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Last Updated: 20 May 2022

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Chasing the storm: Recruiting non-hospitalized patients for a multi-site randomized controlled trial in the United States during the COVID-19 pandemic.

A research into prospective participants who are sick with COVID-19 can be frightening, overwhelmed, or mistrusting clinical evidence is a challenge. Rapid expansion of sites, modification of recruitment scripts, evaluating phone calls versus text messages for initial contact with participants, institutional review board-approved financial compensation, and large-scale media campaigns with varying degrees of success were among ColCorona's efforts to improve United States recruitment.

Source link: https://doi.org/10.1111/cts.13211


Brain site-specific regulation of hedonic intake by orexin and DYN peptides: role of the PVN and obesity.

Different brain locations display orexin peptides that promote hedonic intake and other reward behaviors. Obesity alters the expression of orexin and dynorphin receptor receptors, but it's unclear whether their expression across different brain regions is relevant to hedonic intake. We hypothesized that orexin and dynorphin peptides in PVN regulate hedonic intake, and that hedonic intake in obesity correlates with expression of their receptors. In mice, injection of DYN-A1-13 in the PVN increased hedonic intake, while in the VTA, injection of OXA increased hedonic intake. In PVN, injection of norBNI reduced hedonic intake, but a subsequent OXA injection failed to raise hedonic intake, reducing hedonic intake, indicating that OXA action in PVN is not influenced by endogenous opioid activity. Orexin 1 receptor mRNA across brain regions involved in hedonic intake correlated with fat preference but not caloric intake in obese mice fed a cafeteria diet.

Source link: https://doi.org/10.1080/1028415X.2020.1840049

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions