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Sickle Cell Disease - Astrophysics Data System

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Last Updated: 12 June 2022

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Optical absorbance-based rapid test for the detection of sickle cell trait and sickle cell disease at the point-of-care

"People with sickle cell disease experience severe decline in quality of life. " Extensive and accurate testing of individuals with sickle cell trait in the population can be helpful in preventing disease propagation, as well as genetic counseling can reduce disease transmission. Mass screening is usually carried out using the solubility test, which does not provide high specificity. SCD and SCT can be quickly and accurately diagnosed and identifying SCD and SCT using this research. Both phases of the investigation revealed that a total of 438 patient samples were tested using the new protocol. The proposed test has the ability to obliviate the current two-step screening and diagnostic procedure, as it can be used at the point-of-care with little training and yet yield results good enough to verify disability benefit claims.

Source link: https://ui.adsabs.harvard.edu/abs/2022AcSpA.27921394S/abstract


Simultaneous polymerization and adhesion under hypoxia in sickle cell disease

"Patients with sickle cell disease suffer from traumatic vaping crises. " We know that the age of RBCs in circulation plays a significant role in mediating this synergistic effect on blood rheology and clinical symptoms. In particular, the youngest RBCs have peculiar adhesion dynamics, with polymerized HbS fiber bundles growing from cell surfaces to serve as sites of cytoadherence.

Source link: https://ui.adsabs.harvard.edu/abs/2018PNAS..115.9473P/abstract


Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease

"Our unique combination of cellular biophysical markers strongly correlates with mean cellular volume rather than fetal hemoglobin level," providing insight into potential mechanisms by which HU treatment results in positive clinical outcomes. ".

Source link: https://ui.adsabs.harvard.edu/abs/2016PNAS..113.9527H/abstract


Density-based separation in multiphase systems provides a simple method to identify sickle cell disease

"Red blood cells with a high density are characteristic of sickle cell disease. " "This paper outlines a density-based separation of red blood cells in a reaqueous multiphase polymers that allows a visual examination of sickle cell disease originating from whole blood samples in less than 12 minutes. ".

Source link: https://ui.adsabs.harvard.edu/abs/2014PNAS..11114864K/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions