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Sickle Cell Disease - U.S. Department of Veterans Affairs

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Last Updated: 12 March 2022

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Interleukin-1 receptor antagonism leads to improved anaemia in a murine model of sickle cell disease and is associated with reduced ex vivo platelet-mediated erythrocyte sickling.

Leucocytes and platelets are both inflammatory anaemia and secondary activation of leucocytes and platelets, which can in turn contribute to haemolysis. In anakinra-treated mice compared to vehicle-treated mice, haemolysis markers were reduced within 2 weeks of therapy. Blood from anakinra-treated mice was less vulnerable to ex vivo erythrocyte sickling and was non-specific IL-1-mediated sickling, which was also resistant to exogenous IL-1-mediated sickling. The IL-1-treated platelet solution was sufficient to induce erythrocyte sickling, an effect not observed with platelet supernatant obtained from IL-1R-/- mice. In conclusion, pharmacological IL-1R antagonism promotes elevated anaemia in a murine SCD model.

Source link: https://doi.org/10.1111/bjh.17941

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions