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Rifampin - Crossref

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Last Updated: 05 December 2022

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In vitro synergistic antimicrobial activity of a combination of meropenem, colistin, tigecycline, rifampin, and ceftolozane/tazobactam against carbapenem-resistant Acinetobacter baumannii

Abstract We investigated the in vitro activity of several antimicrobial combinations against carbapenem-resistant Acinetobacter baumannii isolates. The in vitro activity of six two-drug combinations against CRAB isolates isolated from blood samples of patients with bloodstream infection was determined using the checkerboard method and a minimum inhibitory concentration [0. 5 u00d7, 1 u00d7, 1 u00d7, and 2 u00d7 minimum inhibitory concentration] to discover potential synergistic and bactericidal two-drug mixtures against CRAB isolates isolated from blood samples of patients with bloodstream infection The OXA-58-type and OXA-23-type carbapenem-hydrolyzing oxacillinases were isolated from all 10 CRAB isolates in our research, resulting in the OXA-58-type and OXA-23-type carbapenem-hydrolyzing oxacillinases. Our analysis showed that two-drug mixtures of colistin and ceftolozane/tazobactam could be viable treatment options for CRAB infections.

Source link: https://doi.org/10.1038/s41598-022-11464-6


Efficiency of Rifampin-loaded chitosan NPs in Killing of Brucella melitensis Isolated From Aborted Sheep in Wasit Province, Iraq

Brucellosis is recognized as one of the utmost common bacterial infectious disease that affects both man and animals. Hence, the aim of this research is the synthesis of chitosan nanoparticles loaded with rifampin to combat bacterial resistance and increase intracellular penetration, as well as the potential for potent intracellular antibacterial activity. The RIF-CHNPs particle size measured using SEM images was 260. 54 nm, while the diameter was 150. 23 nm. At a concentration of 50 mg/ml, Loaded antibiotic formulation demonstrated a high degree of entrapment stability and drug loading. The EE % at concentration 50 mg/ml was re-estimated in different pH conditions, and the highest EE% was pH 5. In conclusion, the antibacterial activity of drug nanocarrier against B. melitensis was found to have a relatively low MIC of 0. 625 ug/ml. Comparing to the MIC of antibiotic alone, Indicating that there was 6. 4 times decrease in MIC for RIF-CHTNPs and 1. 6 time reduction for CHTNPs.

Source link: https://doi.org/10.47750/pnr.2022.13.04.082


Risk factors for side-effects of isoniazid, rifampin and pyrazinamide in patients hospitalized for pulmonary tuberculosis

Patients hospitalized as a result of pulmonary tuberculosis were randomized to determine the current incidence of side-effects severe enough to cause intolerance of standard antituberculosis therapy with isoniazid, rifampin, and pyrazinamide. Patients with established pulmonary tuberculosis, who were first treated with standard antituberculosis treatment, were retrospectively examined in a teaching chest hospital's department of infectious diseases. Pyrazinamide had more severe side-effects than isoniazid and rifampin, with more severe side-effects than isoniazid and rifampin. Both of these risk factors were also closely linked to pyrazinamide's intolerance, but not of isoniazid and rifampin. Patients with hospitalized patients aged > or = 60 years or with a history of previous hepatitis are likely due to pyrazinamide rather than isoniazid or rifampin.

Source link: https://doi.org/10.1183/09031936.96.09102026


Treatment of a Mycotic Descending Thoracic Aortic Aneurysm Using Endovascular Stent-Graft Placement and Rifampin Infusion With Postoperative Aspiration of the Aneurysm Sac

Purpose: Mycotic aortic aneurysms are unusual, but they are associated with high morbidity and mortality due to their propensity for rupture. Case description: An 85-year-old male with persistent bacteremia was found to have a descending mycotic aneurysm. Conclusion: The perioperative mortality and long-term risk of infection associated with mycotic thoracic aneurysms can potentially be reduced by combining traditional surgical methods with a modern endovascular strategy.

Source link: https://doi.org/10.1177/1538574411418007


The effect of rifampin on the pharmacokinetics of famitinib in healthy subjects

The trial was conducted to see the effect of potent CYP3A4 inducer rifampin on famitinb's pharmacokinetics as famitinib is metabolized predominantly by cytochrome P450 3A4 P450 3A4 rifampin kinetics. On days 1 and 16, subjects received a single oral dose of famitinib 25 mg, as well as repeating oral rifampin 600 mg once daily on days 10 to 201323. Both subjects experienced treatment emergent adverse events, and five out of eight subjects reported treatment emergent adverse effects, which were all grade 1 to 20132 in severity. Conclusion Coordination of rifampin drastically reduces plasma famitinb concentrations in CYP3A4 induction due to its CYP3A4 induction. When simultaneous use of CYP3A4 inducers is used, concomitant administration of famitinib and strong CYP3A4 inducers should be avoided, although when simultaneous use of inducers of CYP3A4 is encouraged, dose adjustment of famitinb is recommended.

