Scala - PubMed

Virally Mediated Connexin 26 Expression in Postnatal Scala Media Significantly and Transiently Preserves Hearing in Connexin 30 Null Mice.

The cochlea's sensory epithelium is tightly linked by gap junctions, with non-sensory cells being closely linked by gap junctions. Humans with hearing loss as a result of functionally null mutations in GJB6. We introduced AAV1-CB7-Gjb2 into the scala media between P0-2 and P0-2 in the Gjb6 cochlea (cochlea) of mice in this research. Our findings revealed the first successful cochlear gene therapy treatment in mouse models by virally expressing a companion gene for Gjb6.

Source link: https://doi.org/10.3389/fcell.2022.900416

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