Advanced searches left 3/3

Simvastatin - DOAJ

Summarized by Plex Scholar
Last Updated: 09 September 2022

* If you want to update the article please login/register

Experimental study on the effects of simvastatin in reversing the femoral metaphyseal defects induced by sodium valproate in normal and ovariectomized rats

The present research looked at the role of simvastatin in reversing bone defect healing in normal and ovariectomized rats. In comparison to the SVP plus SIM therapy group, results: Micro-CT, biomechanical, and histological evaluations revealed lower bone strength and delayed bone healing in the SVP therapy group and delayed bone healing. OVX's bone loss was exacerbated by the drug OVX, but in the OVX rats, the effect of SIM in ameliorating bone loss was even more apparent. Conclusions: In rats treated with SVP therapy, especially the OVX SVP treatment group, lower bone density and delayed bone repair were shown by this research. On the contrary, SIM-based therapy was highly effective in bone growth and bone defect repair, as well as promoting bone repair and inhibiting osteogenesis and osteoclastogenesis.

Source link: https://doi.org/10.1016/j.heliyon.2022.e10480


Hyaluronic Acid-Functionalized Mesoporous Silica Nanoparticles Loading Simvastatin for Targeted Therapy of Atherosclerosis

We created an enzyme-responsive and macrophage-targeted drug delivery device that could help to regulate the microenvironment of the atherosclerotic plaques that are characterized by increased inflammation and overexpression of hyaluronidase for precise AS therapy. More specifically, mesoporous silica nanoparticles were loaded with a lipid-lowering agent simvastatin and then gated with a hyaluronic acid coating, which gave the nanosystem increased sensitivity and sensitivity to inflammatory macrophages. Our results revealed that silica-based nanocarriers were able to simultaneously achieve high loading efficiency and excellent enzyme-responsive delivery of SIM for the first time by silica-based nanocarriers through formulation optimizations.

Source link: https://doi.org/10.3390/pharmaceutics14061265


Salmonella Enteritidis Subunit Vaccine Candidate Based on SseB Protein Co-Delivered with Simvastatin as Adjuvant

Salmonella enterica serovar Enteritidis, a common zooonotic pathogen that can cause diarrhea and systemic infections in humans and animals, as well as mortality in animals. Subunit vaccines are safe and provide targeted defense against Salmonella spp. S SseB gene from S is amplified by We amplified the SseB gene from S. With antisera against Salmonella Enteritidis C50041, Western blotting confirmed the immunoreactivity of recombinant proteins rHis-SseB and rGST-SseB. Both the SseB-specific antibody titer in serum and splenic lymphocyte proliferation in a mouse model of intramuscular vaccination, co-immunization with rHis-SseB and simvastatin significantly improved both the SseB-specific antibody titer in serum and splenic lymphocyte proliferation, according to a mouse model of intramuscular vaccination. Enteritidis C50041 strain is responsible for reduced bacterial colonization in the liver and spleen.

Source link: https://doi.org/10.3390/pathogens11040443


Dry Powder Formulation of Simvastatin Nanoparticles for Potential Application in Pulmonary Arterial Hypertension

It has been speculated that simvastatin could be used to treat pulmonary arterial hypertension. This research is intended to produce a simvastatin nanoparticle dry powder inhalation system. Simvastatin nanoparticles were manufactured by an emulsification and homogenization process, followed by spray drying of the colloidal suspension of simvastatin nanoparticles containing mannitol to bring it to a respirable size. The DPI formulation's aerosolization results of the DPI formulation was evaluated by the Next Generation Impactor, which is equipped with an Aerolizer u00ae. The crystallinity of simvastatin was reduced by the spray drying process, according to the X-ray diffraction study. In conclusion, the results showed that the spray drying procedure for simvastatin can be optimized to produce simvastatin aggregated nanoparticles without any coarse carrier, which can be used in DPI formulation for improved deposition of the drug in the lungs for local treatment of PAH in the lungs.

Source link: https://doi.org/10.3390/pharmaceutics14050895


A Fast and Validated Reversed-Phase HPLC Method for Simultaneous Determination of Simvastatin, Atorvastatin, Telmisartan and Irbesartan in Bulk Drugs and Tablet Formulations

The aim of this research was to develop and validate a fast and simple reversed-phase HPLC method for simultaneous determination of four cardiovascular agents such as u2014, simvastatin, telmisartan, and irbesartan in bulk pharmaceutical and tablet oral dosage forms. a ratio of 40:60 vs. v. vs. v. The chromatographic separation was achieved by using a Symmetry C18 column with a mobile phase consisting of ammonium acetate buffer and acetonitrile in a ratio of 40:60 vs. v. vs. v. a The new technique has been used to quantify all four medications in their tablet dosage forms, with a rate recovery within 100 percent below 100 %.

