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Leucocytes and platelets are both inflammatory anaemia and secondary activation of leucocytes and platelets, which can in turn contribute to haemolysis. In anakinra-treated mice compared to vehicle-treated mice, haemolysis markers were reduced within 2 weeks of therapy. Blood from anakinra-treated mice was less vulnerable to ex vivo erythrocyte sickling and was non-specific IL-1-mediated sickling, which was also resistant to exogenous IL-1-mediated sickling. The IL-1-treated platelet solution was sufficient to induce erythrocyte sickling, an effect not observed with platelet supernatant obtained from IL-1R-/- mice. In conclusion, pharmacological IL-1R antagonism promotes elevated anaemia in a murine SCD model.
Source link: https://doi.org/10.1111/bjh.17941
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