months.

Source link: https://europepmc.org/article/MED/36017934


Preparing simvastatin nanoparticles by a combination of pH-sensitive and timed-release approaches for the potential treatment of ulcerative colitis.

This research used an emulsion solvent evaporation technique to produce Eudragit RL nanoparticles coated with simvastatin for the treatment of ulcerative colitis. Using the Box-Behnken method, the effects of various formulation variables on NPs' characteristics were investigated. In different physiological environments, drug release was investigated. Colitis was triggered by 3% of acetic acid in rats, which subsequently received NPs of SIM, mesalazine, blank NPs, and normal saline orally for 5 days. With EFS30D, Coating optimized NPs resulted in an increase in particle size and a decrease in the zeta potential of NPs. In addition, MPO satisfaction and MDA level were greatly reduced by NPs, relative to the control group. Hence, this drug delivery method may be a better alternative to UC's previous treatments.

Source link: https://europepmc.org/article/MED/35999010


Metabolite Signature of Simvastatin Treatment Involves Multiple Metabolic Pathways.

Only a small number of metabolites were found in previous research on the metabolite signature of simvastatin therapy. 732 participants with simvastatin treatment and 6200 without statin therapy were included in a high-throughput liquid chromatography-tandem mass spectroscopy profiling study on the effects of simvastatin therapy on 1098 metabolite concentrations in the METSIM study's participants, including 1332 participants with simvastatin treatment and 6200 participants without statin therapy. In a large population-based analysis, our study is the first comprehensive review of simvastatin treatment's metabolic signature.

Source link: https://europepmc.org/article/MED/36005625


Simvastatin-hydroxyapatite coatings prevent biofilm formation and improve bone formation in implant-associated infections.

The most difficult problems of orthopedic surgery are implant-associated infections caused by biofilm formation. Statins have been commonly and safely used for hypercholesterolemia for many years. Staphylococcus aureus and Staphylococcus epidermidis biofilms in vitro were demonstrated by crystal violet staining and live-dead bacterial staining. Staphylococcus aureus biofilm production and enhanced the titanium alloy's biocompatibility were inhibited by Sim-HA coatings, which also increased the biocompatibility of the titanium alloy. As shown by radiological analysis and histological examination, Sim-HA coatings effectively stopped Staphylococcus autus IAI in rats femurs.

Source link: https://europepmc.org/article/MED/36017072


Simvastatin Loaded Dissolvable Microneedle Patches with Improved Pharmacokinetic Performance.

Microneedle patches are one of the latest drug delivery techniques involving minimal invasion and improved skin penetration of macro- and micro-entities. We present dissolvable microneedle patches as a novel device for improving systemic delivery of Simvastatin in the treatment of hypocholesteemia. Based on regression coefficient, Kinetic modelling identified zero order as the best fit model based on regression coefficient.

Source link: https://europepmc.org/article/MED/36014226

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions