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Multiple kidney abnormalities have been found with sickle cell disease and sickle cell disease. " With age, young adults with SCD have elevated effective renal plasma flow and glomerular filtration rates, which have declined to normal ranges in young adulthood and subnormal filtration rates. Kidney function in individuals with SCD is declining more quickly than in those with sickle cell trait or healthy people. Adults with SCD have elevated mortality, and chronic kidney disease and rapid decrease in estimated glomerular filtration rate. Multiple trials of novel therapeutic agents are ongoing, and kidney disease sufferers with SCD and kidney disease should be screened for kidney transplantation. Patients with sickle cell disease sufferer hemoglobinuria is common in patients with sickle cell disease and anticipates the development of chronic kidney disease. In patients with sickle cell disorder and SCD, Haematuria is usually benign, but it may be a presenting sign of renal medullary carcinoma. Kidney function is declining faster in individuals with sickle cell disease and SCD than in the general African American population; baseline CKD and rapid decline in estimated glomerular filtration rate are both associated with increased mortality in SCD. Sickle cell disorders and sickle cell nephropathy are associated with kidney abnormalities and sickle cell nephropathy. "The authors discuss the pathological changes in the kidney and their underlying mechanisms, as well as the detection, treatment, and management of kidney disease in patients with sickle cell syndromes. ".
Source link: https://doi.org/10.1038/s41581-022-00540-9
"Caregivers of children with sickle cell disease experience significant physical and emotional difficulties with their child's disease management. " Little is known about the potential contributors to parenting anxiety in pediatric SCD. After accounting for parent depression and anxiety, parenting stress also showed the connection between child pain frequency and healthcare utilization. Parenting anxiety may play a unique and crucial role in pediatric SCD, as well as the effects that parenting stress can have on children in medical and academic settings. ".
Source link: https://doi.org/10.1007/s10880-021-09837-6
"Background Congenital absence of the internal carotid artery is a highly rare congenital disorder that affects less than 0. 05 percent of the population; bilateral absence is extremely unusual, with symptoms of bilateral absence exceedingly low in the ICA despite unilateral absence of the ICA. " Case study We present a five-year-old boy with SCD who had an ischemic stroke episode with epileptic seizures following an ischemic stroke event. "Sickle cell disease has a high risk of stroke. ".
Source link: https://doi.org/10.1186/s12883-022-02702-5
"L-glutamine has been tested for its therapeutic ability to reduce VOC" due to elevated levels of oxidative stress and a decreased : ratio in sickle erythrocytes that adversely affects the blood rheology and lower : ratio in sickle erythrocytes that adversely influence the blood rheology and low : ratio in healthy red blood cells. Although L-glutamine was approved by the U. S. Food and Drug Administration to treat SCD, the effect on sickle erythrocytes in a redox environment is not fully understood. The mechanism by which L-glutamine reduces SCD's VOC is also unclear. We'll review the findings of the Phase 3 research that led to the approval of L-glutamine for treating SCD and addressing the assumed mechanisms of action in this paper. We'll investigate L-glutamine in health and then explore how the extra-erythrocytic functions of L-glutamine may have contributed to its beneficial effects in SCD. ".
Source link: https://doi.org/10.1007/s00277-022-04867-y
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