Source link: https://doi.org/10.3390/scipharm86010001


Effect of Pravastatin and Simvastatin on the Reduction of Cytochrome C

With an O2 electrode, glutathione was used as a respiratory substrate to determine the mitochondrial oxygen consumption of rat liver. Pravastatin reduces cytochrome c and oxygen consumption of the mitochondria, while simvastatin, on the other hand, raises the reduction of cytochrome c and mitochondrial oxygen consumption. Simvastatin can directly influence mitochondrial oxygen consumption by increasing oxidizing stress and thus facilitating apoptosis, according to the study.

Source link: https://doi.org/10.3390/jpm12071121


The Enhanced Cytotoxic and Pro-Apoptotic Effects of Optimized Simvastatin-Loaded Emulsomes on MCF-7 Breast Cancer Cells

Statins, including simvastatin, are often used for hyperlipidaemia control, and they also have demonstrated therapeutic and preventative effects in cardiovascular diseases. In this research, SMV-loaded emulsomes were formulated and tested for their cytotoxic activity in MCF-7 breast cancer cells. The impact of formulation conditions on vesicle size and drug entrapment was studied by a Box-u2013Behnken model. The optimized SMV-EMLs formulation had a significantly lower half maximal inhibitory concentration against MCF-7 cells, according to a study of cytotoxic reactions. Cell-cycle analysis revealed the proliferation of cells in the G2-M phase as well as increased cell fraction in the pre-G1 phase, suggesting an increase in SMV's anti-apoptotic activity. Annex V cellular content increased in early and late apoptosis, which was consistent with the increased cellular content of caspase-3 and Bax. SMV-EMLs had superior cell death-inducing activity against MCF-7 cells in comparison to pure SMV.

Source link: https://doi.org/10.3390/pharmaceutics12070597


Co-Amorphous Formation of Simvastatin-Ezetimibe: Enhanced Physical Stability, Bioavailability and Cholesterol-Lowering Effects in LDLr−/−Mice

Hypercholesterolemia is one of the key risk factors for cardiovascular disease development, particularly atherosclerosis. The SIM-EZE CO or PM was first introduced by oral gavage, and mouse blood samples were collected retro-orbitally at various time points to determine plasma drug concentrations. We investigated the limitation of CO on mouse plasma lipid levels using PM as a test. In addition, the effect of EZE on the NPC1L1 mRNA expression level in the mouse intestines was also investigated. SIM-EZE CO significantly increased the cholesterol-lowering effects of the medications in comparison to their PM, according to pharmacodynamic studies. After being offered the SIM-EZE CO, the mouse intestines had more feces and inhibitory effect on NCP1L1 gene expression in the mouse intestines.

Source link: https://doi.org/10.3390/pharmaceutics14061258


Merging Experimental Design and Nanotechnology for the Development of Optimized Simvastatin Spanlastics: A Promising Combined Strategy for Augmenting the Suppression of Various Human Cancer Cells

Simvastatin, an antihyperlipidemic drug that has been tested as a potential anti-cancer agent, is a registered antihyperlipidemic agent. The delivery of adequate doses to the cancer cells is the key to successful malignant tumor therapy using drugs, as well as minimizing side effects following their systemic administration. Our research sought to find out the possibility of a blended mixture/u2013process variable design for enhancement of SMV spanlastics with minimized particle size and increased zeta potential to improve the drug's anticancer sensitivity. Responses revealed that the study examined the effects of Span 20 and Tween 80 as mixture components and sonication time as a process variable on particle size, polydispersity index, and zeta potential as responses. For the three responses, the percentage relative error between predicted responses and the observed ones was less than 5%, showing the optimization technique's credibility.

Source link: https://doi.org/10.3390/pharmaceutics14051024


Preformulation Studies of Ezetimibe-Simvastatin Solid Dispersions in the Development of Fixed-Dose Combinations

The phase composition analysis was carried out using the co-grinding technique in a variety of weight fractions and differential scanning calorimetry and X-ray powder diffraction. A simple eutectic phase equilibrium diagram was found by DSC researchers, simvastatin and ezetimibe's phase equilibrium diagram. The results obtained in our studies provide an opportunity for the design of well-formulated, ezetimibe-simvastatin fixed-dose combinations with reduced ezetimibe dosages based on dissolution improvement.

Source link: https://doi.org/10.3390/pharmaceutics14050912

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions