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Non-sensory cells in the cochlea's sensory epithelium are strongly linked by gap junctions. Humans are the cause of hearing loss in humans due to genetically null mutations in GJB6. During the 3-month cycle, we discovered that the expression of Cx26, both the mRNA and protein levels, had substantial decreases. Our results revealed the first successful cochlear gene therapy treatment in mouse models by virally expressing a companion gene for Gjb6.
Source link: https://doi.org/10.3389/fcell.2022.900416
This review looked at the number of channels that could be used for maximum speech comprehension and sound quality in 15 adult cochlear implant recipients with Advanced Bionics Mid-Scala electrode arrays that were entirely within scala tympani. In experiment I, the CI programs used a continuous interleaved sampling -based approach and 4U201316 active electrodes. In experiment II, CI services employed an n-of-m approach that included 16 active electrodes in either 8- or 12-maxima, according to the authors. Both speech comprehension and sound quality control measures were evaluated. Participants in CIS programs reported success for their CIS services by using up to 4u201310 electrodes on speech measurements and sound quality ratings. There was no significant effect of maxima on this sample's maximum results and sound quality, according to an 8-maxima model. Lang, a British language. These results show that Mid-Scala electrode array recipients have demonstrated similar channel independence to straight electrode arrays rather than other manufacturer's precurved electrode arrays.
Source link: https://doi.org/10.1121/10.0012163
In cases of blocked scala tympani, we investigated the results of scala vestibuli insertion for cochlear implantation. Scala vestibuli insertion was successful in four cases of blockage of the scala tympani in a string of 200 cochlear implantations. The operative findings were similar to those in patients undergoing conventional scala tympani insertion was done. Scala vestibuli insertion provides a viable alternative in cases of obstructed scala tympani that can be used for a variety of etiologies.
Source link: https://doi.org/10.1159/000027755
We used an automated robot connected to a navigation device to align the pre-curved tip of the electrode array with the coiling direction of the scala tympani based on the tympani's intracochlear injury created by the HiFocus' U2122 Mid-Scala electrode array. In the first group, the robot was teleoperated to insert the electrode array into the ST's basal turn under stereomicroscopic inspection, and then the array was pushed by a slow-speed hydraulic insertion technique with estimated placement of the pre-curved electrode tip. The electrode array was manually adjusted after this, they supplied the instructions to the automated system to automatically align the electrode array with the ST insertion axis and to target the pre-curved tip toward the ST's subsequent coiling.
Source link: https://doi.org/10.1159/000517398
Methods: A set of ten adult human temporal bones was subjected to high-resolution CT scanning and then dissected for microscopic examination of the round window niche. The percentage of the area occupied by the crista fenestra in the whole circumference of the round window ranged from 23 to 50%. We found a moderate positive correlation between the region of the niche and the crista fenestra's dimensions. In each case, high-resolution CT scans were unable to detect the presence of the crista fenestra. Conclusion: The crista fenestra occupies a dynamic yet expressive region within the bony round window niche. However, a high-resolution CT scan does not provide any additional preoperative data with respect to its presence in the scala tympani's quest for surgical access through the round window niche.
Source link: https://doi.org/10.1159/000471840
We retrospectively compared the HiFocus MS electrode array's angular insertion depth and speech perception results after implantation and speech perception results, as well as the HiFocus 1J lateral wall electrode array. At 470,0b0, the mean angular insertion depth within the MS population was determined at 470. Audiological tests within a subgroup including only postlingual, unilaterally implanted, adult cochlear implant recipients who were matched on preoperative speech perception scores and duration of deafness showed no difference in language perception results between the MS and 1J groups, according to the MS and 1J groups.
Source link: https://doi.org/10.1159/000448581
In previous studies, round window membrane application of gentamicin created a dramatic peak concentration gradient in the perceptive turn of ST. Gentamicin sulfate, with peak concentrations in the basal turn of ST. Gentamicin sulfate in the bloodstream of perspirate in the percutaneous course of a 300 mg/kg body weight over a period of 3 h or as a 300 mg/kg body weight in the amount of 100, ST was obtained from the right and left cochlea's right and left cochlea's apex, respectively, by the beginning of the application, and ten sequential 1-u00b5l permex samples from each cochlea's apex were quantitatively measured using a fluorescence polarization immunoassay. In contrast to local RWM delivery, systemic application of gentamicin resulted in the highest perilmonia in the apex of the cochlea, with decreasing concentrations in the basal regions of ST.
Source link: https://doi.org/10.1159/000355283
Scala communis or interscalar septum defect is a developmental abnormality of the inner ear characterized by a dehiscence in the partition separating the cochlea's turns. Methods: Out of 1775 temporal bones, 22 specimens were discovered to have scala communis in cochleae containing all three turns. Scala communis was characterized as unusual inner ear anomaly or in conjunction with other congenital cochlear and/or vestibular abnormalities. Compared to control ears, scala communis ears were found to have less modiolar area and flattening of the interscalar ridge. Normal hearing was matched by Scala communis. Conclusions: Flattening of the interscalar ridge has the ability to aid in the diagnosis of scala communis in patients using CT scanning.
Source link: https://doi.org/10.1159/000307345
The injection of 4-aminopyridine into scala media of the guinea pig cochlea, increased of the thresholds of the compound action potential of the auditory nerve, loss of amplitude of the extracellular cochlear microphonic response, rise in the endocochlear microphonic response, increase in the endocochlear microphonic response, and decrease in the amplitude of electrically evoked oto-a.
Source link: https://doi.org/10.1159/000013776
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