Source link: https://doi.org/10.1007/s00280-022-04474-8


Hepatoprotective Activity of Pongamia Pinnata Leaves on Antitubercular Drugs (Isoniazid & Rifampin) Induced Hepatotoxicity in Rats

Rats were killed by the hemotoxic effect of an ethanolic extract of Pongamia Pinnata on antitubercular drugs, which caused hepatotoxicity in rats. The experiment used five species of male wistar rats, each with six individuals. Pongamia Pinnata ethanolic extract was found to be lower than when rats were given a mixture of antitubercular drugs and a high percentage of an ethanolic extract of Pongamia Pinnata alone, which was lower than when rats were given antitubercular medications alone. Pongamia Pinnata extract with antitubercular drugs decreased MDA levels and elevated thiol levels in a significant manner.

Source link: https://doi.org/10.9734/jpri/2021/v33i62a35555


Hepatoprotective Effect of Annona Squamosa Linn. (AS) Leaves on Isoniazid & Rifampin Induced Hepatotoxicity in Rats

This research was conducted to see if an ethanolic extract of Annona squamosa has any hepatoprotective properties in rats suffering from isoniazid-rifampin-induced hepatotoxicity. Methodology: The rats were divided into five groups: group 1, a control; group 2 administered isoniazid & rifampin in sterile water; group 3 as a monitor; traditional silymarin, 2. 5 mg/kg, B. W. , P. O. Rats treated with Rifampin & Isoniazid elevated their blood Serum Glutamic Oxymorgation (Serum Glutamate Phosphatase), Serum Glutamate pyruvic transaminase & Alkaline Phosphatase levels in a variety of ways. The consumption of ethanolic extracts of Annona squamosa has significantly reduced Rifampin & Isoniazid-induced serum diagnostic liver marker enzyme levels. Rats are immune to oxidative liver damage caused by rifampin & isoniazid, thanks to an ethanolic extract of Annona squamosa. Conclusion: The ethanolic extract of AS keeps rats safe from isoniazid and rifampin-induced oxidative liver injury.

Source link: https://doi.org/10.9734/jpri/2021/v33i62b35181


Determination of the prevalence of antimicrobial resistance to macrolide antimicrobials or rifampin in Rhodococcus equi isolates and treatment outcome in foals infected with antimicrobial-resistant isolates of R equi

Abstract aims: u2014 Objective : u2014 To determine the prevalence of antimicrobial resistance in Rhodococcus equi isolates and to report treatment outcomes in foals infected with antimicrobial-resistant isolates of R equi. Sample population u201438 isolates from 9 veterinary diagnostic laboratories between January 1997 and December 2008 were found to be resistant to macrolide antimicrobials or rifampin. Ifampin was determined, there were R equi isolates from Florida and Texas that were resistant to macrolide antimicrobials or rifampin. Outcome of antimicrobial therapy in foals infected with antimicrobial-resistant isolates of R equi was established. The survival rate of foals infected with resistant R equi isolates was significantly lower than that of foals treated with the same antimicrobial therapy in which antimicrobial-susceptible isolates were cultured, compared to the survival percentage in foals with the same antimicrobial-susceptible isolates were cultured. Odds of nonsurvival for foals infected with non-resistant R equi isolates were 6. 9 times higher than those with susceptible isolates in foals infected with resistant R equi isolates, which was 6. 9 times greater than those with susceptible R equi isolates.

Source link: https://doi.org/10.2460/javma.237.1.74


Combination of Isoniazid and Rifampin for the Prevention of Failure of Standard Therapy for Latent Tuberculosis Infection in Children: Evidence Base Case Report

Three methods are employed in children's Tuberculosis control: finding and diagnosing adult TB infections, treating latent TB infections, and administering the BCG vaccine. The body's resistance to Mycobacterium tuberculosis occurs after Mycobacterium is inhaled through the respiratory tract. In addition, there are two possibilities: only TB infection is present, or the child has TB disease. Adult TB patients have a history of interacting with adult TB patients. Prophylaxis with Isoniazid was scheduled for six months after the diagnosis of latent TB infection. According to the rules, the child still needs to take medications in the first month. However, children often do not want to take medication while in the second month. This therapeutic decision was based on a study that found that mixing INH and rifampin for three months produced higher results than single prophylactic therapy with INH.

Source link: https://doi.org/10.21157/ijtvbr.v6i1.23040

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions