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Sickle Cell Disease - PLOS

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Last Updated: 12 June 2022

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Salubrinal induces fetal hemoglobin expression via the stress-signaling pathway in human sickle erythroid progenitors and sickle cell disease mice

"Sickle cell disease is an inherited blood disorder characterized by a mutation in the HBB gene leading to hemoglobin S production and polymerization under hypoxia conditions that result in vaping, persistent hemolysis, and progressive organ damage. " A 1. 4-fold rise in reactive oxygen species in Sickle erythroid progenitors treated with 24. u03bcM SAL increased F-cell counts by 1. 4 percent and resulted in an 80% decrease in reactive oxygen species. Peak plasma concentrations were obtained at 6 hours following subsequent treatment of SCD mice by a single intraperitoneal injection of SAL. A 2. 3-fold rise in F-cells and reduced sickle erythrocytes supporting in vivo HbF induction is related to chronic SCD mice with SAL.

Source link: https://doi.org/10.1371/journal.pone.0261799

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions