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"Sickle cell disease is a group of disorders affecting hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. " People with the disease have a characteristic hemoglobin S, which can distort red blood cells into a sickle or crescent shape. The sickling of red blood cells is responsible for sickle cell disease's signs and symptoms. The rapid depletion of red blood cells may also result in yellowing of the eyes and skin, which are indications of jaundice. When sickled red blood cells, which are rigid and inflexible, become trapped in small blood vessels, painful episodes can occur. High blood pressure in the blood vessels that supply the lungs contributes to heart failure, which can lead to heart failure. About 10% of adults with sickle cell disease have hypertension, according to Pulmonary hypertension.
"Moyamoya disease is a disorder of blood vessels in the brain, especially the internal carotid arteries and the arteries that branch from them. " Blood flow in the brain is reduced by narrowing these vessels. Moyamoya disease is common in young children or in older people's thirties or forties. In addition, the fragile blood vessels that grow can bulge or crack open, resulting in bleeding in the brain. People affected by recurrent headaches, compulsory jerking attempts, or a decrease in thinking capacity may result. If the condition is not addressed, the symptoms of moyamoya disease can often exacerbate over time. Some people have the blood vessel changes typical of moyamoya disease in comparison to those of another disorder, such as neurofibromatosis type 1, sickle cell disease, or Graves disease, are among those with this disorder. These people are thought to have moyamoya syndrome.
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